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Publikováno v:
Cancer Research. 81:PS6-46
Background Breast cancer is the second most common cancer in the world and most frequent among women. Tumor-infiltrating lymphocytes (TILs) can impact tumor progression and response to therapies. Here we aimed to study TILS using the International Im
Autor:
Ajeeth K. Pingili, Jared C Clements, Joseph F. Pierre, Mehdi Chaib, Neena A John, Emily B. Korba, Mary C Lovely, Laura M. Sipe, Liza Makowski
Publikováno v:
Cancer Research. 81:PS17-29
Background: Obesity leads to a higher risk of cancer invasion, metastases, recurrence, mortality, and impaired therapeutic response through various mechanisms. One of these mechanisms is microenvironment dysfunction, where changes in immune cells, mi
Autor:
Anwesha Chaudhury, Nuria Chic, Tetiana Taran, D. Martinez, Nadia Solovieff, Karen Rodriguez-Lorenc, Fara Brasó-Maristany, Aleix Prat, Faye Su, Laia Paré, Olga Martínez, Naveen Babbar
Publikováno v:
Cancer Research. 81:GS1-04
Background: The prognostic and predictive value of the 4 main intrinsic subtypes of breast cancer (ie, luminal A [LumA], luminal B [LumB], human epidermal growth factor receptor 2 enriched [HER2E], and basal-like) in hormone receptor-positive, HER2
Publikováno v:
Cancer Research. 80:P2-10
BACKGROUND. Outcome of breast cancer (BC) in African American females (AA) remains worse than Caucasian females (CA) after accounting for socioeconomic factors and tumor characteristics. Heterogeneity of tumor immune microenvironment (TIME) compositi
Autor:
Richard A. Larson, Rong Ye, Savitri Krishnamurthy, Shane R. Stecklein, Renae Van Whye, Randa El-Zein, Wendy A. Woodward, Jing Ning, Omar M. Rahal, Wintana Balema
Publikováno v:
Cancer Research. 80:P6-15
Introduction/Motivation: We previously reported IBC patients with limited breast-feeding history have a worse prognosis than those with greater breast feeding history. Further, we reported pregnancy related factors including multiple early pregnancie
Autor:
Josh Lauring, Mirat Shah, Jennifer Ensminger, Vered Stearns, Chenguang Wang, Siraj M. Ali, Ben Ho Park, Jon Chung
Publikováno v:
Cancer Research. 80:P6-10
Background: Activating HER2 missense mutations can develop in HER2-negative metastatic breast cancer, particularly in ER-positive disease. These mutations may be targeted with anti-HER2-directed therapy, providing a novel therapeutic option for women
Autor:
Chun Wang, Frederick M. Fellin, Darayus Toorkey, Kaelan Yao, Neha Pancholy, Saveri Bhattacharya, Maysa M. Abu-Khalaf, Ronald E. Myers, Rebecca Jaslow, Daniel P. Silver, Zhong Ye, AnaMaria Lopez, Hushan Yang, Zhenchao Zhang
Publikováno v:
Cancer Research. 80:P6-10
Background: Circulating tumor cells (CTCs) and their clusters (CTC-clusters) are promising prognostic markers in breast cancer. Recently studies showed that platelets interact with tumor cells in the circulation and promote metastasis. However, no st
Autor:
Helen Piwnica-Worms, Cullen M. Taniguchi, Anirban Maitra, Sonal Gupta, Meifang Yu, Amit Deorukhkar, Marimar de la Cruz Bonilla, Yanqing Huang, Charles V. Kingsley, Laura Baseler, Daniel Lin, Lauren E. Colbert, Eugene J. Koay, Tara N. Fujimoto, Gabriel O. Sawakuchi, Jessica M. Molkentine, Peter K. Cabeceiras, Ramesh C. Tailor
Publikováno v:
Cancer Res
When pancreatic cancer cannot be removed surgically, patients frequently experience morbidity and death from progression of their primary tumor. Radiation therapy (RT) cannot yet substitute for an operation because radiation causes fatal bleeding and
Autor:
G-U Woo, Wonshik Han, H-G Moon, M-S Jin, K-H Lee, D. Lee, Koung Jin Suh, Hj. Kim, Ia Park, T-Y Kim, H-B Lee, HS Ryu, D-Y Noh, Yil Suk Yang, S-A Im
Publikováno v:
Cancer Research. 79:P2-07
Background: Immune cells in the tumor microenvironment play an essential role in tumor progression and regression. However, immunologic characteristics and their prognostic role have not been clearly identified in breast cancer patients. This study a
Autor:
Francois Richard, M.J. Piccart, G Rouas, D. Larsimont, Diether Lambrechts, David R. Brown, Giancarlo Pruneri, Florian Clatot, S Majjaj, Bram Boeckx, C Desmedt, G. Van den Eynden, Caterina Marchiò, Françoise Rothé, Anne Vincent-Salomon, Odette Mariani, Christos Sotiriou, Christine Galant, Julien Pingitore, François Bertucci, Roberto Salgado
Publikováno v:
Cancer Research. 79:GS1-06
Background: Invasive lobular breast cancer (ILC) represents the second most common histology of breast cancer, accounts for 10-15% of all invasive cases and generally expresses the estrogen receptor (ER, coded by the ESR1 gene). Little is known about