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Publikováno v:
Cancer Research. 80:6471-6471
Although Epithelial-Mesenchymal Transition (EMT) in cancers remains controversial, its relevance in tumor progression is a subject of investigation. The presence of cellular changes associated with EMT in bladder tumor progression have been well inve
Autor:
Alexander Laskaris, Thupten Tsering, Julia V. Burnier, Goffredo Orazio Arena, Mohamed Abdouh, Prisca Bustamante Alvarez
Publikováno v:
Cancer Research. 80:6455-6455
Purpose: Extracellular vesicles (EVs) are small (50nm-800nm) membrane-enclosed structures with highly heterogeneous content. Recently, the importance of EVs in tumor progression as well as biomarkers has become apparent in many malignancies. However,
Autor:
Chuan Hang Yu, Ming Yung Chou, Wen Liang Lo, Cheng Chia Yu, Mong Lien Wang, Yun Ching Chang, Guang-Yuh Chiou, Lo Lin Tsai, Shih Hwa Chiou
Publikováno v:
Cancer Research. 73:3425-3440
ALDH1+CD44+ cells are putative tumor-initiating cells (TIC) in head and neck squamous cell carcinomas (HNC). miR-145 regulates tumorigenicity in various cancers but the breadth of its mechanistic contributions and potential therapeutic applications a
Autor:
James D. Orth, Rainer H. Kohler, Peter K. Sorger, Floris Foijer, Timothy J. Mitchison, Ralph Weissleder
Publikováno v:
Cancer Research, 71(13), 4608-4616. AMER ASSOC CANCER RESEARCH
Cancer relies upon frequent or abnormal cell division, but how the tumor microenvironment affects mitotic processes in vivo remains unclear, largely due to the technical challenges of optical access, spatial resolution, and motion. We developed high-
Autor:
Cornelia L. Trimble, Rork Kuick, Bin Nan, Eric R. Fearon, Yali Zhai, Ichiro Ota, Kathleen R. Cho, Stephen J. Weiss
Publikováno v:
Cancer Research. 67:10163-10172
If left untreated, a subset of high-grade squamous intraepithelial lesions (HSIL) of the cervix will progress to invasive squamous cell carcinomas (SCC). To identify genes whose differential expression is linked to cervical cancer progression, we com
Autor:
Douglas D. Boyd, Takamitsu Sasaki, Lin Yang, Hector Avila, Gary E. Gallick, Heng Wang, Jose G. Trevino, Yasuhiko Kitadai
Publikováno v:
Cancer Research. 66:7957-7967
It is becoming increasingly clear that tumor growth and progression is not entirely due to genetic aberrations but also reflective of tumor cell plasticity. It follows therefore that proteins contributing to tumor progression oscillate in their expre
Autor:
Ichiro Yoshino, Kazunori Nakagawa, Katsuo Sueishi, Shinji Okano, Shihoko Sata, Takaomi Koga, Toshiaki Nakano, Mitsuho Onimaru, Yoshikazu Yonemitsu, Yoshihiko Maehara, Yasunori Shikada
Publikováno v:
Cancer Research. 65:7241-7248
It is widely accepted that angiogenesis is required for tumor progression. Vascular endothelial growth factor (VEGF) is a key molecule for tumor angiogenesis; however, its expressional regulation is not well understood during all stages of tumorigene
Autor:
Keiichi Isaka, Hirotaka Nishi, Akihiro Umezawa, Kosuke Oikawa, Tohru Kiyono, Masahiko Kuroda, Kiyoshi Mukai, Tetsuya Ohbayashi
Publikováno v:
Cancer Research. 64:3545-3549
In Drosophila melanogaster, the wings apart-like (wapl) gene encodes a protein that regulates heterochromatin structure. Here, we characterize a novel human homologue of wapl (termed human WAPL; hWAPL). The hWAPL mRNA was predominantly expressed in u
Autor:
Neysharie Sanchez, Eva C. Romero-Nutz, Aditi Banerjee, Krishna Baksi, Dipak K. Banerjee, Jesus E. Serrano
Publikováno v:
Cancer Research. 77:4509-4509
GRP78 (Mr78 kDa) is a glucose regulated protein. It is a member of the heat-shock protein (HSP) family but located in the lumen of the endoplasmic reticulum (ER). Its function as ER chaperone translocating protein across the ER membrane that needs to
Publikováno v:
Cancer Research. 77:4569-4569
Introduction: The immune system plays an important role in tumor progression and treatment response such as with new immune modulating therapies. It is unclear in lung cancer what the effect of smoking is upon intratumoral immune cell composition and