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Autor:
Michael C. Haffner, Paula J. Hurley, John T. Isaacs, Tamara L. Lotan, Brian W. Simons, Jessie Huang, Isla P. Garraway, Samantha Torquato, Elana J. Fertig, Daniel L.J. Thorek, W. Nathaniel Brennen, Elai Davicioni, Steven S. An, Hamda Khan, Valentina Kugler, Ben Ho Park, Debebe Theodros, Rebecca E. Miller, Robert M. Hughes, Ryan C. Riddle
Publikováno v:
Cancer Res
Tumor progression to metastasis is not cancer cell autonomous, but rather involves the interplay of multiple cell types within the tumor microenvironment. Here we identify asporin (ASPN) as a novel, secreted mesenchymal stromal cell (MSC) factor in t
Autor:
Hilla Solomon, Yoav Shetzer, Ron Rotkopf, Shay Eizenberger, Naomi Goldfinger, Varda Rotter, Alina Molchadsky, Giuseppe Lonetto, Gabriela Koifman
Publikováno v:
Cancer Research. 78:5833-5847
Mutations in the tumor suppressor p53 are the most frequent alterations in human cancer. These mutations include p53-inactivating mutations as well as oncogenic gain-of-function (GOF) mutations that endow p53 with capabilities to promote tumor progre
Publikováno v:
Cancer Res
Tight junction (TJ) proteins are essential for mediating interactions between adjacent cells and coordinating cellular and organ responses. Initial investigations into TJ proteins and junctional adhesion molecules (JAM) in cancer suggested a tumor-su
Autor:
Teresa Pirozzi, Tea Teresa Iavazzo, Maria Mangini, Donatella Delle Cave, Annachiara De Luca, Annalisa Di Domenico, Gennaro Andolfi, Enza Lonardo
Publikováno v:
Cancer Research. 81:PO-038
Pancreatic ductal adenocarcinoma (PDAC) is a devastating and essentially incurable disease, typically characterized by high chemoresistance and metastatic spread attributable to cancer stem cells (CSCs). This subpopulation is critical for tumor initi
Publikováno v:
Cancer Research. 77:5158-5168
Obesity is a prognostic risk factor in the progression of prostate cancer; however, the molecular mechanisms involved are unclear. In this study, we provide preclinical proof of concept for the role of a proinflammatory CXCL12–CXCR4/CXCR7 signaling
Autor:
Tait Huso, Karen L. Reddy, Lionel Chia, Jung-Hyun Kim, Leslie Cope, Woo Jung Sung, Shuai Shuai, Ruitao Zhang, Linda M.S. Resar
Publikováno v:
Cancer Research. 81:2414-2414
Pancreatic ductal adenocarcinomas (PDACs) are highly lethal tumors characterized by a dense desmoplastic stroma comprised of cancer associated fibroblasts (CAFs) and fibrotic scar tissue. While stromal CAFs act as a barrier to therapy and release sig
Publikováno v:
Cancer Research. 76:7059-7071
Hepatocellular carcinoma is highly resistant to chemotherapy. Research data supported that cancer stem cells (CSC) may be responsible for the chemoresistance and strategies that suppress CSCs stemness could also inhibit the drug resistance. In this s
Autor:
Tatsunori Nishimura, Noriko Gotoh, Kana Tominaga, Sumio Sugano, Takahiko Murayama, Takashi Kohno, Asuka Nakata, Masato Enari, Arinobu Tojo, Takashi Nakaoku
Publikováno v:
Cancer Research. 76:974-983
The CD74-Neuregulin1 (NRG1) fusion gene was recently identified as novel driver of invasive mucinous adenocarcinoma, a malignant form of lung cancer. However, the function of the CD74-NRG1 fusion gene in adenocarcinoma pathogenesis and the mechanisms
Autor:
Sungpyo Hong, Kwangwoo Hwang, Hyoung Min Cho, Soon Kil Ahn, Min-Hyo Ki, Kug Hwa Lee, Yongbin Park
Publikováno v:
Cancer Research. 80:4212-4212
Triple negative breast cancer (TNBC) is the most aggressive type of breast cancer, classified by a lack of ER and PR, and HER2 overexpression. Attributable to its tumor heterogeneity and a high rate of relapse, TNBC carries poor prognosis accounting
Autor:
Karen L. Reddy, Linda M.S. Resar, Lionel Chia, Leslie Cope, Ruitao Zhang, Shuai Shuai, David L. Huso, Tait Huso, Jung Hyun Kim, Lingling Xian
Publikováno v:
Cancer Research. 80:297-297
Pancreatic ductal adenocarcinomas (PDACs) are highly lethal tumors characterized by a dense desmoplastic stroma comprised of cancer associated fibroblasts (CAFs) and fibrotic scar tissue. While stromal CAFs provide a barrier to therapy and release si