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Autor:
Sharanjot Saini, Rajvir Dahiya, Yuichiro Tanaka, Mohd Saif Zaman, Guoren Deng, Varahram Shahryari, Shahana Majid, Soichiro Yamamura, Sumit Arora, Inik Chang
Publikováno v:
Cancer Research. 72:3618-3630
Tumor recurrence in prostate cancer has been attributed to the presence of CD44-expressing tumor-initiating cells. In this study, we report that miR-708 is a key negative regulator of this CD44+ subpopulation of prostate cancer cells, with important
Autor:
Jane E. Visvader, Mark Shackleton, Geoffrey J. Lindeman, François Vaillant, Marie Liesse Asselin-Labat, Natasha C. Forrest
Publikováno v:
Cancer Research. 68:7711-7717
The cells of origin and mechanisms that underpin tumor heterogeneity in breast cancer are poorly understood. Here, we have examined three mouse models of mammary tumorigenesis (MMTV-wnt-1, MMTV-neu, and p53+/−) for changes in their epithelial cell
Autor:
C Coarfa, M Andreeff, JC Sun, P Nagireddy, Feng Jin, Venkata Lokesh Battula, K Nguyen, B Piyaranthna
Publikováno v:
Cancer Research. 77:P6-02
Breast cancer stem cells (BCSCs) have been characterized as a fraction of cells in primary tumors that are drug resistant and have metastatic potential. Ganglioside GD2 has been shown by us and others as a marker for BCSCs. Furthermore, nutrient depr
Publikováno v:
Cancer Research. 76:2498-2498
Background: Solid malignancies continuously shed tumor cells which may enter the circulation, spread to other tissues and initiate metastases, but it is assumed that only a small subpopulation among CETCs is capable of metastasis formation, the subpo
Publikováno v:
Cancer Research. 75:2320-2320
Colorectal cancer (CRC) initiation and growth is often attributed to stem cells, yet little is known about the regulation of this cell population. We have shown that a subpopulation of cells expressing the Prox1 transcription factor have stem cell ac
Publikováno v:
Cancer Research. 75:1867-1867
Combined hormone replacement therapy (HRT) containing progestins (P) and estrogens (E) has been shown to increase the risk of breast cancer in post-menopausal women (JNCI, 2000, 92:328). We showed that the commonly used P, medroxyprogesterone acetate
Autor:
Rcm. Simmen, T Rogers, Shanmugam Nagarajan, RS Fox, Jmp Pabona, Leah Hennings, Omar M. Rahal, Ying Su
Publikováno v:
Cancer Research. 70:PD02-03
Breast cancer risk is highly modified by environmental factors including diet. Previously, we showed that dietary intake of soy protein isolate (SPI) decreased mammary tumor incidence and increased mammary tumor latency in rats relative to those fed
Publikováno v:
Cancer Research. 71:3331-3331
Introduction: The cancer stem cell (CSC) hypothesis has important clinical implications for cancer therapeutics because of the proposed role of CSCs in chemoresistance. The aim of this study was to investigate changes in the CSC populations before an
Autor:
Tsuyoshi Hasegawa, Masakazu Yashiro, Junko Matsuoka, Shinichiro Kashiwagi, Yuhiko Fuyuhiro, Katsunobu Sakurai, Naoshi Kubo, Hiroaki Tanaka, Kazuya Muguruma, Nobuya Yamada, Kiyoshi Maeda, Masaichi Ohira, Tetsuro Ishikawa, Kosei Hirakawa
Publikováno v:
Cancer Research. 71:5200-5200
Introduction: Cancer stem cells (CSCs) are thought to possess the ability to initiate tumor growth and sustain self-renewal, which explains the tumorigenicity and the maintenance of bulk. There is an increasing evidence of the importance of the host
Autor:
Sarah M. Smith, Charles M. Perou, Lucia J. Chiao, Jerry Usary, Stephen D. Hursting, Lyuba Varticovski, Leticia Nogueria
Publikováno v:
Cancer Research. 71:3332-3332
Epidemiological evidence suggests a potential role of obesity in regulating clinical subtype, differentiation status, and prognosis of breast cancer. Specifically, an elevated waist-hip ratio is associated with increased risk and progression of basal