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Autor:
Elizabeth E. Hull, Brianna Flores
Publikováno v:
Cancer Research. 78:556-556
The tumor suppressor p53 protein is mutated in over 50% of cancers. The most frequent mutations in p53, termed “hotspot” mutations, occur in the DNA binding domain of the p53 protein. These mutations not only remove normal p53 function but also c
Autor:
Matti Nykter, Elisa M. Vuorinen, Anne Kallioniemi, Nina Rajala, Anastasia Shcherban, Alejandra Martinez
Publikováno v:
Cancer Research. 78:3353-3353
Background: The Zinc Finger Protein 414 (ZNF414) is a member of the krüppel C2H2-type zinc-finger protein family. ZNF414 is a cargo protein for Karyopherin α7 (KPNA7), a nuclear importer expressed during embryogenesis, absent in most adult tissues