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Autor:
Yu-Chun Lin, Fu-Tien Liao, Xiaoping Liu, George D. Leikauf, Phouthone Keohavong, Yuanpu Peter Di, Chia-Hsin Liu, Kong Chen, Chia-En Chung, Zhong Chen
Publikováno v:
Cancer Res
Chronic obstructive pulmonary disease (COPD) is an inflammatory disease that is associated with increased risk of lung cancer. Pseudomonas aeruginosa (PA) infections are frequent in patients with COPD, which increase lung inflammation and acute exace
Autor:
Seung-Ho Shin, Abhijit Chakraborty, Qiushi Wang, Souren Paul, Eunmiri Roh, Tianshun Zhang, Hisae Yoshitomi, Zigang Dong, H. S. Chen, Joohyun Ryu, Faisal Aziz, Ke Yao, Kun Y. Lee, Ann M. Bode
Publikováno v:
Cancer research. 81(4)
The Wilms' tumor 1 (WT1) gene is well known as a chameleon gene. It plays a role as a tumor suppressor in Wilms' tumor but also acts as an oncogene in other cancers. Previously, our group reported that a canonical AUG starting site for the WT1 protei
Publikováno v:
Cancer Res
Tight junction (TJ) proteins are essential for mediating interactions between adjacent cells and coordinating cellular and organ responses. Initial investigations into TJ proteins and junctional adhesion molecules (JAM) in cancer suggested a tumor-su
Autor:
Mei-Ying Liao, Jun-Kai Lai, Kai-Chi Chen, Yi-Ting Chuang, Han-Chung Wu, William Wei-Fu Tsuei, Shao-Hsi Hung, Kang-Hao Liang, Hao-Nien Chen, Chun-Hsin Lan
Publikováno v:
Cancer research. 80(22)
Although epithelial cell adhesion molecule (EpCAM) has previously been shown to promote tumor progression, the underlying mechanisms remain largely unknown. Here, we report that the EGF-like domain I within the extracellular domain of EpCAM (EpEX) bi
Publikováno v:
Cancer Res
Muscleblind-like proteins (MBNL) belong to a family of tissue-specific regulators of RNA metabolism that control premessenger RNA splicing. Inactivation of MBNL causes an adult-to-fetal alternative splicing transition, resulting in the development of
Publikováno v:
Cancer Res
GST omega 1 (GSTO1) is an atypical GST isoform that is overexpressed in several cancers and has been implicated in drug resistance. Currently, no small-molecule drug targeting GSTO1 is under clinical development. Here we have validated GSTO1 as an im
Autor:
Takahiro Osawa, Nako Maishi, Naoto Miyajima, Kyoko Hida, Kaname Ameda, Yoshihiro Matsuno, Masumi Sato, Ryo Takeda, Akira Kashiwagi, Hiroshi Kikuchi, Dorcas A. Annan, Mohammad Towfik Alam, Keita Ishizuka, Randa Dawood, Masahiro Morimoto, Katsushige Yamashiro, Nobuo Shinohara, Satoru Maruyama, Ryuji Matsumoto, Manabu Azuma, Kunihiko Tsuchiya, Tomoshige Akino, Yasuhiro Hida, Takashige Abe, Toru Harabayashi
Publikováno v:
Cancer research. 80(14)
Tumor endothelial cells (TEC) lining tumor blood vessels actively contribute to tumor progression and metastasis. In addition to tumor cells, TEC may develop drug resistance during cancer treatment, allowing the tumor cells to survive chemotherapy an
Autor:
Hellmut G. Augustin, Mahak Singhal
Publikováno v:
Cancer research. 80(4)
Looking beyond tumor angiogenesis, the past decade has witnessed a fundamental change of paradigm with the discovery that the vascular endothelium does not just respond to exogenous cytokines, but exerts active “angiocrine” gatekeeper roles, cont
Autor:
Carlo Sorrentino, Emma Di Carlo, Sara Caputo, Matteo Bellone, Stefania Livia Ciummo, Giuseppe Cipollone
Publikováno v:
Cancer Research. 78:2654-2668
Prostate cancer stem-like cells (PCSLC) are believed to be responsible for prostate cancer onset and metastasis. Autocrine and microenvironmental signals dictate PCSLC behavior and patient outcome. In prostate cancer patients, IL30/IL27p28 has been l
Autor:
Hong Zhao, Zhou Songyang, Dihua Yu, Min Li, Lin Zhang, Zhifen Zhou, Jing Chen, Ozgur Sahin, Jean J. Zhao
Publikováno v:
Cancer Research
The role of pyruvate kinase M2 isoform (PKM2) in tumor progression has been controversial. Previous studies showed that PKM2 promoted tumor growth in xenograft models; however, depletion of PKM2 in the Brca1-loss–driven mammary tumor mouse model ac