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Autor:
Hendrik Bläker, Manisha Juneja, Clara Lemos, Boris Jerchow, Wolfram Haider, Ulrike Stein, Markus S. Hardt, Cynthia Voss, Susann Förster
Publikováno v:
Cancer Research. 76:2689-2689
We have previously identified the gene Metastasis-Associated in Colon Cancer 1 (MACC1). MACC1 acts a strong prognostic biomarker for colorectal cancer metastasis and patient survival. Meanwhile, MACC1 has been established as a biomarker for tumor pro
Publikováno v:
Cancer Research. 75:2320-2320
Colorectal cancer (CRC) initiation and growth is often attributed to stem cells, yet little is known about the regulation of this cell population. We have shown that a subpopulation of cells expressing the Prox1 transcription factor have stem cell ac
Publikováno v:
Cancer Research. 74:3868-3868
The overexpression of Six1, a member of the Six family of homeodomain transcription factors, has been found in various human cancers, and is associated with increased tumor progression and metastasis. Previous studies in our laboratory discovered tha
Autor:
Silvio Daester, Valentina Mele, Paul Zajac, Nunzia Amatruda, Giandomenica Iezzi, Giulio C. Spagnoli, Diego Calabrese, Manuele G. Muraro
Publikováno v:
Cancer Research. 73:3834-3834
Objective: Multicellular tumor spheroid is a well-known method for three-dimensional in-vitro culture that better represent in-vivo condition. We exploited this system to culture human established colorectal cell lines to investigate how the presence
Autor:
Graça Almeida-Porada, Evan Colletti, Christine A. Iacobuzio-Donahue, Linda M.S. Resar, David L. Huso, Amy M. Belton
Publikováno v:
Cancer Research. 71:931-931
The molecular mechanisms that enable colon cancer cells to evade therapy and metastasize are poorly understood and have not been effectively targeted by current therapies. Recent evidence suggests that tumor cells with stem-like properties (poor diff
Autor:
Gabriel Capellá, Purificación Muñoz, Alberto Villanueva, Ramon Salazar, Diana Riba-Artés, Victoria da Silva-Diz, Maria Urpí, Mireia Gausachs
Publikováno v:
Cancer Research. 70:3337-3337
Current chemotherapy for colorectal cancer is still based in combined 5-fluorouracil (5-FU) and oxaliplatin administration with or without other new drugs. However, an important percentage of patients show resistance to this treatment. Tumor initiati