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Autor:
Ajeeth K. Pingili, Jared C Clements, Joseph F. Pierre, Mehdi Chaib, Neena A John, Emily B. Korba, Mary C Lovely, Laura M. Sipe, Liza Makowski
Publikováno v:
Cancer Research. 81:PS17-29
Background: Obesity leads to a higher risk of cancer invasion, metastases, recurrence, mortality, and impaired therapeutic response through various mechanisms. One of these mechanisms is microenvironment dysfunction, where changes in immune cells, mi
Publikováno v:
Cancer Research. 81:3158-3159
Radiotherapy plays an important role in the management of pancreatic ductal adenocarcinoma (PDAC), especially when patients are not surgical candidates. Radiation-induced tumor death provokes an acute inflammation followed by a late-fibrotic response
Autor:
Elise Alspach, Andreas Sjödin, Yuanbo Qin, Sheila A. Stewart, Amey Barakat, Björn Nilsson, Irene Wong, Timothy Marsh, Jaclyn Sceneay, Sandra S. McAllister
Publikováno v:
Cancer Res
Triple-negative breast cancer (TNBC) is considered an early onset subtype of breast cancer that carries with it a poorer prognosis in young rather than older women for reasons that remain poorly understood. Hematopoiesis in the bone marrow becomes al
Autor:
Nancy Tray, Karen Hiotis, Deborah Axelrod, Victor Ty, Judith D. Goldberg, Farbod Darvishian, Maryann Kwa, Yelena Novik, Sylvia Adams, Amber A. Guth, James L. Speyer, Adriana Heguy, Douglas K. Marks
Publikováno v:
Cancer Research. 80:OT1-01
BACKGROUND: Receptor activator of NF-kB (RANK) and its ligand (RANKL) have a well-established role in osteoclast-driven bone remodeling, however RANK/RANKL expression can also be seen on mammary epithelial cells and immune cells (IC). In breast cance
Autor:
Christian G. Stief, Harald Hessel, Günter Schmidt, Nathalie Harder, Thomas Kirchner, Ralf Huss, Maria Athelogou, Tze Heng Tan, Alexander Buchner
Publikováno v:
Cancer Research. 78:A069-A069
Introduction: The composition of different immune cell populations in the tumor microenvironment plays an important role for tumor progression in various cancer types. In particular, tumor-associated macrophages (TAMs) and tumor-infiltrating T cells
Autor:
Rakesh K. Jain
Publikováno v:
Cancer Research. 77:IA01-IA01
For more nearly four decades, our research has focused on one challenge: improving the delivery and efficacy of anti-cancer therapies. Working on the hypothesis that the abnormal tumor microenvironment fuels tumor progression and treatment resistance
Publikováno v:
Cancer Research. 76:B27-B27
Cell-cell interactions within the tumor microenvironment play critical roles in tumor progression and its response to various therapies. Specifically in the case of pancreatic cancer, pancreatic cancer cells (PCCs) act on pancreatic stellate cells (P
Autor:
Daniel G. Anderson, James V. McCann, Lin Xiao, Piotr S. Kowalski, Omar F. Khan, Salma H. Azam, Andrew C. Dudley, Chad V. Pecot
Publikováno v:
Cancer Research. 76:A47-A47
Tumor-associated endothelial cells (TECs) are dysfunctional and leak fibrin which is resolved (fibrinolysis) and replaced with collagen in a process that closely resembles wound healing. Because degraded perivascular fibrin also promotes angiogenesis
Autor:
Howard J. Jacob, M.W. Straza, Michael J. Flister, Angela Lemke, Anne Frei, Amy Rymaszewski, Shirng-Wern Tsaih, Carmen Bergom
Publikováno v:
Cancer Research. 76:B07-B07
Progress in elucidating the molecular basis of breast cancer has allowed for treatment breakthroughs such as anti-estrogen and Her2-targeted therapy. It has also shaped the approaches to both surgical and systemic therapy. However, no similar use of
Publikováno v:
Cancer Research. 76:C09-C09
The breast tumor microenvironment (TME) is a diverse area where complex interactions between the extra-cellular matrix (ECM) and multiple cell types (tumor epithelial, endothelial, and inflammatory cells, fibroblasts, and adipocytes) occur resulting