Zobrazeno 31 - 40
of 918
pro vyhledávání: '"33"'
Autor:
Zev A. Wainberg, Yoon Koo Kang, Raquel Guardeno Sanchez, Steven Smith, Derek Murphy, Siddhartha Mitra, Allie Tappe, Michelle Y. Sun, Peter C. Enzinger, Aaron Q. Xu, Ian Misner, Giovanni Gerardo Cardellino, Daniel V.T. Catenacci
Publikováno v:
Cancer Research. 81:2187-2187
Background: Metastatic GEA is a molecularly heterogeneous disease with limited therapeutic options. It is the third most common cause of cancer death globally. Targeted therapies against HER2 positive and microsatellite instability-high (MSI-H) GEA h
Autor:
Marina Celanovic, Mario Campone, Alice Gosselin, Sarat Chandarlapaty, Aditya Bardia, Séverine Doroumian, Hannah M. Linden, Vasiliki Pelekanou, Gary A. Ulaner
Publikováno v:
Cancer Research. 81:PD8-08
Background SERDs belong to a class of ER-targeted therapies that antagonize and degrade ERs, including in ER-dependent tumors resistant to other endocrine therapies (ET). This study (AMEERA-1; NCT03284957) investigates SAR439859, an oral SERD, as mon
Autor:
Luigi Marcheselli, Elisabetta De Matteis, Andrea Michelotti, Sergio Rizzo, Andrea Rocca, Antonino Musolino, Marta Venturelli, Alberto Zambelli, Federica Caggia, Annita Gozzi, Elena Fiorio, Valentina Arcangeli, Giancarlo Bisagni, Valentina Guarneri, Laura Cortesi
Publikováno v:
Cancer Research. 81:OT-31
Background Considering the high proportion of tumor-infiltrating lymphocytes (TILs) in BRCA-related breast cancer, we expect that PD-1 pathway is highly expressed and PD-1 antagonist pembrolizumab could provide clinical activity in this kind of tumor
Autor:
Rosalind P. Candelaria, Beatriz E. Adrada, Mediget Teshome, Elsa Arribas, M Chavez Mac-Gregor, Benjamin Smith, Wei Tse Yang, Gaiane M. Rauch, Sarah M. DeSnyder, Michael Z. Gilcrease, V. Valero, Savitri Krishnamurthy, Anthony Lucci, Brian P. Hobbs, Lumarie Santiago, Henry Mark Kuerer, Abigail S. Caudle, Makesha V. Miggins, Tanya W. Moseley, Rosa F. Hwang, K. K. Hunt
Publikováno v:
Cancer Research. 77:P5-16
Background: Contemporary improved neoadjuvant systemic therapy (NST) for breast cancer may result in a pathologic complete response (pCR) in up to 60% of patients (pts) yet imaging alone has a poor negative predictive value to determine which pts mig
Autor:
William Jacot, Mary C. Schroeder, Alexandra Thomas, Sarah L. Mott, Rachna Raman, Marie Viala, S Pouderoux, P-J Lamy, S. Thezenas
Publikováno v:
Cancer Research. 77:P6-09
Introduction: Pathologic complete response (pCR) following neoadjuvant systemic chemotherapy (NAC) serves as a measure of tumor responsiveness and is a recognized surrogate for improved long-term outcomes. Some, but not all, studies have found a posi
Autor:
Neil Mitra, Hiromichi Miyagaki, Xiaohong Yan, Chandana Herath Mudiyanselage, Dasuni Niyagama Gamage, Richard L. Whelan, Abhinit Shah, Vesna Cekic
Publikováno v:
Cancer Research. 80:3138-3138
Introduction: Platelet-derived growth factor-DD (PDGF-DD), a member of the PDGF family, is secreted as a latent homodimer which is activated by uPA (urokinase). After binding to its receptor, PDGF Rβ, PDGF-DD plays a role in mesenchymal transition,
Autor:
Gilberto de Castro, J. Kobie, Kazuo Kasahara, Bilal Piperdi, Andrey Loboda, Byoung Chul Cho, Tony Mok, M. Catherine Pietanza, Jared Lunceford, Gilberto Lopes, Yi-Long Wu, Mark Ayers, Deepti Aurora-Garg, Dariusz M. Kowalski, Hande Turna, Razvan Cristescu
Publikováno v:
Cancer Research. 80:CT084-CT084
Background: STK11 (also known as LKB1) and KEAP1 mutations have been associated with chemoresistance and poor outcomes and shown to be more frequent in PD-L1-negative tumors with high tumor mutational burden (TMB). We performed an exploratory analysi
Autor:
Dongling Gao, Nan Dong, Yuchen Han, Ruiying Zhao, Xue Wu, Zhihua Zhao, Qiuxiang Ou, Wencai Li, Guozhong Jiang, Xiaoling Tong
Publikováno v:
Cancer Research. 80:741-741
Background ROS1 gene rearrangements are reported at a prevalence of 1-2% in unselected cancer populations including non-small cell lung cancer (NSCLC), and notably higher in lung adenocarcinoma. More than twenty ROS1 fusion partners have been identif
Publikováno v:
Cancer Research. 80:5761-5761
Background: The risk factors of female lung cancer in China are still unclear. The growing trend of lung cancer in Chinese women has become a global concern of public health. This study aims to explore the secular trends and regional distribution of
Autor:
Michael Rossi, Johanna C. Bendell, Susanna Varkey Ulahannan, Amit Mahipal, Andrea Cercek, Daniel Brickman, Katrina S. Pedersen, Abraham Fong
Publikováno v:
Cancer Research. 80:CT167-CT167
Background: Colorectal cancer (CRC) is the third most common cancer in the United States. Aberrant activation of the Wnt signaling pathway is associated with CRC progression. Ring finger protein 43 (RNF43) is a single-pass type 1 transmembrane protei