Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Jeffrey W. Clark"'
Autor:
Yves Boucher, Jessica M. Posada, Sonu Subudhi, Spencer R. Rosario, Liqun Gu, Ashwin S. Kumar, Heena Kumra, Mari Mino-Kenudson, Nilesh P. Talele, Dan G. Duda, Dai Fukumura, Jennifer Y. Wo, Jeffrey W. Clark, David P. Ryan, Carlos Fernandez-Del Castillo, Theodore S. Hong, Mikael J. Pittet, Rakesh K. Jain
Publikováno v:
Cancer Research. 82:C043-C043
Purpose: Adding losartan to FOLFIRINOX (FFX) chemotherapy followed by chemoradiation (CRT) resulted in 61% R0 surgical resection in our phase II trial in patients with locally advanced pancreatic cancer. Here we identify potential mechanisms of benef
Autor:
Carlos Fernandez-del Castillo, Yves Boucher, Dai Fukumura, Nilesh Talele, David P. Ryan, Jessica M. Posada, Rakesh K. Jain, Ivy X. Chen, Jeffrey W. Clark, Mei Rosa Ng, Mari Mino-Kenudson, Sonu Subudhi, Janet E. Murphy, Ashwin S. Kumar, Theodore S. Hong, Dan G. Duda
Publikováno v:
Cancer Research. 81:PO-097
Purpose: A phase II trial in patients with locally-advanced pancreatic cancer (LAPC) revealed unprecedented rates of complete surgical resection after adding losartan (L) to FOLFIRINOX (FFX) chemotherapy followed by chemoradiation (CRT) (NCT01821729)
Autor:
Michael Downes, Yves Boucher, Kamila Naxerova, Ronald M. Evans, Daniel H. Schanne, Jonathan Crain, Cristina R. Ferrone, Rakesh K. Jain, Xialong Qi, Carlos Fernandez-del Castillo, William Ho, Keith D. Lillemoe, Jeffrey W. Clark, David P. Ryan, Jelena Grahovac, Ivy X. Chen, Matthias Pinter, Hadi Tavakoli Nia, Theodore S. Hong, Jessica M. Posada, Hao Liu, Peigen Huang, Vikram Deshpande
Publikováno v:
Cancer Research. 79:A18-A18
The resistance to therapy in pancreatic ductal adenocarcinoma (PDAC) is due in part to carcinoma-associated fibroblasts (CAFs) that produce a highly desmoplastic and proinflammatory tumor microenvironment (TME). Our laboratory has shown that the angi
Autor:
Aparna R. Parikh, Ignaty Leshchiner, Liudmila Elagina, Lipika Goyal, Chaya Levovitz, Giulia Siravegna, Dimitri Livitz, Kahn Rhrissorrakrai, Liz Martin, Emily E. Van Seventer, Megan Hanna, Kara Slowik, Filippo Utro, Christopher J. Pinto, Alicia Wong, Brian P. Danysh, Ferran Fece de la Cruz, Isobel J. Fetter, Brandon Nadres, Heather A. Shahzade, Jill N. Allen, Lawrence S. Blaszkowsky, Jeffrey W. Clark, Bruce Giantonio, Janet E. Murphy, Ryan D. Nipp, Eric Roeland, David P. Ryan, Colin D. Weekes, Eunice L. Kwak, Jason E. Faris, Francois Aguet, Ipsita Guha, Mehlika Hazar-Rethinam, Dora Dias-Santagata, David T. Ting, Andrew X. Zhu, Theodore S. Hong, Todd R. Golub, A J. Iafrate, Viktor Adalsteinsson, Alberto Bardelli, Laxmi Parida, Dejan Juric, Gad Getz, Ryan B. Corcoran
Publikováno v:
Cancer Research. 79:LB-257
The inevitable emergence of acquired resistance is a major limitation to the clinical benefit of precision medicine strategies. Single-lesion tumor biopsies have long been the mainstay of understanding acquired resistance, but recent data suggest tum
Autor:
