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Publikováno v:
Cancer Research. 73:P1-07
The retinoblastoma protein (pRB) is a key tumor suppressor that regulates the progression of cell cycles from G1 to S phase. pRB is often inactivated due to mutation, very low level expression or hyperphosphorylation by cyclin-dependent kinases (CDKs
Autor:
Tony Navas, Brad A. Gouker, Susan Holbeck, Apurva K. Srivastava, Angelena Millione, Suzanne Borgel, Alice P. Chen, Donna Butcher, James H. Doroshow, Robert J. Kinders, Shivaani Kumar, Ralph E. Parchment, Melinda G. Hollingshead, Donald P. Bottaro, John Carter
Publikováno v:
Cancer Research. 77:845-845
Epithelial-mesenchymal transition (EMT) is a critical process implicated in metastasis. Despite extensive research, the clinical significance of EMT remains unclear, and a quantitative evaluation of this process in human tumors has yet to be demonstr
Autor:
KC Scribner, Ww. Porter
Publikováno v:
Cancer Research. 70:P4-06
Despite advances in breast cancer treatment and prevention, metastasis remains the primary cause of breast cancer mortality. In addition to the acquisition of cellular processes in tumors that promote growth and invasion, the differentiation status o
Autor:
Esta Sterneck, Philip J. Tofilon, Shikha Sharan, Kuppusamy Balamurugan, Daniel Mendoza-Villanueva, Barbara H. Rath
Publikováno v:
Cancer Research. 76:2017-2017
The transcription factor C/EBPdelta (CEBPD) is expressed in normal mammary epithelial cells and high expression in breast cancer correlates with hormone receptors and good prognosis (Mendoza-Villanueva et al., submitted). In the MMTV-Neu mouse model,
Publikováno v:
Cancer Research. 76:4107-4107
Cluster of differentiation 44 (CD44) has been identified as a cancer stem cell marker in breast [1], pancreatic, prostate, ovarian, and colon cancer [2] making it a significantly important molecule for investigating and targeting. CD44 is abundant in
Publikováno v:
Cancer Research. 75:1867-1867
Combined hormone replacement therapy (HRT) containing progestins (P) and estrogens (E) has been shown to increase the risk of breast cancer in post-menopausal women (JNCI, 2000, 92:328). We showed that the commonly used P, medroxyprogesterone acetate
Autor:
Bedrich L. Eckhardt, Naoto T. Ueno, Hideyuki Saya, Chad J. Creighton, Kazuharu Kai, Yuan Qi, Debu Tripathy
Publikováno v:
Cancer Research. 75:1078-1078
Background: Tumor Growth Factor-β (TGF-β) and Tumor Necrosis Factor-α (TNF-α) are cytokines, which induce the local inflammation and contribute to tumor invasion and metastasis. Recent reports show that TGF-β and TNF-α induce epithelial-to-mese
Publikováno v:
Cancer Research. 75:1421-1421
Breast cancer metastases are caused by extravasation of cancer cells from the primary tumor; once released, the cells travel through the circulation and initiate secondary tumors at distant sites. However, it is not clear how these metastasizing mese
Autor:
Gareth I. Owen, Sumie Kato, Olga Panes, Renan Orellana, Loreto Bravo, Pamela Gonzalez, Barbara Oliva, Diego Mezzano, Mauricio Cuello
Publikováno v:
Cancer Research. 74:1117-1117
Introduction: An increase in circulating platelets, or thrombocytosis, is recognized as an independent risk factor correlated with bad prognosis and metastasis, however the exact role that platelets play in tumor progression has not been fully elucid
Autor:
Yuichiro Tanaka, Shinji Tanaka, Ryo Yuge, Yasuhiko Kitadai, Wataru Yasui, Mieko Onoyama, Kei Shinagawa, Kazuaki Chayama
Publikováno v:
Cancer Research. 74:180-180
Bone marrow-derived mesenchymal stem cells (MSCs) have been reported to contribute to the formation of tumor stroma. We reported recently that in an orthotopic nude mouse model of human colon cancer, MSCs migrated to tumor stroma, where they differen