Zobrazeno 1 - 10
of 16
pro vyhledávání: '"David W. Lee"'
Autor:
Marvin O'Ketch, Jeffrey A. Kiefer, Dnyanesh Rasale, Warren S. Weiner, Lizette A. Castaño, Nathalie A. Azorsa, David W. Lee, Kerry M. Barnhart, Spyro Mousses, David O. Azorsa
Publikováno v:
Cancer Research. 83:4417-4417
T-cells in the tumor microenvironment can often become exhausted and dysfunctional due to chronic and prolonged exposure to antigen. The resulting condition of T cell exhaustion represents an important mechanism of clinical resistance to immune check
Autor:
David O. Azorsa, David W. Lee, Marvin O'Ketch, Nathalie A. Azorsa, Ioanna Papacharalampous, Lizette A. Castaño, Jeffrey A. Kiefer, Spyro Mousses
Publikováno v:
Cancer Research. 82:4096-4096
Ubiquitination is a metabolic process in eukaryotic cells that modifies proteins with ubiquitin leading to protein degradation via the ubiquitin-proteosome pathway. Cellular levels of ubiquitin are driven by the expression of RPS27A, UBA52, UBB and U
Autor:
Marvin O'ketch, Victoria A. Love, Jeffrey A. Kiefer, David W. Lee, Lizette A. Castaño, Spyro Mousses, David O. Azorsa
Publikováno v:
Cancer Research. 82:4239-4239
T-cell exhaustion describes the dysfunctional state of effector T cells in the tumor microenvironment that results from chronic and prolonged exposure to antigen. It also represents an important mechanism of clinical resistance to immune checkpoint b
Autor:
Justin J. Montoya, Megan A. Turnidge, Daniel H. Wai, David W. Lee, Apruvi Patel, Vijay Gokhale, Laurence J. Hurley, David O. Azorsa
Publikováno v:
Cancer Research. 79:2967-2967
Acute Myeloid Leukemia (AML) is a malignancy of myeloid precursor cells that can occur when genomic changes alter expression of key genes, causing cells to resume an undifferentiated state and proliferate. Ongoing efforts have focused on developing t
Autor:
Vijay Gokhale, Daniel H. Wai, David W. Lee, Laurence H. Hurley, Justin J. Montoya, David O. Azorsa, Robert J. Arceci, Apurvi Patel, Megan A. Turnidge
Publikováno v:
Cancer Research. 78:B04-B04
Acute myeloid leukemia (AML) is a disease that can affect both children and adults and is characterized by complex and heterogeneous genomic changes, including MYC overexpression driven in part by the bromodomain (BRD) and extraterminal (BET) protein
Publikováno v:
Cancer Research. 77:2349-2349
Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children and young adults. The five-year survival rate for RMS has hardly improved over the last three decades despite intensive and toxic chemotherapy, radiotherapy with surgery. There
Autor:
David W. Lee, Justin J. Montoya, Daniel H. Wai, David O. Azorsa, Robert J. Arceci, Apurvi Patel
Publikováno v:
Cancer Research. 77:4077-4077
Patients with Down’s syndrome who develop acute myeloid leukemia (AML) are at increased risk of toxicity secondary to chemotherapy regimens. These patients are harder to treat with conventional therapies at relapse. Overall, the use of targeted dru
Autor:
David O. Azorsa, Justin J. Montoya, Daniel H. Wai, Robert J. Arceci, David W. Lee, Oliver B. Pepper, Peter Azorsa
Publikováno v:
Cancer Research. 77:3338-3338
Ewing sarcoma is the second most common cancer of bone and soft tissue arising in children and young adults. Although the survival rate has improved for patients treated for localized disease, the survival rate for patients with metastatic tumor rema
Abstract 5181: Targeted knockdown of MYC in AML cells using G-quadruplex interacting small molecules
Autor:
Vijay Gokhale, Robert J. Arceci, Megan A. Turnidge, Laurence H. Hurley, David O. Azorsa, Justin J. Montoya, Daniel H. Wai, David W. Lee, Apurvi R. Patel
Publikováno v:
Cancer Research. 77:5181-5181
Acute Myeloid Leukemia (AML) is a disease that occurs when genomic changes alter expression of key genes, causing cells to resume an undifferentiated state, proliferate, and maintain tumor growth throughout the body. Recently, there has been an incre
Autor:
David O. Azorsa, Robert J. Arceci, Vijay Gokhale, Daniel H. Wai, Justin J. Montoya, Laurence H. Hurley, Apurvi Patel, David W. Lee, Megan Turnidge, Eiman Aleem
Publikováno v:
Cancer Research. 76:3766-3766
Cancer is a disease that can be characterized by overexpression of key oncogenic drivers that support tumor development and maintenance. In many instances, these oncogenic drivers are ‘undruggable’ because of structural challenges, the inability