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Autor:
Tobias Xiao Dong, Rui Xie, Jingyu Xu, Hanxing Wan, Hui Dong, John M. Carethers, Ya-Han Fan, Jilin Wu, Bo Tang, Michael X. Zhu, Yu-Yun Wu, Jingjing Liu, Shi-Ming Yang, Suming Wang, Yu-Feng Xiao
Publikováno v:
Cancer Research. 77:6499-6512
Although dietary calcium intake has long been recommended for disease prevention, the influence of calcium in development of cancer in the upper gastrointestinal tract has not been explored. Here, we assess the roles of calcium and calcium-sensing re
Autor:
Ling Cen, Sweta Dash, Andrew Smith, Sean Yoder, Chaomei Zhang, Tania Mesa, Guillermo N. Armaiz-Pena, Alvaro N.A. Monteiro, Jamie K. Teer
Publikováno v:
Cancer Research. 81:736-736
Chronic stress induced by repetitive activation of the sympathetic nervous system leads to rapid release of catecholamines like norepinephrine (NE). Several studies have shown that increased levels of NE can contribute to tumor progression by promoti
Autor:
Jessica Liu, Paul Frankel, Marice Alcantara, Przemyslaw Twardowski, Marcin Kortylewski, Tanya B. Dorff, S.V. Dandapani
Publikováno v:
Cancer Research. 81:677-677
Prostate cancer is the second leading cause of death in men in the developed countries. Androgen deprivation therapy (ADT) is commonly used to treat prostate tumors at earlier stages due to hormone-dependence of cancer cells. However, the onset of an
Autor:
Hernan G. Farina, Johanna E. Sidabra, Carla S. Capobianco, Maria F. Gottardo, Julio A. Aguirre Ghiso, Daniel F. Alonso
Publikováno v:
Cancer Research. 80:5983-5983
The p38 pathway can be activated by three different MAP kinase kinases: MKK3, MKK4 and MKK6, each one activated by different stimuli, like DNA damage, oxidative stress, proinflammatory cytokines or growth factors. In consequence, the responses mediat
Autor:
QT Bui, Keon Wook Kang
Publikováno v:
Cancer Research. 76:P1-05
Epithelial-mesenchymal transition (EMT) is process in which epithelial cells undergo unique morphologic changes characterized by a transition from epithelial cobblestone phenotype to elongated fibroblastic phenotype (mesenchymal phenotype) leading to
Publikováno v:
Cancer Research. 76:P1-16
Clinical trials and epidemiological evidence show that combined estrogen (E) and progestin (P) hormone replacement therapy (HRT) increases the risk of breast cancer in postmenopausal women, whereas HRT containing E alone does not. Tumor progression i
Autor:
Nicole M. Kettner, Tuyen Bui, Debu Tripathy, Kelly K. Hunt, Funda Meric-Bernstam, David J. Tweardy, T. Kris Eckols, Min Jin Ha, Khandan Keyomarsi
Publikováno v:
Cancer Research. 80:P6-04
Background: CDK4/6 inhibitors (i.e. palbociclib) in combination with endocrine therapy (ET) are currently standard of care for estrogen receptor (ER) positive breast cancer patients with advanced/metastatic disease. While this combination has proven
Autor:
Qiu Wang, Jasper H. L. Claessen, Ethan S. Sokol, Sandhya Sanduja, Piyush Gupta, Theresa A. Proia, Yuxiong Feng, Ferenc Reinhardt, Hidde L. Ploegh, Dexter X. Jin, Catherine A. Del Vecchio
Publikováno v:
Cancer Research. 75:P2-07
Epithelial-to-mesenchymal transition (EMT) plays an important role in cancer progression. By undergoing an EMT, cancer cells acquire a spectrum of malignant properties, including invasiveness, multi-drug resistance and stem-like traits. Although they
Autor:
Sergey Klimov, Guilherme Cantuaria, Ritu Aneja, Karuna Mittal, Padmashree C.G. Rida, Michelle D. Reid, Vaishali Pannu
Publikováno v:
Cancer Research. 75:P5-10
Breast tumors harbor extensive intratumoral heterogeneity (ITH), both within primary and metastatic lesions. The generation of this genetic diversity relies on chromosomal instability (CIN), a dynamic and complex multilayered phenotype. CIN comprises
Autor:
Phillip Jobling, Sónia M R Oliveira, Hubert Hondermarck, Jay Pundavela, Marjorie M. Walker, Séverine Roselli
Publikováno v:
Cancer Research. 75:1777-1781
Recent studies have revealed the essential role played by nerves in tumor progression. Nerves have been shown to infiltrate the tumor microenvironment and actively stimulate cancer cell growth and dissemination. This mechanism involves the release of