Zobrazeno 1 - 10
of 51
pro vyhledávání: '"35"'
Publikováno v:
Cancer Research. 78:35-35
There is strong evidence implicating exosomes, cell-derived nanoscale vesicles, and their protein cargo in facilitating dialogue between primary tumor cells and the premetastatic niche. Identified by our lab as one such protein, secreted nucleoside d
Autor:
David Miles, Matthew Kent, Kenneth Russell, Mary K Downer, Patricia Luhn, Joyce O'Shaughnessy
Publikováno v:
Cancer Research. 80:P2-15
Background: Corticosteroids (CS) have immunosuppressive properties that may diminish the efficacy of cancer immunotherapy (CIT). In retrospective analyses of clinical trial data, the use of CS for immune-mediated adverse events after starting CIT doe
Autor:
Valeria Caceres, H Ursino, Eduardo Gonzalez, D Bequelman, O Sturla, Maria Dolores Mansilla Figueroa, J Cavallero
Publikováno v:
Cancer Research. 80:P6-08
Background: Argentina is a country with inequalities in terms of healthcare, specially in genetics diseases. The lack of knowledge about hereditary cancer, the small number of genetic counselors and the difficulty of access to genetic testing are bar
Autor:
V. Valero, Beatriz E. Adrada, Michael Z. Gilcrease, Rosalind P. Candelaria, Debu Tripathy, Senthil Damodaran, Rachel M. Layman, Lumarie Santiago, Alastair M. Thompson, Lei Huo, Gabriel N. Hortobagyi, S. L. Moulder, Ravi Murthy, Bora Lim, Helen Piwnica-Worms, Fraser Symmans, KR Hess, Carlos H. Barcenas, EA Mittendorf, Wei Tse Yang, Gaiane M. Rauch, Akshara Singareeka Raghavendra, Clinton Yam, NT Ueno, Thorunn Helgason, Jennifer K. Litton
Publikováno v:
Cancer Research. 79:P1-15
Background: Serial biopsies (bx) of triple-negative breast cancer (TNBC) in the curative neoadjuvant setting provides critical information on dynamic changes in the tumor in response to neoadjuvant systemic therapy (NAST) and can help inform the deve
Autor:
Henry L. Gomez, Daniel J Enriquez, Eduardo Eyzaguirre, Silvia P. Neciosup, Renato Luque, Joseph A. Pinto, Hugo Fuentes, Antonella Saavedra, Maria Lujan, Zaida Morante, G De la Cruz-Ku
Publikováno v:
Cancer Research. 78:P1-15
Background: Triple-negative breast cancer (TNBC) in young and older patients has specific features and outcomes. While in younger patients, it is characterized by being aggressive with worse survival, in advanced ages it may have a better outcome whi
Autor:
John Pollard, Penney, Sara M. Tolaney, H.-T. Arkenau, Geoffrey I. Shapiro, C. Murias, Simon Lord, Emma Dean, G. Conboy, Rui Tang, Carlos Becerra, Melinda L. Telli, Vandana G. Abramson, S.Z. Fields
Publikováno v:
Cancer Research. 78:OT2-07
Background: ATR is a critical regulator of the cellular response to replication stress; it signals DNA damage repair, mediated through homologous recombination. Many cancers depend on ATR to survive DNA damage. M6620 is a potent, selective inhibitor
Autor:
Zaida Morante, Eduardo Eyzaguirre, Antonella Saavedra, G De la Cruz-Ku, Maria Lujan, Daniel J Enriquez, Silvia P. Neciosup, Henry L. Gomez, M Ramirez, Hugo Fuentes, Jhajaira M. Araujo, Joseph A. Pinto
Publikováno v:
Cancer Research. 78:P3-10
Background: The incidence of breast cancer (BC) is low in young women and is characterized by a high prevalence of triple-negative tumors, representing a group of high risk. In this work, we describe the clinicopathological and epidemiological featur
Autor:
John G. Kuhn, Virginia G. Kaklamani, Joe Ensor, Anna Belcheva, Kartik Anand, Luz A. Venta, Nakul Gupta, Yitian Xu, Ping-Ying Pan, Mary R. Schwartz, Andrew W. Chung, Tejal Patel, Shu-Hsia Chen, Angel Rodriguez, Jorge Darcourt, Polly A. Niravath, Nabeel Attarwala, Qiuying Chen, Eric H. Bernicker, Licheng Zhang, Wei Qian, Jenny C. Chang
Publikováno v:
Cancer Research. 81:CT175-CT175
Targeting inducible nitric oxide in a first-in-class phase 1/2 trial in triple-negative breast cancer patients diminishes M2 macrophage polarization and led to a robust clinical response. Andrew W. Chung*, Kartik Anand*, Polly Niravath* (co-first aut
Autor:
Natacha Duquette, Alain Zgheib, Jean-Christophe Currie, Alain Larocque, Michel Demeule, Cyndia Charfi, Christian Marsolais, Richard Béliveau, Borhane Annabi
Publikováno v:
Cancer Research. 80:2910-2910
Rational: Breast cancers are comprised of several subtypes that share similar clinicopathological features, but that also exhibit several different biological characteristics. Triple-negative breast cancer (TNBC), which comprises 10-20% of breast can
Publikováno v:
Cancer Research. 76:P1-07
Breast cancer is very rare in young women and has a more aggressive biological behavior and a worse prognosis than in older premenopausal women. This study was designed to determine and evaluate the features of breast cancer in young patients less th