Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Irene M. Ghobrial"'
Autor:
Daisy Huynh, Benjamin L. Ebert, Paul G. Richardson, Irene M. Ghobrial, Jerome Ritz, Kenneth C. Anderson, Mark Bustoros, Saud H. AlDubayan, Nikhil C. Munshi, Christopher J. Gibson, Donna Neuberg, Chia-Jen Lui, Brendan Reardon, Jacob P. Laubach, Robert L. Schlossman, Jihye Park, Amin Nassar, Salomon Manier, David P. Steensma, Tarek H. Mouhieddine, Kalvis Hornburg, Marzia Capelletti, Robert J. Soiffer, Henry Dumke, Romanos Sklavenitits Pistofidis, Darlys Schott, Cody J. Boehner, Eliezer M. Van Allen, Robert A. Redd
Publikováno v:
Cancer Research. 78:2954-2954
Introduction: Multiple Myeloma (MM) is a clonal plasma cell malignancy, accounting for 10% of all hematological malignancies. Genetic analyses of large populations revealed that blood-specific somatic mutations in hematopoietic stem cells (HSCs) are
Autor:
Hai Ngo, Mona F. Melhem, Alexey A. Leontovich, Morie A. Gertz, Rafael Fonseca, Yazan Alsayed, Steven P. Treon, Diane George, Evdoxia Hatjiharissi, Irene M. Ghobrial, Kenneth C. Anderson, Michael Timm, Xavier Leleu, Xiaoying Jia, Anne Moreau, Steven C. Zeismer, Thomas E. Witzig, Ganwei Lu, Miguel E. Cabanela, Alex Nehme, Joanna M. Ghobrial
Publikováno v:
Cancer research. 67(8)
To better understand the molecular changes that occur in Waldenstrom macroglobulinemia (WM), we employed antibody-based protein microarrays to compare patterns of protein expression between untreated WM and normal bone marrow controls. Protein expres
Autor:
Fabio Facchetti, Irene M. Ghobrial, Yuji Mishima, Michele Moschetta, Aldo M. Roccaro, Anna Kruschinski, Antonio Sacco, Giuseppe Rossi, Yosra Aljawai, Patricia Maiso
Publikováno v:
Cancer Research. 75:PR14-PR14
Background. Multiple myeloma (MM) patients present with multiple lytic lesions at diagnosis, indicating the presence of continuous dissemination of MM cells from the primary site of tumor development to multiple distant bone marrow (BM) niches. We hy
Autor:
Antonio Sacco, John M. Asara, Richard O. Hynes, Aldo M. Roccaro, Alberto Rocci, Alexandra Naba, Irene M. Ghobrial, Manuela Gambella, Antonio Palumbo, Siobhan Glavey
Publikováno v:
Cancer Research. 74:4855-4855
Background: The extracellular matrix is a major component of the tumor microenvironment, contributing to the regulation of cell survival, proliferation, differentiation and metastasis. In multiple myeloma (MM) ECM components, such as integrins, fibro
Autor:
William Senapedis, Chirag Acharya, Yu-Tzu Tai, Irene M. Ghobrial, Michele Cea, Yosef Landesman, Jean-Richard Saint-Martin, Paul G. Richardson, Yolanda Calle, Lizi Wu, Michael Kauffman, Aditya Munshi, Nikhil C. Munshi, Daniel Tannenbaum, Steve Schey, Sharon Shacham, Mike Zhong, Antonia Cagnetta, Kenneth C. Anderson, Haoqiang Ying, Trinayan Kashyap, Andrew L. Kung, Michaela R. Reagan, Yumei Gu
Publikováno v:
Cancer Research. 73:2142-2142
The key nuclear export protein CRM1 (chromosomal region maintenance 1, Exportin 1, XPO1) may directly contribute to the pathophysiology of human multiple myeloma (MM). Here, we characterized the role of CRM1 in MM biology and defined the efficacy and
Autor:
Adriana Zingone, Ryan Plyler, Irene M. Ghobrial, Neha Korde, Aldo M. Roccaro, Ola Landgren, Weixin Wang, Katherine R. Calvo
Publikováno v:
Cancer Research. 71:802-802
Cytokines serve vital roles in the regulation of immune responses. In patients diagnosed with hematologic malignancies, cytokines may play a role in the tumor-host microenvironment affecting tumor survival and progression. Previous studies have quant