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Akademický článek
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Autor:
Huifen Zhou, Songhui Xu, Cancan Zhang, Qixin Leng, Hao-Wu Jiang, Jiaxi He, Donge Tang, Xin-Yan Geng, De-Xue Fu, Yong Dai, Rui Sun
Publikováno v:
Cancer Research. :OF1-OF15
The histone demethylase KDM6A controls gene expression by the epigenetic regulation of H3K27 methylation and functions in diverse processes, including differentiation, development, and cancer. Here, we investigated the role of KDM6A in prostate cance
Akademický článek
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K zobrazení výsledku je třeba se přihlásit.
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Autor:
Wenyi Fan, Dongxin Lin, Shaosen Zhang, Weiling Liu, Wen Tan, Xuan Zhao, Ai Lin, Xiangjie Niu, Chen Wu, Ping Ji, Yanxia Sun, Eric J. Wagner, Yamei Chen, Yachen Liu, Chuanwang Miao
Publikováno v:
Cancer Research. 81:5638-5651
The majority of human genes have multiple polyadenylation sites, which are differentially used through the process of alternative polyadenylation (APA). Dysregulation of APA contributes to numerous diseases, including cancer. However, specific genes
Autor:
Xintong Dai, Xiujuan Ding, Yanrong Liu, Jingxia Han, Wenqing Gao, Jia-Huan Yang, Hongqi Wang, Yuyan Yang, Tao Sun, Zihan Zhao, Yang Zhang, Huijuan Liu, Weilong Zhong
Publikováno v:
Cancer Research. 81:5353-5365
Although it is established that the sustained psychologic stress conditions under which patients with tumors often reside accelerates malignant progression of tumors, the molecular mechanism behind this association is unclear. In this work, the effec
Autor:
Hitoshi Maeda, Cheng Pan, Ryusei Tanaka, Hisakazu Komori, Yoshihiro Komohara, Taisei Nagasaki, Yukio Fujiwara, Shigeyuki Esumi, Toru Takeo, Toru Maruyama, Ayumi Mukunoki, Kotaro Matsusaka, Hiroshi Watanabe, Jing Bi, Yuka Nakamura, Daiki Yoshii, Koji Tamada, Yoichi Saito, Naomi Nakagata, Ryo Fukuda
Publikováno v:
Cancer Research. 81:4545-4559
Blood levels of acute-phase protein α1-acid glycoprotein (AGP, orosmucoid) increase in patients with cancer. Although AGP is produced from hepatocytes following stimulation by immune cell–derived cytokines under conditions of inflammation and tumo
Autor:
Kenta Terai, Yoshinobu Konishi, Yoko Hamazaki, Akifumi Takaori-Kondo, Yasuhiro Murakawa, Hiroshi Ichise, Shinya Tsukiji, Choji Oki, Michiyuki Matsuda, Tetsuya Watabe
Publikováno v:
Cancer Research. 81:4124-4132
Prostaglandin E2 (PGE2) promotes tumor progression through evasion of antitumor immunity. In stark contrast to cyclooxygenase-dependent production of PGE2, little is known whether PGE2 secretion is regulated within tumor tissues. Here, we show that V
Autor:
Molishree Joshi, Donna E. Hansel, Colin Sempeck, Lauren A. Vanderlinden, Dan Theodorescu, Joseph L. Sottnik, Charles Owens, Debashis Ghosh, Ana Chauca-Diaz
Publikováno v:
Cancer Research. 81:2833-2846
The androgen receptor (AR) is important in the development of both experimental and human bladder cancer. However, the role of AR in bladder cancer growth and progression is less clear, with literature indicating that more advanced stage and grade di
Autor:
Wei Tian, Zhiyuan Jiang, Chao Ge, Fangyu Zhao, Taoyang Chen, Tingting Huang, Jinjun Li, Tengfei Liu, Ying Cui, Hong Li, Hua Tian, Qingqing Zhou, Ming Yao
Publikováno v:
Cancer Research. 81:1361-1374
AKR1C3 is an enzyme belonging to the aldo-ketoreductase family, the members of which catalyze redox transformations involved in biosynthesis, intermediary metabolism, and detoxification. AKR1C3 plays an important role in tumor progression and metasta
Autor:
Ratna K. Vadlamudi, Kristin A. Altwegg, Weiwei Tang, Uday P. Pratap, Xiaonan Li, Junhao Liu, Suryavathi Viswanadhapalli, Zexuan Liu
Publikováno v:
Cancer Research. 81:PS17-34
BACKGROUND: Hyperactivation of PI3K/Akt signaling is implicated in breast cancer (BCa) progression. SETDB1, a methyltransferase, is also implicated in BCa, however, the mechanism remains elusive. Recent studies have shown SETDB1 can methylate non-his