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Autor:
Ajeeth K. Pingili, Jared C Clements, Joseph F. Pierre, Mehdi Chaib, Neena A John, Emily B. Korba, Mary C Lovely, Laura M. Sipe, Liza Makowski
Publikováno v:
Cancer Research. 81:PS17-29
Background: Obesity leads to a higher risk of cancer invasion, metastases, recurrence, mortality, and impaired therapeutic response through various mechanisms. One of these mechanisms is microenvironment dysfunction, where changes in immune cells, mi
Autor:
You Wang, Pan Yin, Wei Qian, Liming Gui, Wei-Qiang Gao, Bin Ma, Zhongzhong Ji, Lu Ji, Guan Ning Lin
Publikováno v:
Cancer Research. 80:2004-2016
Dysregulation of Wnt/β-catenin signaling is frequently observed in human gastric cancer. Elucidation of the tumor immune microenvironment is essential for understanding tumorigenesis and for the development of immunotherapeutic strategies. However,
Autor:
Su Jin Jeong, Joon Won Lee, Young-Joon Surh, Jae Min Lim, Jeong-Hoon Jang, Do-Hee Kim, Kwang Pyo Kim
Publikováno v:
Cancer Research. 80:1342-1356
IL1β is a central regulator of systemic inflammatory response in breast cancer, but the precise regulatory mechanisms that dictate the overproduction of IL1β are largely unsolved. Here, we show that IL1β secretion is increased by the coculture of
Autor:
Christian Molnar, Melanie Boerries, Simone Schmid, Monilola A. Olayioye, Ismael Sánchez-González, Anja Bobien, Hauke Busch, Michaela Strotbek
Publikováno v:
Cancer Research. 80:1330-1341
Paracrine activation of cells contained in the tumor microenvironment promotes tumor progression and metastasis. In breast cancer, malignant cells recruit and educate macrophages into a M2 tumor–promoting phenotype that supports the metastatic spre
Autor:
Vladmir Cláudio Cordeiro de Lima, Mariana Petaccia de Macedo, Geraldine Eltz Lima, Monique Celeste Tavares, Daniel G Gonçalves, Victor P Andrande, Cristina D Sampaio
Publikováno v:
Cancer Research. 80:P3-08
Introduction: Triple-negative mammary carcinomas (CMTN) correspond to about 15 to 20%, the subtype being more aggressive when compared to the others. The interaction between immune system cells and cancer plays a crucial role in tumor development and
Autor:
Said Akli, Amriti R. Lulla, Taylor T. Chrisikos, Marc A. Pina, Stephanie S. Watowich, Yifan Zhou, Haiyan S. Li, Khandan Keyomarsi
Publikováno v:
Cancer Research. 80:P3-10
Background: Chronic inflammation, a hallmark of cancer, is associated with poor prognosis in human various malignancies. Predominantly, tumor associated neutrophils (TANs) and myeloid-derived suppressor cells (MDSCs) are immune cells well characteriz
Autor:
Stephen D. Hursting, Albert R. Davalos, Linda A. deGraffenried, Andrew Brenner, Brittany Harlow, Stefano Tiziani, Christopher A. Jolly
Publikováno v:
Cancer Research. 80:P1-08
Background: Approximately 40% of American women suffer from obesity, and about 1 in 8 women will be diagnosed with breast cancer during her lifetime. The concurrence of these trends has the potential to be particularly detrimental, as obesity confers
Autor:
Yanchao Liu, Yanni Chen, Zou Bin, Ma Shichao, Shaojun Liu, Xuejie Zhang, Dong Hongping, Hailong Zhang, Sheng Chen, Fu Xianlei, Lijing Kang
Publikováno v:
Cancer Research. 79:5587-5596
Aberrant activity of polycomb repressive complex 2 (PRC2) is involved in a wide range of human cancer progression. The WD40 repeat-containing protein EED is a core component of PRC2 and enhances PRC2 activity through interaction with H3K27me3. In thi
Autor:
Liang Weng, Makoto Matsuyama, Yukihiro Shiraki, Seiichiro Ishihara, Atsushi Masamune, Susan L. Woods, Kaori Ushida, Suguru Yamada, Hiroki Kobayashi, Hisashi Haga, Matthew W. Conklin, Nobutoshi Esaki, Mitsuhiro Fujishiro, Suzanne M. Ponik, Naoya Asai, Masahide Takahashi, Tongtong Wang, Tomoe Kobayashi, Akitoshi Hara, Tadashi Iida, Kenju Ando, Junpei Yamaguchi, Teppei Shimamura, Tsutomu Fujii, Takaki Miyata, Daniel L. Worthley, Atsushi Enomoto, Arata Nagasaka, Yoshiki Hirooka, Shinji Mii, Yasuyuki Mizutani
Publikováno v:
Cancer Research. 79:5367-5381
Cancer-associated fibroblasts (CAF) constitute a major component of the tumor microenvironment. Recent observations in genetically engineered mouse models and clinical studies have suggested that there may exist at least two functionally different po
Autor:
Gareth J. Veal, Philip Berry, Colin Kwok, Orli Yogev, Laura Danielson, Louis Chesler, Sally L George, Karen Barker, Neil J. Sebire, Barbara Martins da Costa, Till Möcklinghoff, Hannah Webber, James Campbell, Evon Poon, Gilberto S. Almeida, John Anderson, Magdalena Zarowiecki, Laura Mazzoli Smith, Stefano Lise, Elizabeth Calton, Albert Hallsworth, Bliss Buttery, Yann Jamin, Dimitrios Kleftogiannis, Simon P. Robinson
Publikováno v:
Cancer Research. 79:5382-5393
Neuroblastoma is a pediatric cancer that is frequently metastatic and resistant to conventional treatment. In part, a lack of natively metastatic, chemoresistant in vivo models has limited our insight into the development of aggressive disease. The T