Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Herbert J. Zeh"'
Autor:
Herbert J. Zeh, Farzad Esni, Zobeida Cruz-Monserrate, Jing Hu, Michael T. Lotze, Mairobys Socorro, George K. Gittes, Vincent Goffin, Gina M. Coudriet, Aatur D. Singhi, Mouhanned Eliliwi, Andrew V. Biankin, Peter Bailey, Angela Criscimanna, Manuj Tandon
Publikováno v:
Cancer Research. 79:5316-5327
Pancreatic ductal adenocarcinoma (PDAC) is associated with significant fibrosis. Recent findings have highlighted the profibrotic activity of tissue-resident macrophages in the pancreatic cancer microenvironment. Here, we show that neoplastic pancrea
Autor:
Qiuhong Zhang, Shan Zhu, Michael T. Lotze, Xiaofang Sun, Rui Kang, Daolin Tang, Herbert J. Zeh
Publikováno v:
Cancer Research. 77:2064-2077
Ferroptosis is a form of regulated cell death driven by oxidative injury promoting lipid peroxidation, although detailed molecular regulators are largely unknown. Here, we show that heatshock 70-kDa protein 5 (HSPA5) negatively regulates ferroptosis
Autor:
Ravikumar Muthuswamy, Erik Berk, Beth Fallert Junecko, Herbert J. Zeh, Amer H. Zureikat, Daniel Normolle, The Minh Luong, Todd A. Reinhart, David L. Bartlett, Pawel Kalinski
Publikováno v:
Cancer Research. 72:3735-3743
Tumor infiltration with effector CD8+ T cells (Teff) predicts longer recurrence-free survival in many types of human cancer, illustrating the broad significance of Teff for effective immunosurveillance. Colorectal tumors with reduced accumulation of
Inhibiting Systemic Autophagy during Interleukin 2 Immunotherapy Promotes Long-term Tumor Regression
Autor:
William Buchser, Antonio Romo de Vivar Chavez, Bennett Van Houten, Patricia Loughran, Tao Wang, Per H. Basse, Xiaoyan Liang, Michael E. de Vera, Herbert J. Zeh, Donna B. Stolz, Michael T. Lotze
Publikováno v:
Cancer Research. 72:2791-2801
Administration of high-dose interleukin-2 (HDIL-2) has durable antitumor effects in 5% to 10% of patients with melanoma and renal cell carcinoma. However, treatment is often limited by side effects, including reversible, multiorgan dysfunction charac
Autor:
Kristen M. Livesey, Simon C. Watkins, Michael T. Lotze, James J. Manfredi, Herbert J. Zeh, Rui Kang, Patricia Loughran, Philip Vernon, William Buchser, Lin Zhang, Daolin Tang, Lu-Yuan Li
Publikováno v:
Cancer Research. 72:1996-2005
The balance between apoptosis (“programmed cell death”) and autophagy (“programmed cell survival”) is important in tumor development and response to therapy. Here, we show that high mobility group box 1 (HMGB1) and p53 form a complex that reg
Autor:
Ben Staal, Ying Huang, Brian B. Haab, Herbert J. Zeh, Ying Liu, Randall E. Brand, Richard R. Drake, Katie Partyka, Daniel Barnett, Aatur D. Singhi
Publikováno v:
Cancer Research. 78:4624-4624
The CA19-9 biomarker is elevated in a substantial group of patients with pancreatic cancer, but not enough to be reliable for detection, diagnosis, or monitoring of the disease. We hypothesized that a glycan called sTRA complements CA19-9, and that t
Autor:
Bernard Moss, David L. Bartlett, Xiaoyu Yin, Shuting Yang, Richard A. DeMarco, Yun Hu, Michael T. Lotze, Petar J. Popovic, Mark E. O'Malley, Arpana Naik, Herbert J. Zeh, Z. Sheng Guo
Publikováno v:
Cancer Research. 65:9991-9998
The ability of cancer cells to evade apoptosis may permit survival of a recombinant vaccinia lacking antiapoptotic genes in cancer cells compared with normal cells. We have explored the deletion of two vaccinia virus host range/antiapoptosis genes, S
Autor:
Brian B. Haab, Galen Hostetter, Herbert J. Zeh, Ying Liu, Daniel H. Barnett, Randall E. Brand, Aatur D. Singhi, Katie Partyka, Richard R. Drake, Ying Huang
Publikováno v:
Cancer Research. 77:1754-1754
A major challenge in diagnosing and treating pancreatic cancer is the complex diversity between and within tumors in cellular morphologies and behaviors. Molecular markers to detect and classify specific variants of cancer cells could facilitate drug
Publikováno v:
Cancer Research. 76:3009-3009
Introduction: Pseudomyxoma peritonei (PMP) is an indolent malignancy characterized by excessive production of Mucin 2 (MUC2; a gel-forming secreted mucin). We have previously demonstrated mucinous tumor growth inhibition in a patient-derived murine x
Autor:
Herbert J. Zeh, David L. Bartlett, Haroon A. Choudry, Zong Sheng Guo, Arun Mavanur, Mark E. O'Malley
Publikováno v:
Cancer Research. 72:5253-5253
Introduction: Pseudomyxoma peritonei (PMP) is characterized by compressive organ dysfunction from progressive intra-peritoneal accumulation of mucinous ascites. MUC2 is the primary secreted mucin in PMP and the MAPK signaling pathway is involved in M