Paul C. Shellito, Jeffrey W. Clark, Marek Ancukiewicz, Emmanuelle di Tomaso, Pei-Chun Lin, Gregory Y. Lauwers, Lei Xu, Dan G. Duda, Daniel C. Chung, Rekha Samuel, Martin Poleski, Brian G. Czito, Christopher G. Willett, Rex C. Bentley, Rakesh K. Jain
Publikováno v:
Cancer Research. 69:7905-7910
Clinical studies converge on the observation that circulating cytokines are elevated in most cancer patients by anti–vascular endothelial growth factor (VEGF) therapy. However, the source of these molecules and their relevance in tumor escape remai
Autor:
Dmitriy Kedrin, William T. Ho, Keehoon Jung, Juergen Weitz, Christina M. Edrich, Yves Boucher, Dan G. Duda, Ivy X. Chen, Christoph Reissfelder, Alan J. Grodzinsky, Jeffrey W. Clark, Julien Daubriac, Joao Incio, Rakesh K. Jain, Takahiro Heishi, Dai Fukumura, Nuh N. Rahbari, Nir Maimon, Yuhui Huang, John D. Martin, Hadi Tavakoli Nia, Hao Liu
Publikováno v:
Cancer Research. 77:PR06-PR06
Introduction: The anti-VEGF antibody bevacizumab in combination with chemotherapy is a standard treatment for metastatic colorectal cancer (mCRC) today, based on an overall survival improvement. However, this survival benefit is modest and mCRC ultim
Autor:
Daniel A. Haber, Matteo Ligorio, Kristina Xega, Laura Indolfi, Robert Langer, Nicola Aceto, Francesca Bersani, Jeffrey W. Clark, Cristina R. Ferrone, Elazer R. Edelman, David T. Ting
Publikováno v:
Cancer Research. 74:4584-4584
INTRODUCTION. The majority of patients with pancreatic ductal adenocarcinoma (PDAC) succumb to the disease within 12-24 months from their diagnosis mainly due to the intrinsic chemorefractory behavior of this cancer. Chemoresistance is a multifactori
Autor:
M. Campone, F. Abdulsater, J-L Canon, P. Hilbert, J-P. Machiels, S. Toffoli, Jeffrey W. Clark, Isabelle Bar, H. Roche, Javier Carrasco, A-L Martin, Paul Delrée, F Moreau, F Cavallin, Magali Lacroix-Triki
Publikováno v:
Cancer Research. 72:P3-04
Background: Triple Negative Breast Cancers (TNBC) represent 12% to 20% of total Breast Cancers (BC) and have a worse outcome compared with other breast cancer subtypes. TNBC often show a deficiency in DNA double strand break repair mechanisms. This d
Autor:
Sara M. Tolaney, Sheelagh Frame, John Hilton, David Blake, Judy H. Chiao, James M. Cleary, John T. Schulz, Eunice L. Kwak, Morag Hogben, Chiara Saladino, Tracy Bell, Andrew Wolanski, Jeffrey W. Clark, Leena Ghandi, Geoffrey I. Shapiro, Scott J. Rodig
Publikováno v:
Cancer Research. 73:LB-202
Background: Sapacitabine is an orally administered nucleoside analogue; the active metabolite, CNDAC (2′-C-cyano-2′-deoxy-1-β-D-arabino-pentofuranosylcytosine), generates single-strand DNA breaks that are converted to double-strand DNA breaks (D
Autor:
Jeffrey W. Clark, Keith D. Wilner, Bruce J. Dezube, Weiwei Tan, Dana J. Nickens, D. Ross Camidge, Geoffrey I. Shapiro
Publikováno v:
Cancer Research. 70:1673-1673
Objective: Assess the potential effect of PF-1066 plasma concentrations on the observed RR corrected QT interval in patients with advanced cancer. Methods: Plasma concentrations of PF-1066 (total drug) and ECG data were collected in study A8081001, a