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Publikováno v:
Cancer Research. 81:PS6-46
Background Breast cancer is the second most common cancer in the world and most frequent among women. Tumor-infiltrating lymphocytes (TILs) can impact tumor progression and response to therapies. Here we aimed to study TILS using the International Im
Autor:
Ajeeth K. Pingili, Jared C Clements, Joseph F. Pierre, Mehdi Chaib, Neena A John, Emily B. Korba, Mary C Lovely, Laura M. Sipe, Liza Makowski
Publikováno v:
Cancer Research. 81:PS17-29
Background: Obesity leads to a higher risk of cancer invasion, metastases, recurrence, mortality, and impaired therapeutic response through various mechanisms. One of these mechanisms is microenvironment dysfunction, where changes in immune cells, mi
Autor:
Anwesha Chaudhury, Nuria Chic, Tetiana Taran, D. Martinez, Nadia Solovieff, Karen Rodriguez-Lorenc, Fara Brasó-Maristany, Aleix Prat, Faye Su, Laia Paré, Olga Martínez, Naveen Babbar
Publikováno v:
Cancer Research. 81:GS1-04
Background: The prognostic and predictive value of the 4 main intrinsic subtypes of breast cancer (ie, luminal A [LumA], luminal B [LumB], human epidermal growth factor receptor 2 enriched [HER2E], and basal-like) in hormone receptor-positive, HER2
Autor:
Richard A. Larson, Rong Ye, Savitri Krishnamurthy, Shane R. Stecklein, Renae Van Whye, Randa El-Zein, Wendy A. Woodward, Jing Ning, Omar M. Rahal, Wintana Balema
Publikováno v:
Cancer Research. 80:P6-15
Introduction/Motivation: We previously reported IBC patients with limited breast-feeding history have a worse prognosis than those with greater breast feeding history. Further, we reported pregnancy related factors including multiple early pregnancie
Autor:
Chun Wang, Frederick M. Fellin, Darayus Toorkey, Kaelan Yao, Neha Pancholy, Saveri Bhattacharya, Maysa M. Abu-Khalaf, Ronald E. Myers, Rebecca Jaslow, Daniel P. Silver, Zhong Ye, AnaMaria Lopez, Hushan Yang, Zhenchao Zhang
Publikováno v:
Cancer Research. 80:P6-10
Background: Circulating tumor cells (CTCs) and their clusters (CTC-clusters) are promising prognostic markers in breast cancer. Recently studies showed that platelets interact with tumor cells in the circulation and promote metastasis. However, no st
Autor:
Helen Piwnica-Worms, Cullen M. Taniguchi, Anirban Maitra, Sonal Gupta, Meifang Yu, Amit Deorukhkar, Marimar de la Cruz Bonilla, Yanqing Huang, Charles V. Kingsley, Laura Baseler, Daniel Lin, Lauren E. Colbert, Eugene J. Koay, Tara N. Fujimoto, Gabriel O. Sawakuchi, Jessica M. Molkentine, Peter K. Cabeceiras, Ramesh C. Tailor
Publikováno v:
Cancer Res
When pancreatic cancer cannot be removed surgically, patients frequently experience morbidity and death from progression of their primary tumor. Radiation therapy (RT) cannot yet substitute for an operation because radiation causes fatal bleeding and
Autor:
G-U Woo, Wonshik Han, H-G Moon, M-S Jin, K-H Lee, D. Lee, Koung Jin Suh, Hj. Kim, Ia Park, T-Y Kim, H-B Lee, HS Ryu, D-Y Noh, Yil Suk Yang, S-A Im
Publikováno v:
Cancer Research. 79:P2-07
Background: Immune cells in the tumor microenvironment play an essential role in tumor progression and regression. However, immunologic characteristics and their prognostic role have not been clearly identified in breast cancer patients. This study a
Autor:
Francois Richard, M.J. Piccart, G Rouas, D. Larsimont, Diether Lambrechts, David R. Brown, Giancarlo Pruneri, Florian Clatot, S Majjaj, Bram Boeckx, C Desmedt, G. Van den Eynden, Caterina Marchiò, Françoise Rothé, Anne Vincent-Salomon, Odette Mariani, Christos Sotiriou, Christine Galant, Julien Pingitore, François Bertucci, Roberto Salgado
Publikováno v:
Cancer Research. 79:GS1-06
Background: Invasive lobular breast cancer (ILC) represents the second most common histology of breast cancer, accounts for 10-15% of all invasive cases and generally expresses the estrogen receptor (ER, coded by the ESR1 gene). Little is known about
Autor:
A-M Larsson, Kristina Aaltonen, Sara Jansson, Lisa Rydén, P-O Bendahl, Sharyn D. Baker, Michael Bergqvist
Publikováno v:
Cancer Research. 78:P3-08
Introduction: Although prognosis and treatment of metastatic breast cancer (MBC) have improved over the last years, there is still an unmet clinical need for more precise prognostic and treatment monitoring tools. Liquid-based markers are preferred s
Autor:
Tessa Cigler, Naomi Kornhauser, Vivek Mittal, Alysia Wiener, Amy D. Willis, Maureen M. Ward, Linda T. Vahdat, JD Warren, Anne Moore, Veronica Fitzpatrick, Anna Rubinchik, S Sahota, M Cobham, D Ko, A De Laurentiis, N Prima, Sarah E. Schneider, Eleni Andreopoulou
Publikováno v:
Cancer Research. 78:P1-10
Background: Metals have emerged as a viable therapeutic target for a new generation of anti-cancer and anti-metastatic agents. Copper, an essential trace element, serves as an important catalytic cofactor in several biological functions and has emerg