Zobrazeno 1 - 10
of 56
pro vyhledávání: '"642"'
Autor:
Chi Ma, Justin McCallen, John C. McVey, Qianfei Zhang, Benjamin Ruf, Kylynda Bauer, Sophie Wang, Chunwei Walter Lai, Giorgio Trinchieri, Jay A. Berzofsky, Firouzeh Korangy, Tim F. Greten
Publikováno v:
Cancer Research. 83:642-642
The gut microbiome is an important modulator of the host immune system. Here, we found that altering the gut microbiome by oral vancomycin increases liver NKT cell function. Enhanced NKT cytokine production and activation marker expression were obser
Autor:
Hongming Xu, Yoon Jin Cha, Jean Clemenceau, Jinhwan Choi, Sung Hak Lee, Jeonghyun Kang, Tae Hyun Hwang
Publikováno v:
Cancer Research. 82:642-642
Histological distribution and density of tumor infiltrating lymphocytes (TILs) are known to be informative to cancer patients’ outcome. However, due to the heterogeneity and huge size of digitized pathology slides, it has been a challenging problem
Autor:
Andrew Thrasher, Samuel W. Brady, Yu Liu, Brent A. Orr, Roya Mostafavi, Scott G. Foy, Mark C. Wilkinson, Liza-Marie Johnson, Jinghui Zhang, Antonina Silkov, Lynn W. Harrison, David A. Wheeler, Elizabeth M Azzato, Chimene Kesserwan, Lu Wang, Armita Bahrami, Alberto S. Pappo, Stacy Hines-Dowell, Leslie Taylor, Regina Nuccio, Charles G. Mullighan, Manish Kubal, Yanling Liu, Joy Nakitandwe, Jay Knight, David W. Ellison, Elsie L. Gerhardt, Rose B. McGee, Scott Newman, Kim E. Nichols, Jeffery M. Klco, Jing Wang, Michael R. Clay, Michael N. Edmonson, James R. Downing, Xin Zhou, Sheila A. Shurtleff, Delaram Rahbarinia, Dale J. Hedges, Giles W. Robinson, Emily Quinn, Jamie L. Maciaszek, Jessica M. Valdez, Jiali Gu, Ching-Hon Pui, Kayla V. Hamilton, Michael Rusch, Zhaojie Zhang, Annastasia A. Ouma
Publikováno v:
Cancer Research. 81:642-642
Clinical genomic studies of pediatric cancer have primarily focused on specific tumor types or high-risk disease. In the Genomes for Kids study (NCT02530658) we used a three-platform sequencing approach, including whole genome (WGS), whole exome (WES
Autor:
Wenrong Zhou, Yong Cang, Daisuke Ogiya, Kenneth Wen, Lijie Xing, Teru Hideshima, Jiye Liu, Kenneth C. Anderson, Su Wang, Yu-Tzu Tai
Publikováno v:
Cancer Research. 80:642-642
The development of novel agents including immunomodulatory drugs (IMiDs) lenalidomide (Len) and pomalidomide (Pom) has improved patient outcome in multiple myeloma (MM); however, acquired resistance to IMiDs commonly underlies relapse of disease. Pre
Autor:
Yingao Zhang, Nerlyne Desravines, Dominic T. Moore, Paola A. Gehrig, Leslie H. Clark, Victoria L. Bae-Jump
Publikováno v:
Cancer Research. 79:642-642
Obesity and diabetes is associated with increased risk and worse outcomes in endometrial cancer (EC). Our previous work has found that obesity leads to more aggressive tumor behavior and a doubling of tumor size in EC mouse models. Thus, we explored
Autor:
Hye Seung Lee, Kyoung Un Park, Kyu Sang Lee, Sung-Bum Kang, H. J. Oh, Duck-Woo Kim, Soo Kyung Nam, Soo Hyun Seo
Publikováno v:
Cancer Research. 78:642-642
Introduction: We focused on the utility of the droplet digital polymerase chain reaction (ddPCR) for detecting c-MYC gene copy number (GCN) gain in cell-free plasma and tumor tissue of CRC patients. Methods: c-MYC GCN was determined by using dual-col
Autor:
Vivek Subbiah, Anil K. Sood, Milind Javle, Aung Naing, Funda Meric-Bernstam, Daniel D. Karp, Siqing Fu, David S. Hong, Sarina Anne Piha-Paul, Jonathan M. Kurie, Scott Kopetz, Filip Janku, Adi Diab, Alice Wu, Apostolia Maria Tsimberidou, Martin Gleeson, Helen Huang, Ed Kheder
Publikováno v:
Cancer Research. 77:642-642
Introduction: KRAS gene plays a major role in tumorigenesis, cell proliferation and survival. Yet, there has been no effective targeted therapy against KRAS mutation-mediated tumors. We hypothesized that KRAS can induce humoral-mediated immune respon
Autor:
Joydeep Bhadury, Jonas Nilsson, Roger Olofsson Bagge, Ulrika Stierner, Lars Ny, Marcela Dávila López, Agnieszka Podraza, Berglind Osk Einarsdottir
Publikováno v:
Cancer Research. 76:642-642
Cell line-derived xenografts (CDXs) are an integral part of drug efficacy testing during development of new pharmaceuticals against cancer but their accuracy in predicting clinical responses in patients have been debated. Patient-derived xenografts (
Autor:
Grace Chan, Michael B. Lilly, Maria N. Garnovskaya, Mary G. Blanton, Richard H. Weisbart, Nancy L. Goicochea
Publikováno v:
Cancer Research. 75:642-642
Androgen receptor (AR) plays a critical role in the development and progression of prostate cancer (PCa). Current therapies target the ligand-binding domain (LBD) of AR by inhibiting production or binding of ligand. In castration-resistant PCa (CRPC)
Autor:
Chris E. Adkins, Paul R. Lockman, Reinhard Gabathuler, Mohamed I. Nounou, Wilfred A. Jefferies, Timothy Z. Vitalis
Publikováno v:
Cancer Research. 74:642-642
Trastuzumab, a monoclonal antibody against HER2, is an effective therapy for the treatment of peripheral HER2+ breast cancer. However a significant number of patients eventually succumb to metastases of the brain because the endothelial tight junctio