Zobrazeno 1 - 10
of 20
pro vyhledávání: ''
Publikováno v:
Cancer Research. 64:6950-6956
The interactions between cancer cells and surrounding stroma play a critical role in tumor progression, but their molecular basis is largely unknown. Global gene expression profiling was performed using oligonucleotide microarrays to determine change
Publikováno v:
Cancer Research. 77:LB-327
Pancreatic ductal adenocarcinoma (PDAC) still remains to be one of the most highly malignant human diseases and is resistant to the majority of current therapeutic modalities. Oncogene MYC has been known to be upregulated in PDAC and plays a key role
Autor:
Michael S. Samuel, Ilse Rooman, Ewan J. McGhee, Michael F. Olson, Lena Helbig, Alexei Vazquez, Jennifer P. Morton, Shereen Kadir, Gabriela Kalna, Andreia V. Pinho, Kurt I. Anderson, Linda Julian, Nicola Rath
Publikováno v:
Cancer Research. 76:C22-C22
Pancreatic cancer is one of the leading causes of cancer death and despite advances in chemotherapeutic regimens the overall 5-year survival rate remains less than 5%. The actomyosin-regulating ROCK1 and ROCK2 kinases are downstream-targets of the Rh
Autor:
Douglas Hanahan, Iacovos P. Michael
Publikováno v:
Cancer Research. 76:1907-1907
MicroRNAs (miRs) are implicated in the pathogenesis of various malignancies, including pancreatic cancer, and may represent key players in the metastatic process. In a previous study (Olson et al., 2009), we identified two unique miR signatures assoc
Publikováno v:
Cancer Research. 76:4577-4577
The fibroblast growth factor receptor (FGFR) family plays crucial roles in development, tissue repair, and malignant tumors. FGFR-1, -2, and -3 each exist in two isoforms, IIIb and IIIc, due to alternative splicing of the extracellular domain, wherea
Autor:
Todd Moore, Baoan Ji, Vijaya Ramachandran, Keith D. Amos, Thiruvengadam Arumugam, Douglas B. Evans, Rosa F. Hwang, Armando Rivera, Craig D. Logsdon
Publikováno v:
Cancer research. 68(3)
Pancreatic adenocarcinoma is characterized by a dense background of tumor associated stroma originating from abundant pancreatic stellate cells. The aim of this study was to determine the effect of human pancreatic stellate cells (HPSC) on pancreatic
Autor:
Fuyuki Sato, Yasuteru Muragaki
Publikováno v:
Cancer Research. 75:2999-2999
Circadian rhythms are tightly regulated by clock genes. It has been reported that clock genes plays important roles in biological function of normal cells. However, it is not well understood the function of clock genes in tumor cells. We showed that
Autor:
Mark Wade, Ronald M. Evans, Miranda L. Cox, Maya Ridinger, Michael Downes, Christopher Liddle, Geoffrey M. Wahl, Annabelle Kraus
Publikováno v:
Cancer Research. 75:B10-B10
Pancreatic ductal adenocarninoma (PDA) is one of the most aggressive human cancers and is characterized by a predominant stromal compartment mainly composed of fibroblastic and immune cells. Pancreatic stellate cells (PSCs) are the main fibroblastic
Publikováno v:
Cancer Research. 75:A43-A43
A characteristic feature of pancreatic cancer is the predominant stroma, which consists of fibroblasts, immune cells and a significant deposition of extracellular matrix (ECM). The stroma accounts for over eighty percent of the pancreatic tumor mass
Autor:
Bhavin Chauhan, Fathi T. Halaweish, Mohammed Sikander, Meena Jaggi, Sheema Khan, Murali M. Yallapu, Mohd Saif Zaman, Subhash C. Chauhan, Neeraj Chauhan
Publikováno v:
Cancer Research. 74:2714-2714
Background: Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer-related death in United States. Tremendous efforts have witnessed the failure of many chemotherapeutic regimens and the current standard-of-care therapy, gemcit