Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Ichinosuke Hyodo"'
Publikováno v:
Cancer Research. 79:4839-4839
Introduction and Aim: Inactivation of the TP53 tumor suppressor gene is important for cancer development and progression. Wild-type (wt) TP53 is inactivated in various types of cancers including colon and gastric cancers by upregulated murine double
Autor:
Taro Yamashita, Ichinosuke Hyodo, Ryoko Shirota, Yukio Nakamura, Inaho Danjoh, Shinji Endo, Masato Abei, Takeshi Yamada
Publikováno v:
Cancer Research. 75:1397-1397
Background: Recent cancer stem cell (CSC) research has highlighted the necessity to develop drugs targeting CSCs. However, only few in vitro models are available which show CSC hierarchy and allow monitoring of CSC differentiation and screening of dr
Autor:
Yoshiyuki Yamamoto, Masahiro Yasunaga, Yasuki Kato, Ryo Tsumura, Toshihumi Obonai, Yasuhiro Matsumura, Hirobumi Fuchigami, Ryuta Sato, Yoshikatsu Koga, Mitsunori Harada, Ichinosuke Hyodo, Tatsuyuki Hayashi, Masahisa Kudo
Publikováno v:
Cancer Research. 74:2648-2648
Background: Anticancer agent-incorporating polymeric micelles, categorized as passive targeting agents, are expected to accumulate in tumors based on the enhanced permeability and retention effect. Recently, we made epirubicin-incorporating micelles
Autor:
Mitsuaki Hirose, Rie Saito, Ichinosuke Hyodo, Kenji Yamato, Sachiko Hirai, Takunori Ueno, Hideo Suzuki, Shinji Endo
Publikováno v:
Cancer Research. 74:2603-2603
Background: Murine double minute 2 (MDM2) is an oncoprotein that inactivates p53 tumor suppressor protein by ubiquitination and subsequent proteasomal degradation. MDM2 is overexpressed in 10%-20% of human cancers, most of which carry wild-type (wt)
Autor:
Masahiro Yasunaga, Yoshiyuki Yamamoto, Misato Takigahira, Ichinosuke Hyodo, Yasuhiro Matsumura, Tatsuyuki Hayashi, Yoshikatsu Koga, Yasuki Kato, Mitsunori Harada
Publikováno v:
Cancer Research. 73:4525-4525
Background: Several anticancer agent (ACA)-incorporating polymeric micelles are known to accumulate effectively in tumors and exert sufficient antitumor effects via the enhanced permeability and retention (EPR) effect. These agents are now under clin
Autor:
Takunori Ueno, Kenji Yamato, Shinji Endo, Mitsuaki Hirose, Ichinosuke Hyodo, Sachiko Hirai, Hideo Suzuki
Publikováno v:
Cancer Research. 72:4716-4716
Aim: Tenovin-6 is one of the small molecule inhibitors of Histone Deacetylase (HDAC), which have been to shown to suppress cancer cell growth and angiogenesis. In Japan, the mortality of gastric cancer is still high and innovative strategies are requ
Autor:
Yasuki Kato, Mitsunori Harada, Tatsuyuki Hayashi, Ichinosuke Hyodo, Masahiro Yasunaga, Ryosuke Tanaka, Hiroyuki Saito, Yoshiyuki Yamamoto, Yoshikatsu Koga, Yasuhiro Matsumura, Amane Takahashi
Publikováno v:
Cancer Research. 72:LB-11
Background: Epirubicin, an anthracycline antitumor drug, has been approved for the treatment of various human tumors. However, epirubicin has significant dose-limiting cardiotoxicity, and there are no effective therapies to prevent or reduce this car
Publikováno v:
Cancer Research. 70:4530-4530
Purpose: The mortality of gastric cancer is still high accounting for an estimated 50,000 deaths in Japan. The chemotherapies based on fluoropyrimidine and platinum complexes are widely used for unresectable advanced gastric cancer, however, developm