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Autor:
Ajeeth K. Pingili, Jared C Clements, Joseph F. Pierre, Mehdi Chaib, Neena A John, Emily B. Korba, Mary C Lovely, Laura M. Sipe, Liza Makowski
Publikováno v:
Cancer Research. 81:PS17-29
Background: Obesity leads to a higher risk of cancer invasion, metastases, recurrence, mortality, and impaired therapeutic response through various mechanisms. One of these mechanisms is microenvironment dysfunction, where changes in immune cells, mi
Autor:
Anwesha Chaudhury, Nuria Chic, Tetiana Taran, D. Martinez, Nadia Solovieff, Karen Rodriguez-Lorenc, Fara Brasó-Maristany, Aleix Prat, Faye Su, Laia Paré, Olga Martínez, Naveen Babbar
Publikováno v:
Cancer Research. 81:GS1-04
Background: The prognostic and predictive value of the 4 main intrinsic subtypes of breast cancer (ie, luminal A [LumA], luminal B [LumB], human epidermal growth factor receptor 2 enriched [HER2E], and basal-like) in hormone receptor-positive, HER2
Autor:
Helen Piwnica-Worms, Cullen M. Taniguchi, Anirban Maitra, Sonal Gupta, Meifang Yu, Amit Deorukhkar, Marimar de la Cruz Bonilla, Yanqing Huang, Charles V. Kingsley, Laura Baseler, Daniel Lin, Lauren E. Colbert, Eugene J. Koay, Tara N. Fujimoto, Gabriel O. Sawakuchi, Jessica M. Molkentine, Peter K. Cabeceiras, Ramesh C. Tailor
Publikováno v:
Cancer Res
When pancreatic cancer cannot be removed surgically, patients frequently experience morbidity and death from progression of their primary tumor. Radiation therapy (RT) cannot yet substitute for an operation because radiation causes fatal bleeding and
Publikováno v:
Cancer Research. 81:3158-3159
Radiotherapy plays an important role in the management of pancreatic ductal adenocarcinoma (PDAC), especially when patients are not surgical candidates. Radiation-induced tumor death provokes an acute inflammation followed by a late-fibrotic response
Autor:
Jessica Liu, Paul Frankel, Marice Alcantara, Przemyslaw Twardowski, Marcin Kortylewski, Tanya B. Dorff, S.V. Dandapani
Publikováno v:
Cancer Research. 81:677-677
Prostate cancer is the second leading cause of death in men in the developed countries. Androgen deprivation therapy (ADT) is commonly used to treat prostate tumors at earlier stages due to hormone-dependence of cancer cells. However, the onset of an
Autor:
Finn Cilius Nielsen, Olga Oestrup, Ulrik Lassen, Hans Skovgaard Poulsen, Petra Hamerlik, Jane Skjøth-Rasmussen, Christina Westmose Yde, Dorte Schou Noeroexe
Publikováno v:
Cancer Research. 81:444-444
Introduction: Glioblastoma (GBM) is a heterogenous cancer with a high degree of intratumoral subclonality. We foresee that future treatment will be a combination of non-targeted and targeted therapies against molecular features of each patient. In or
Autor:
Mathieu Lupien
Publikováno v:
Cancer Research. 81:SP087-SP087
Standard-of-care therapy in high-risk stage II-III ER+/HER2-negative and Triple-Negative Breast Cancer (TNBC) includes neoadjuvant chemotherapy (NAC) prior to surgery, which is then followed by adjuvant endocrine (for ER+) +/- salvage chemotherapy (f
Autor:
Aaron N. Hata, Sophia C. Kamran, Florian J. Fintelmann, Clemens Grassberger, Lecia V. Sequist, Harald Paganetti, Yosef E. Maruvka, Zofia Piotrowska, Henning Willers, Changran Geng, David M. McClatchy
Publikováno v:
Cancer Res
The importance of preexisting versus acquired drug resistance in patients with cancer treated with small-molecule tyrosine kinase inhibitors (TKI) remains controversial. The goal of this study is to provide a general estimate of the size and dynamics
Autor:
Florence Vincent, Natacha Entz-Werle, Véronique Kemmel, Benoit Lhermitte, Sarah Jannier, Pierre Leblond, Consuelo Sebastia, Agathe Chammas, Amelia-Naomi Sabo, Anne Isabelle Bertozzi, Nicolas André, Birgit Geoerger, Françoise Farace, Isabelle Aerts, Yves Perel, Didier Frappaz, Erwan Pencreach, Nadège Corradini
Publikováno v:
Cancer Research. 80:CT136-CT136
Background: Hypoxic environment is a pejorative prognostic factor in pediatric solid tumors (ST). It is favoring neoangiogenesis, tumor progression and resistance to treatments through the activation of mTor and HIF-1α pathways. Those hypoxic marker
Autor:
Sanhita Rath, Jinghua Gu, Michael E. Berens, Sen Peng, Nicholas J. Schork, George Snipes, Harshil Dhruv, Jacob Cardenas, Xuan Wang, Karen Fink
Publikováno v:
Cancer Research. 80:2007-2007
Glioblastoma (GBM) is the most frequently reported primary malignant brain tumor (29.6%). The prognosis for patients who develop GBM is bleak, with average survival after diagnosis of 12-16 months. Although conventional treatment with surgery, irradi