Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Jeremy N. Rich"'
Autor:
Jinkyu Jung, Amber J. Giles, Orieta Celiku, Wei Zhang, Brian J. Williams, Roger Abounader, Jeremy N. Rich, Mark R. Gilbert, Deric M. Park, Ying Zhang, Hua Song
Publikováno v:
Cancer Research. 79:5218-5232
Cancer cells rely on mitochondrial functions to regulate key survival and death signals. How cancer cells regulate mitochondrial autophagy (mitophagy) in the tumor microenvironment as well as utilize mitophagy as a survival signal is still not well u
Publikováno v:
Cancer Research. 80:6611-6611
Glioblastoma is the most prevalent and aggressive primary brain tumor in adults, and conventional treatment strategies have made minimal progress in prolonging overall survival. Cancer stem cells are critical for tumor initiation, growth, and mainten
Autor:
Thomas T. Egelhoff, Jeremy N. Rich, Qiao Zheng, James S. Hale, Maksim Sinyuk, Baltin Otvos, Praveena S. Thiagarajan, Alvaro G. Alvarado, Ofer Reizes, Kevin Stoltz, Justin D. Lathia, Masahiro Hitomi, Dustin Thomas, Awad Jarrar
Publikováno v:
Cancer Research. 75:P2-06
Background : Advanced cancers including triple-negative breast cancer (TNBC), the most aggressive breast cancer subtype, contain a self-renewing, tumorigenic cancer stem cell (CSC) population. CSCs contribute to tumor progression and therapeutic resi
Autor:
Jeremy N. Rich
Publikováno v:
Cancer Research. 67:8980-8984
Highly tumorigenic subpopulations of several solid cancers share characteristics with somatic stem cells. We showed recently that cancer stem cells, or tumor-initiating cells, derived from human glioblastoma surgical specimens and xenografts display
Autor:
Youngmi Kim, Qiulian Wu, Gene H. Barnett, Anita B. Hjelmeland, Petra Hamerlik, Masahiro Hitomi, Robert J. Weil, Patrick Leahy, Jeremy N. Rich, Andrew E. Sloan
Publikováno v:
Cancer research. 73(15)
Glioblastomas display cellular hierarchies with self-renewing tumor-initiating cells (TIC), also known as cancer stem cells, at the apex. Although the TIC hypothesis remains controversial and the functional assays to define the TIC phenotype are evol
Autor:
Kyeung Min Joo, Hyunggee Kim, Juyoun Jin, Jeongwu Lee, Kwang Ho Cheong, Youn Jung Kang, Eunhee Kim, Bong Gu Kang, Ho Jun Seol, Doo Sik Kong, Paul H. Song, Kang Ho Kim, Jung Il Lee, Do-Hyun Nam, Justin D. Lathia, Yonghyun Kim, Jeremy N. Rich
Publikováno v:
Cancer research. 72(15)
Glioblastomas multiforme (GBM) contain highly tumorigenic, self-renewing populations of stem/initiating cells [glioblastoma stem cells (GSC)] that contribute to tumor propagation and treatment resistance. However, our knowledge of the specific signal
Publikováno v:
Cancer Research. 75:A45-A45
Purpose: Different cancer cell compartments often communicate through soluble factors to facilitate tumor growth. Glioma stem cells (GSCs) are a subset of tumor cells that resist standard therapy to contribute to disease progression. How GSCs employ
Autor:
Robert C. Rostomily, Alexis Hubaud, Robert L. Vessella, Julie Mathieu, Donald E. Born, Zhan Zhang, C. Anthony Blau, Bradford M. Stadler, Claudia M A Pinna, Wenyu Zhou, Michael Choi, Marshall S. Horwitz, Carol B. Ware, Merav Bar, John M. Heddleston, Amy Wang, Alvin Y. Liu, Hannele Ruohola-Baker, Jeremy N. Rich, Michele A. Cleary, Muneesh Tewari
Publikováno v:
Cancer research. 71(13)
Low oxygen levels have been shown to promote self-renewal in many stem cells. In tumors, hypoxia is associated with aggressive disease course and poor clinical outcomes. Furthermore, many aggressive tumors have been shown to display gene expression s
Autor:
Joseph R. Nevins, Jeremy N. Rich, Michael L. Gatza, Igor Shats, Seiichi Mori, Jeffrey T. Chang, Jialiang Wang
Publikováno v:
Cancer research. 71(5)
Given the very substantial heterogeneity of most human cancers, it is likely that most cancer therapeutics will be active in only a small fraction of any population of patients. As such, the development of new therapeutics, coupled with methods to ma
Autor:
Shideng Bao, Sith Sathornsumetee, Anita B. Hjelmeland, Hui Wang, Zhizhong Li, Qiulian Wu, Roger E. McLendon, Jeremy N. Rich
Publikováno v:
Cancer research. 68(15)
Malignant gliomas are lethal cancers that display striking cellular heterogeneity. A highly tumorigenic glioma tumor subpopulation, termed cancer stem cells or tumor-initiating cells, promotes therapeutic resistance and tumor angiogenesis. Therefore,