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Autor:
Ling Cen, Sweta Dash, Andrew Smith, Sean Yoder, Chaomei Zhang, Tania Mesa, Guillermo N. Armaiz-Pena, Alvaro N.A. Monteiro, Jamie K. Teer
Publikováno v:
Cancer Research. 81:736-736
Chronic stress induced by repetitive activation of the sympathetic nervous system leads to rapid release of catecholamines like norepinephrine (NE). Several studies have shown that increased levels of NE can contribute to tumor progression by promoti
Autor:
Alexander Laskaris, Thupten Tsering, Julia V. Burnier, Goffredo Orazio Arena, Mohamed Abdouh, Prisca Bustamante Alvarez
Publikováno v:
Cancer Research. 80:6455-6455
Purpose: Extracellular vesicles (EVs) are small (50nm-800nm) membrane-enclosed structures with highly heterogeneous content. Recently, the importance of EVs in tumor progression as well as biomarkers has become apparent in many malignancies. However,
Autor:
Gema Silván, Juan Carlos Illera, W.A. Woodward, Sara Caceres, JM Reuben, Maria J. Illera, Laura Peña, B. Monsalve
Publikováno v:
Cancer Research. 77:P3-05
Background: Inflammatory breast carcinoma (IBC) is a special type of breast cancer with a poor survival rate and accounts for 6% of diagnosed breast cancers. The role of androgens on breast cancer is on rise in research, trying to propose anti-androg
Autor:
Clayton L. Davis, Samantha G. Pattenden, Dae Joong Kim, Xia Xu, Alissa K. Vanderlinden, James V. McCann, Keith Burridge, Nuo Xu, James M. Dunleavey, Mark W. Onaitis, Andrew C. Dudley, Elizabeth Monaghan-Benson, Lin Xiao, Stephen V. Frye
Publikováno v:
Cancer Research. 75:1244-1254
Endothelial-to-mesenchymal transition (EndMT) occurs during development and underlies the pathophysiology of multiple diseases. In tumors, unscheduled EndMT generates cancer-associated myofibroblasts that fuel inflammation and fibrosis, and may contr
Autor:
Chuan Hang Yu, Ming Yung Chou, Wen Liang Lo, Cheng Chia Yu, Mong Lien Wang, Yun Ching Chang, Guang-Yuh Chiou, Lo Lin Tsai, Shih Hwa Chiou
Publikováno v:
Cancer Research. 73:3425-3440
ALDH1+CD44+ cells are putative tumor-initiating cells (TIC) in head and neck squamous cell carcinomas (HNC). miR-145 regulates tumorigenicity in various cancers but the breadth of its mechanistic contributions and potential therapeutic applications a
Autor:
Frits Thorsen, Arvid Lundervold, Eva Syková, Pavla Jendelova, Kai Ove Skaftnesmo, Inderjit Daphu, Rolf Bjerkvig, Michal Babic, Ingvild Wendelbo, Heike Immervoll, Terje Sundstrøm, Erlend Hodneland, Morten Lund-Johansen
Publikováno v:
Cancer Research. 73:2445-2456
Biologic and therapeutic advances in melanoma brain metastasis are hampered by the paucity of reproducible and predictive animal models. In this work, we developed a robust model of brain metastasis that empowers quantitative tracking of cellular dis
Autor:
Caroline Bouzin, Olivier Feron, Christian Kupatt, Marc Dieu, Antonis K. Hatzopoulos, Florence Defresne, Marie Grandjean, Martine Raes
Publikováno v:
Cancer Research. 71:4748-4757
Tumor progression is associated with the release of signaling substances from the primary tumor into the bloodstream. Tumor-derived cytokines are known to promote the mobilization and the recruitment of cells from the bone marrow, including endotheli
Autor:
James D. Orth, Rainer H. Kohler, Peter K. Sorger, Floris Foijer, Timothy J. Mitchison, Ralph Weissleder
Publikováno v:
Cancer Research, 71(13), 4608-4616. AMER ASSOC CANCER RESEARCH
Cancer relies upon frequent or abnormal cell division, but how the tumor microenvironment affects mitotic processes in vivo remains unclear, largely due to the technical challenges of optical access, spatial resolution, and motion. We developed high-
Autor:
Barbara Pratscher, Rainer Kunstfeld, Hubert Pehamberger, Silvia Kremling, Teresa Valero, Peter Petzelbauer, Robert Loewe
Publikováno v:
Cancer Research. 66:11888-11896
Dimethylfumarate (DMF) inhibits signals transmitted by Rel proteins and is used for the treatment of inflammatory skin diseases such as psoriasis, but potential effects of DMF on tumor progression have yet not been analyzed. We show that DMF reduced
Autor:
Min Chen, Yang Li, Scott D. Jewell, Clay B. Marsh, Ronald Glaser, Stanley Lemeshow, Timothy D. Eubank, Peir En Yeh, Nicholas A. Flavahan, Eric V. Yang, Anil K. Sood, Carl Morrison
Publikováno v:
Cancer Research. 66:10357-10364
Recent studies using ovarian cancer cells have shown that the catecholamine hormones norepinephrine (norepi) and epinephrine (epi) may influence cancer progression by modulating the expression of matrix metalloproteinases (MMP) and vascular endotheli