Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Roller A"'
Autor:
Carrigan Wasilchenko, Piotr G. Rychahou, Eun Y. Lee, B. Mark Evers, Matthew L. Melton, Nicole Rychagov, Nick Roller
Publikováno v:
Cancer Research. 79:1121-1121
Colorectal cancer (CRC) is the second leading cause of cancer deaths in the US; systemic metastasis to the lungs occurs in approximately 10-20% of patients with CRC. Hepatocyte growth factor (HGF) and its tyrosine kinase receptor Met play a pivotal r
Autor:
Peter Bruenker, Esther Abraham, Stefanie Lechner, Suzana Vega-Harring, Meher Majety, Sabine Bader, Katharina Wartha, Andreas Roller, Hadassah Sade, Thomas Friess, Ann-Marie Broeske, Oliver Krieter
Publikováno v:
Cancer Research. 75:952-952
Background: Activation of the extrinsic apoptotic pathway by TRAIL is dependent on clustering of death receptors (DR) on the surface of cells. However, current TRAIL-based strategies have proven ineffective in clustering death receptors and failed to
Autor:
Stefan Bekiranov, Michael J. Weber, Aaron J. Mackey, Dan Gioeli, Devin G. Roller, Brian J. Capaldo, Mark J. Axelrod, Alexander F. Koeppel
Publikováno v:
Cancer Research. 74:4166-4166
Integrated molecular profiling of melanoma cell lines reveals genotype-drug phenotype associations giving insight on development of combination therapies Adaptive survival responses to targeted therapy reduce therapeutic benefit, and thus there is a
Autor:
Michael J. Weber, Daniel Gioeli, Devin G. Roller, Aaron J. Mackey, Brian J. Capaldo, Mark R. Conaway
Publikováno v:
Cancer Research. 73:3400-3400
BRAF is mutationally activated in 50% of melanomas with a variety of data indicating its role as a driver of malignancy. However, while patients with BRAF mutations respond to vemurafenib, most responses are not long lasting. Moreover, the 25% of mel
Publikováno v:
Cancer Research. 70:3843-3843
Cellular signals are not necessarily transmitted via linear pathways, but through a dynamic interconnected network. Effective pharmacologic inhibition of cellular signaling in malignant cells will thus require identifying the key nodes, and interveni
Autor:
S. Darb-Esfahani, Ralph M. Wirtz, G. von Minckwitz, C Denkert, S. Loibl, Martina Komor, R Kronenwett, B. M. Müller, Marc Roller, C. von Toerne
Publikováno v:
Cancer Research. 69:1070
CTRC-AACR San Antonio Breast Cancer Symposium: 2008 Abstracts Abstract #1070 Background: There are several methods for determination of HER2 overexpression. Immunohistochemistry (IHC) has been set up as the gold standard in routine diagnostics to ide