Zobrazeno 1 - 10
of 453
pro vyhledávání: ''
Autor:
Chun Wang, Frederick M. Fellin, Darayus Toorkey, Kaelan Yao, Neha Pancholy, Saveri Bhattacharya, Maysa M. Abu-Khalaf, Ronald E. Myers, Rebecca Jaslow, Daniel P. Silver, Zhong Ye, AnaMaria Lopez, Hushan Yang, Zhenchao Zhang
Publikováno v:
Cancer Research. 80:P6-10
Background: Circulating tumor cells (CTCs) and their clusters (CTC-clusters) are promising prognostic markers in breast cancer. Recently studies showed that platelets interact with tumor cells in the circulation and promote metastasis. However, no st
Autor:
Tobias Xiao Dong, Rui Xie, Jingyu Xu, Hanxing Wan, Hui Dong, John M. Carethers, Ya-Han Fan, Jilin Wu, Bo Tang, Michael X. Zhu, Yu-Yun Wu, Jingjing Liu, Shi-Ming Yang, Suming Wang, Yu-Feng Xiao
Publikováno v:
Cancer Research. 77:6499-6512
Although dietary calcium intake has long been recommended for disease prevention, the influence of calcium in development of cancer in the upper gastrointestinal tract has not been explored. Here, we assess the roles of calcium and calcium-sensing re
Autor:
Yingjun Zhao, Jiwei Zhang, Zhixiang Hu, Ming Yao, Tao Yu, Hongyu Pan, Xianghuo He, Hechun Lin, Dandan Chu, Mingxia Yan, Jing Li, Shengli Li, Bing Chen, Zhe Li, Xiao Zhang, Lei Liu
Publikováno v:
Cancer Research. 77:5782-5794
Long noncoding RNAs (lncRNA) participate in carcinogenesis and tumor progression in lung cancer. Here, we report the identification of a lncRNA signature associated with metastasis of non–small cell lung cancer (NSCLC). In particular, elevated expr
Publikováno v:
Cancer Research. 77:P6-11
Triple-negative breast cancer (TNBC) accounts for 15-20% of breast cancer cases and is more prevalent among young women and African American women. Metastasis and chemoresistance remain significant challenges in TNBC. The development of targeted ther
Autor:
ES Hwang, Carlo C. Maley, Lorraine M. King, Elaine R. Mardis, Allison Hall, Y Ding, AG Rodrigo, Jeffrey R. Marks
Publikováno v:
Cancer Research. 77:P1-06
Purpose: Intratumoral heterogeneity is well recognized to be an important driver of treatment resistance and metastasis. We undertook this N of one study to measure the degree of heterogeneity in a single large preinvasive lesion with an invasive com
Autor:
David Balli, Christine A. Iacobuzio-Donahue, Jonathan Bermeo, Pichai Raman, Amy Zhang, Ian W. Folkert, Taiji Yamazoe, Erica L. Carpenter, Faiyaz Notta, Robert J. Norgard, Scott W. Lowe, Komal S. Rathi, Jinyang Li, Ben Z. Stanger, Max D. Wengyn, Timour Baslan, Ravikanth Maddipati, Ian D. Millstein, Michael J. LaRiviere
Publikováno v:
Cancer Research. 80:PO-071
Tumor heterogeneity - resulting from genetic and epigenetic alterations acquired during tumor progression - is a critical driver of phenotypic diversity in most cancers. A lethal consequence of tumor heterogeneity is the acquisition of metastatic tra
Autor:
Alexander Laskaris, Thupten Tsering, Julia V. Burnier, Goffredo Orazio Arena, Mohamed Abdouh, Prisca Bustamante Alvarez
Publikováno v:
Cancer Research. 80:6455-6455
Purpose: Extracellular vesicles (EVs) are small (50nm-800nm) membrane-enclosed structures with highly heterogeneous content. Recently, the importance of EVs in tumor progression as well as biomarkers has become apparent in many malignancies. However,
Autor:
Hernan G. Farina, Johanna E. Sidabra, Carla S. Capobianco, Maria F. Gottardo, Julio A. Aguirre Ghiso, Daniel F. Alonso
Publikováno v:
Cancer Research. 80:5983-5983
The p38 pathway can be activated by three different MAP kinase kinases: MKK3, MKK4 and MKK6, each one activated by different stimuli, like DNA damage, oxidative stress, proinflammatory cytokines or growth factors. In consequence, the responses mediat
Publikováno v:
Cancer Research. 80:3480-3480
Background: Physical activity (PA) is associated with a lower risk of colorectal cancer (CRC) initiation and death from CRC. However, evidence for a causal link between PA and disease progression is lacking. This study assesses the effect of voluntar
Autor:
Martin Reck, Heimo Mairbäurl, Karin Müller-Decker, Marvin Wäsch, Torsten Goldmann, Ekkehard Vollmer, Reiner Siebert, Swetlana Scheufele, Sofia Depner, Ruth Merkle, Ole Ammerpohl, Magdalena Szczygiel, Sebastian Marwitz, Philippe Lucarelli, Maren Kröger, Christian Kugler, Ursula Klingmüller, Dmytro Dvornikov, Klaus F. Rabe
Publikováno v:
Cancer Research. 76:3785-3801
Non–small cell lung cancer (NSCLC) is characterized by early metastasis and has the highest mortality rate among all solid tumors, with the majority of patients diagnosed at an advanced stage where curative therapeutic options are lacking. In this