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Autor:
Ji-Yeon Kim, Kyunghee Park, Woong-Yang Park, Jeong Eon Lee, Seok Won Kim, Seok Jin Nam, Jonghan Yu, Young-Hyuck Im, Jin Seok Ahn, Yeon Hee Park
Publikováno v:
Cancer Research. 82:P3-13
Background: Neutrotrophin receptor tyrosine kinase (NTRK) gene fusions (NTRK1, NTRK2, or NTRK3) are oncogenic drivers of various tumor types. The NTRK fusion was detected in less than 5% of breast, colorectal, lung or any other types of cancers. Howe
Publikováno v:
Cancer Research. 81:629-629
Rhabdomyosarcoma (RMS) is the most common soft-tissue sarcoma that is primarily observed in children and adolescent, and accounts for 50% of soft tissue sarcomas in children. There are two major forms of RMS, namely embryonal RMS (ERMS) and alveolar
Autor:
Caroline Y. Um, Marjorie L. McCullough, Mark A. Guinter, Susan M. Gapstur, Peter T. Campbell, Eric J. Jacobs
Publikováno v:
Cancer Research. 79:629-629
Coffee consumption is inconsistently associated with colorectal cancer (CRC) risk, and further research on potential differences in associations by sex, colorectal subsite, smoking status, and caffeinated/decaffeinated coffee is needed. To investigat
Autor:
Nikolai Kley, Sandra Van Lint, Geneviève Garcin, Anje Cauwels, Gilles Uzé, Jan Tavernier, Alexander Van Parys, Franciane Paul
Publikováno v:
Cancer Research. 78:629-629
An ideal generic cancer immunotherapy should mobilize the immune system to destroy tumor cells without harming healthy cells and remain active in case of recurrence. Furthermore, it should preferably not rely on tumor-specific surface markers, as the
Autor:
Jason Hudak, Tyler Murphy, Fujiko Duke, Brendan Bulik-Sullivan, Matthew M. Davis, Jessica Smith, Josh Francis, Andrew Clark, Roman Yelensky, Michele Busby, Jennifer Busby, Adnan Derti
Publikováno v:
Cancer Research. 77:629-629
Background: Immunotherapy has become essential in the treatment of advanced cancer, with the advent of drug approvals in multiple indications and functional cures for a minority of patients. However, overall survival gains from immunotherapy have bee
Autor:
Emma Leena Alarmo, Philip Owens, Agnes E. Gorska, Anne Kallioniemi, Riikka Havunen, Harold L. Moses, Minna Ampuja
Publikováno v:
Cancer Research. 76:629-629
Background. Breast cancer is the most common cancer in women worldwide. Bone morphogenetic proteins (BMPs), members of the transforming growth factor β superfamily, are known to regulate cell proliferation, differentiation and motility, and have als
Autor:
James Che, Derek E. Go, Edward B. Garon, Elodie Sollier, Jianyu Rao, Dino Di Carlo, Jonathan H. Goldman, Rajan P. Kulkarni, Corinne Renier, Nagesh Rao, Stefanie S. Jeffrey, Edward Pao
Publikováno v:
Cancer Research. 75:629-629
INTRODUCTION: The isolation of circulating tumor cells (CTCs) from the bloodstream is a promising tool for improving cancer prognosis, targeted therapies, and to understand the biology of metastatic processes. CTC analysis could benefit from conventi
Autor:
Krishna Shah, Todd Bartkowiak, Casey R. Ager, Midan Ai, Beatrisa Lerman, Michael A. Curran, Ashvin R. Jaiswal
Publikováno v:
Cancer Research. 74:629-629
Tumor hypoxia contributes to chemotherapy and radiotherapy resistance, and helps foster metastasis. Hypoxia likely also supports tumor immune resistance by supporting development of suppressive myeloid and T cell populations by activating immunosuppr
Autor:
Martin Mistrik, Jiri Bartek
Publikováno v:
Cancer Research. 73:629-629
Using an optimized cell-spreading technique combined with immunofluorescence (IF) and super-resolution microscopy we examined in greater detail DNA lesions induced within human mitotic chromosomes. We found some major differences in DNA damage signal