Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Geethu E. Thomas"'
Autor:
Neil MacLean, Elias Orouji, Kerstin B. Kaufmann, Rose Hurren, Mark D. Minden, Aaron Botham, Veronique Voisin, Grace Egan, Geethu E. Thomas, Boaz Nachmias, Rashim Pal Singh, John E. Dick, Marcela Gronda, Jordan Chin, Dilshad H. Khan, Gary D. Bader, Laura Gracia Prat, Aaron D. Schimmer, Andrea Arruda, Xiaoming Wang
Publikováno v:
Cancer Research. 81:3099-3099
Mitochondrial metabolites affect epigenetic marks, but it is largely unknown whether mitochondrial metabolic enzymes can directly localize to the nucleus to regulate stem cell function in AML. Here, we discovered that the mitochondrial enzyme, Hexoki
Autor:
Aaron D. Schimmer, Jordan Chin, Razq Hakem, Grace Egan, Aaron Botham, Parasvi S. Patel, Geethu E. Thomas, Rose Hurren, Neil MacLean
Publikováno v:
Cancer Research. 80:3784-3784
Leukemia stem cells are responsible for the initiation and recurrence of AML. Cell differentiation requires the coordination of metabolic state and gene expression programs. It is known that metabolic intermediates can serve as cofactors in epigeneti