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pro vyhledávání: '"Francisco D. Morón-Duran"'
Autor:
Albert Tauler, Sara C. Kozma, George Thomas, Francisco D. Morón-Duran, Carmen Morcelle, Antonio Gentilella, Sandra Menoyo
Publikováno v:
Cancer research. 79(17)
The role of MYC in regulating p53 stability as a function of increased ribosome biogenesis is controversial. On the one hand, it was suggested that MYC drives the overexpression of ribosomal proteins (RP)L5 and RPL11, which bind and inhibit HDM2, sta
Autor:
Guilherme Z. Rocha, George Thomas, Ferran Riaño-Canalias, Joffrey Pelletier, Francisco D. Morón-Duran, Sara C. Kozma, Antonio Gentilella, Albert Tauler
Publikováno v:
Cancer Research. 77:PR02-PR02
The ability of ribosomes to translate genetic information into protein is a hallmark of evolution. However, during cancer progression, tumors often hijack and boost ribosome biogenesis in their favor, which they rely on for high rates of proliferatio