Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Chris Merritt"'
Autor:
Xiao-Jun Ma, Chris Merritt, Karen Nguyen, Anushka Dikshit, Courtney Anderson, Jill McKay-Fleisch, Daniel R. Zollinger
Publikováno v:
Cancer Research. 80:2707-2707
The canonical WNT-β-catenin signaling pathway is vital for development and tissue homeostasis but becomes strongly tumorigenic when dysregulated. This pathway can alter the transcriptional signature of a cell to promote malignant transformation, gro
Autor:
Daniel R. Zollinger, Chris Merritt, Joseph M. Beechem, Kristina Sorg, Oliver Appelbe, Damian Cockfield, Danielle Aaker, Sarah Ketting
Publikováno v:
Cancer Research. 80:5237-5237
Characterization of the spatial distribution and abundance of proteins and mRNAs with morphological context within tissues enables a better understanding of biological systems in many research areas, including immunology and oncology. The GeoMxTM Dig
Autor:
Chris Merritt, Joseph M. Beechem, Michelle Kriner, Erin Piazza, Zach Norgaard, Zoey Zhou, Michael Rhodes, Marty Ross, Nileshi Saraf, Margaret L. Hoang, Patrick Danaher, Robin Fropf, Kristina Sorg
Publikováno v:
Cancer Research. 80:1364-1364
The emerging field of spatial genomics represents a significant advance for biology. To drive new discoveries in spatial genomics and immuno-oncology, we introduce the GeoMx Cancer Transcriptome Atlas (CTA) Panel for comprehensive spatial analysis of
Autor:
Erin Piazza, Dae Kim, Kristina Sorg, Michelle Kriner, Margaret L. Hoang, Zach Norgaard, Zoey Zhou, Chris Merritt, Joseph M. Beechem
Publikováno v:
Cancer Research. 79:753-753
Clinical specimens including formalin-fixed, paraffin embedded (FFPE) tumor sections preserve spatial and molecular information of tumor cells and their surrounding microenvironment. This valuable spatial information is loss with bulk RNA-seq, the mo
Autor:
Joseph M. Beechem, Elena Viboch, Giang T. Ong, Gokhan Demirkan, Chris Merritt, Dwayne Dunaway, Kristina Sorg, Kristi Zevin, Gary K. Geiss, Lindy Irving
Publikováno v:
Cancer Research. 79:146-146
Characterization of the spatial distribution and abundance of proteins and mRNAs with morphological context within tissues enables a better understanding of biological systems in many research areas, including immunology and oncology. However, it has
Autor:
Heather Metz, Alison VanSchoiack, Quoc Huynh, Sarah H. Warren, Kristi Barker, Lucas Dennis, Jingjing Gong, Beechem Joseph M, Chris Merritt, Yan Liang
Publikováno v:
Cancer Research. 78:3858-3858
Mouse models of cancer are an invaluable biomedical research tool in which characterization of the abundance, distribution and co-localization of immuno-oncology targets is critical for the advancement of disease understanding. Nanostring Technologie
Autor:
Joseph M. Beechem, Harriet M. Kluger, David L. Rimm, Chris Merritt, Sarah Warren, Pok Fai Wong, Giang T. Ong, Yuting Liu, Maria I. Toki
Publikováno v:
Cancer Research. 78:3621-3621
Background: Quantitative immunofluorescence (QIF) offers the advantage of multiple target measurement on a single slide, but is limited by the number of fluorescence channels. NanoString's Digital Spatial Profiling (DSP)* can detect and quantify immu
Publikováno v:
Cancer Research. 78:2342-2342
Cell line screening studies require highly efficient protocols for studying many samples in parallel. We have developed a lyse-and-go protocol for digital gene expression profiling of 96-samples by 96-genes in parallel. This protocol is based on nCou
Autor:
Kristina Sorg, Daniel R. Zollinger, Jill McKay-Fleisch, Joseph M. Beechem, Karen Nguyen, Kristi Barker, Chris Merritt
Publikováno v:
Cancer Research. 78:3434-3434
Characterization of spatial mRNA expression across multiple targets in a single tissue section has proven difficult to accomplish. To address this unmet need, we have developed a novel imaging platform, Digital Spatial Profiling (DSP), designed to si
Autor:
Sarah Warren, Giang T. Ong, Yan Liang, Fiona Pakiam, Jaemyeong Jung, Dwayne Dunaway, Chris Merritt, Gordon B. Mills, Joseph M. Beechem, Isaac Sprague
Publikováno v:
Cancer Research. 77:3955-3955
Introduction: As intra-tumoral heterogeneity has emerged as a challenge in development of targeted cancer therapeutics, the tissue context of biomarker levels and colocalization of key immunoregulatory proteins has become an increasingly important as