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pro vyhledávání: '"556"'
Autor:
Rebecca C. Larson, Ana Castano, Amanda A. Bouffard, Michael C. Kann, Andrea Schmidts, Kathleen M. Gallagher, Marcela V. Maus
Publikováno v:
Cancer Research. 82:556-556
Anti-BCMA CAR T cell therapy has had success clinically against multiple myeloma, recently leading to FDA approval. However, the median progression free survival is 8.8 months, suggesting that targeting BCMA alone may not be sufficient. Reports of BC
Autor:
John M. Maris, Laura E. Egolf, Diskin Sharon, Rebecca Kaufman, Alex Lee, Zalman Vaksman, Emily Blauel, Andrew F. Olshan
Publikováno v:
Cancer Research. 81:3030-3030
Background: Neuroblastoma is a childhood cancer that arises from the sympathetic nervous system. Approximately 1% of patients have a family history of disease with causal germline mutations in neuroblastoma predisposition genes, ALK or PHOX2B. Recent
Autor:
Richard E. Green, Christopher J. Troll, Abdullah Mahmood Ali, Camille Schwartz, Varsha Rao, Azra Raza, Charles J. Vaske, Kelly Harkins-Kincaid, Colin Naughton
Publikováno v:
Cancer Research. 81:556-556
DNA sequencing library preparation is a crucial step for next-generation sequencing of cell free DNA of plasma for cancer diagnostics. We present SRSLY, a robust single-stranded DNA library preparation method, that generates libraries with unique mol
Akademický článek
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Autor:
Elizabeth E. Hull, Brianna Flores
Publikováno v:
Cancer Research. 78:556-556
The tumor suppressor p53 protein is mutated in over 50% of cancers. The most frequent mutations in p53, termed “hotspot” mutations, occur in the DNA binding domain of the p53 protein. These mutations not only remove normal p53 function but also c
Autor:
Noreen R. Gonzales, Aron Marchler-Bauer, Stephen H. Bryant, Roxanne A. Yamashita, James S. Song
Publikováno v:
Cancer Research. 77:556-556
NCBI’s Conserved Domain Database (CDD, https://www.ncbi.nlm.nih.gov/Structure/cdd/cdd.shtml) is a resource that aims at classifying ancient conserved domain families and capturing what is known about their functional diversity. It is a collection o
Autor:
Gabriele Matschiner, Corinna Schlosser, Sven Berger, Marlon Hinner, Ulrich Moebius, Christine Rothe, Alexander Wiedenmann, Andrea Allersdorfer, Rachida-Siham Bel Aiba, Shane Olwill
Publikováno v:
Cancer Research. 76:556-556
Background. CD137 (4-1BB) is a key costimulatory immunoreceptor and a member of the TNF-receptor (TNFR) superfamily. While multiple lines of evidence show that CD137 is a highly promising therapeutic target in cancer, current mAb-based approaches are
Autor:
Kentaro Kishi, Yasuo Urata, Masaki Mori, Kenta Furukawa, Toshimitsu Irei, Masaki Wakasugi, Masashi Inoue, Shinya Yamashita, Yuichiro Doki, Masahiro Tanemura, Hiroaki Nagano, Nobuyoshi Hatanaka, Hiroki Akamatsu
Publikováno v:
Cancer Research. 75:556-556
Circulating tumor cells (CTCs) are thought to be “metastatic intermediates”. Recently, we reported encouraging survival rates following neoadjuvant therapy using gemcitabine (Gem) and S-1 concurrently with radiotherapy (NACRT) in patients (pts) w
Publikováno v:
Cancer Research. 74:556-556
Background: The pro-inflammatory cytokine, interleukin 32 (IL-32), is a novel tumor marker highly expressed in various human carcinomas including gastric cancer (GC). Materials and Methods: A total of 120 patients with gastric cancer undergoing gastr
Autor:
Hong Seok Choi, Karam Kim
Publikováno v:
Cancer Research. 73:556-556
Interleukin 22 (IL-22), a member of the IL-10 family of cytokines, is secreted T helper 17 (Th17) cells. Although IL-22 was recently reported to be a novel inflammation mediator through STAT3 signaling activation, the precise mechanisms of IL-22 in n