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Publikováno v:
Cancer Research. 76:7059-7071
Hepatocellular carcinoma is highly resistant to chemotherapy. Research data supported that cancer stem cells (CSC) may be responsible for the chemoresistance and strategies that suppress CSCs stemness could also inhibit the drug resistance. In this s
Autor:
Vihren N. Kolev, Sean P. McDermott, Max S. Wicha, Qunli Xu, Jonathan A. Pachter, David T. Weaver
Publikováno v:
Cancer Research. 75:P6-11
Cancer stem cells (CSCs) are an underlying cause of tumor progression and metastasis. In breast cancer, CSCs can be identified by Aldehyde Dehydrogenase 1 (ALDH) or CD44-high/CD24-low expression. Neoadjuvant chemotherapy has been shown to lead to an
Publikováno v:
Cancer Research. 73:P1-07
The retinoblastoma protein (pRB) is a key tumor suppressor that regulates the progression of cell cycles from G1 to S phase. pRB is often inactivated due to mutation, very low level expression or hyperphosphorylation by cyclin-dependent kinases (CDKs
Autor:
Elizabeth Iorns, Dorraya El-Ashry, Joeli Brinkman, Katherine Drews-Elger, Deborah L. Berry, Marc E. Lippman
Publikováno v:
Cancer Research. 72:P1-05
The study of early stage and metastatic breast cancer relies heavily on the use of established cell lines often derived from metastatic lesions rather than from primary tumors, limiting our understanding of primary tumor development. Study of the mec
Autor:
Sharanjot Saini, Rajvir Dahiya, Yuichiro Tanaka, Mohd Saif Zaman, Guoren Deng, Varahram Shahryari, Shahana Majid, Soichiro Yamamura, Sumit Arora, Inik Chang
Publikováno v:
Cancer Research. 72:3618-3630
Tumor recurrence in prostate cancer has been attributed to the presence of CD44-expressing tumor-initiating cells. In this study, we report that miR-708 is a key negative regulator of this CD44+ subpopulation of prostate cancer cells, with important
Autor:
Zuzana Keckesova, Robert A. Weinberg, Evanthia T. Roussos, John S. Condeelis, David Epstein, John D. Haley
Publikováno v:
Cancer Research. 70:7360-7364
Epithelial-mesenchymal transition (EMT) is a developmental program implicated in cancer progression and was the subject of the 2010 AACR meeting on the topic of EMT and Cancer Progression and Treatment held on February 28 to March 2 in Arlington, Vir
Autor:
Robert M. Hoffman, Shan Man, Yuval Shaked, Robert S. Kerbel, Terence Tang, Chris Folkins, Christina R. Lee, Zhenping Zhu
Publikováno v:
Cancer Research. 69:7243-7251
Cancer stem cells (CSC) are predicted to be critical drivers of tumor progression due to their self-renewal capacity and limitless proliferative potential. An emerging area of research suggests that CSC may also support tumor progression by promoting
Autor:
Jane E. Visvader, Mark Shackleton, Geoffrey J. Lindeman, François Vaillant, Marie Liesse Asselin-Labat, Natasha C. Forrest
Publikováno v:
Cancer Research. 68:7711-7717
The cells of origin and mechanisms that underpin tumor heterogeneity in breast cancer are poorly understood. Here, we have examined three mouse models of mammary tumorigenesis (MMTV-wnt-1, MMTV-neu, and p53+/−) for changes in their epithelial cell
Publikováno v:
Cancer Research. 77:1913-1913
Lung cancer is the leading cause of cancer death worldwide in both men and women, every year killing more people than breast, prostate and colon cancers combined. Drug/radiation resistance and tumor relapse contribute to low patient survival, which h
Autor:
Bjørnar Gilje, Oddmund Nordgård, Rune Smaaland, Kjersti Tjensvoll, Morten Lapin, Satu Oltedal, Milind Javle
Publikováno v:
Cancer Research. 77:LB-252
Background: Single-cell analysis of the transcriptional heterogeneity of circulating tumor cells have the prospect of better understanding the biology of these cells and their involvement in the metastatic process. In addition, such analyses may reve