Zobrazeno 31 - 40
of 483
pro vyhledávání: '"11"'
Autor:
A. Karim Ahmed, Stephanie Glavaris, Trinity J. Bivalacqua, John Shin, Emily A. Caruso, Kenneth J. Pienta, Heather J. Chalfin, Noah M. Hahn, Eric S. Christenson, Liang Dong, Michael H. Johnson, Michael A. Gorin, Megan H. Fong, David J. McConkey
Publikováno v:
Cancer Research. 78:1592-1592
Background: "Liquid biopsies" such as circulating tumor cells (CTCs) aim to monitor response to therapy or provide a noninvasive measure of disease progression. In bladder cancer, it is not known to what extent CTC counts fluctuate over time during t
Autor:
Silvia C. Formenti
Publikováno v:
Cancer Research. 78:PL1-PL1
Radiotherapy (RT) has revealed an ideal adjuvant to cancer immunotherapy, because of it's ability to convert the irradiated tumor into an individualized, in situ vaccine. 1 DNA damage response (DDR) contributes to immune rejection of tumors, a mechan
Publikováno v:
Cancer Research. 78:P5-05
Background: Massively parallel DNA sequencing efforts have facilitated the production of catalogs of the somatic mutations present in cancer genomes. Examining the sequence context of the mutations it is possible to identify patterns that recur frequ
Autor:
Francis J. Giles, Andrey Ugolkov, Timothy Taxter, Andrew P. Mazar, Sandeep Samant, Maria Matsangou
Publikováno v:
Cancer Research. 77:1127-1127
Background: Recurrent/metastatic head and neck squamous cell carcinoma (SCCHN) and salivary gland malignancies are difficult to treat with limited standard of care options at the present time. Glycogen Synthase Kinase-3beta (GSK-3beta), a serine/thre
Autor:
Marc E. Lippman, Paolo Serafini, AC De la Fuente, S Speransky, Silvio Bicciato, Dorraya El-Ashry, Nanette H. Bishopric
Publikováno v:
Cancer Research. 77:P6-01
Background: Prostate and breast cancers are, respectively, the most common malignancies diagnosed in men and women worldwide. These cancers develop in different organs but have significant biological similarities: both are typically hormone-dependent
Autor:
M Grünert, Volkmar Müller, Annette Lebeau, Carsten Bokemeyer, E Burandt, Fritz Jänicke, Waldemar Wilczak, Guido Sauter, Matthias Choschzick, Ronald Simon
Publikováno v:
Cancer Research. 71:P3-05
Background: Amplification of Cyclin D1 (CCND1) occurs in about 10–20% of breast cancers and has been suggested to predict resistance to anti-hormonal therapy. As the diagnostic accuracy of predictive biomarkers can be substantially limited by regio
Autor:
Nathaniel D. Anderson, Jonathan D. Wasserman, Ana Stosic, Fabio Fuligni, Evan J. Propst, Scott Davidson, Nikolaus E. Wolter, Meryl Acker, Richard de Borja, Ozgur Mete, Rose Chami, Adam Shlien, Vito Forte, David Malkin, Paolo Campisi
Publikováno v:
Cancer Research. 81:5625-5637
Pediatric papillary thyroid carcinoma (PPTC) is clinically distinct from adult-onset disease. Although there are higher rates of metastasis and recurrence in PPTC, prognosis remains highly favorable. Molecular characterization of PPTC has been lackin
Autor:
Richard J. Barth, Stephanie Her, Jinyoung Byun, David C. Qian, Christopher I. Amos, Xiangjun Xiao, Arief A. Suriawinata
Publikováno v:
Cancer Research. 76:2233-2233
Purpose: We have previously demonstrated that metastatic colorectal cancer patients who exhibit immune responses to a dendritic cell (DC) vaccine have superior recurrence-free survival following surgery, compared to patients in whom immune responses
Autor:
Ben Panizza, Janice Tsang, Corey Smith, V. Lee, Rajiv Khanna, Andrea Schuessler, John M. Nicholls, Leone Beagley, Sandro V. Porceddu, Dora L.W. Kwong
Publikováno v:
Cancer Research. 76:CT136-CT136
Epstein-Barr virus (EBV)-associated nasopharyngeal carcinoma (NPC) is endemic in regions of South-East Asia, with incidence as high as 25-50 cases per 100,000 people in southern China. While current standard therapy is curative for a subset with stag
Autor:
Thomas Cosgriff, Marc R. Matrana, Lee Roy Morgan, Marcus L. Ware, Craig Gordon, Roy S. Weiner, R. Kawauchi, Tallat Mahmood, J-J Zou, G. Bastian, Andrew H. Rodgers
Publikováno v:
Cancer Research. 76:CT129-CT129
Background: 4-Demethyl-4-cholesteryloxycarbonylpenclomedine (DM-CHOC-PEN) is a poly-chlorinated pyridine cholesteryl carbonate with a MOA via bis-alkylation of DNA @ N7-guanine and N4-cytosine that has completed a Phase I study [AACR #1185, 2013] and