Zobrazeno 1 - 7
of 7
pro vyhledávání: '"929"'
Autor:
Jinsuk Kang
Publikováno v:
Cancer Research. 81:929-929
STAT3 functions are largely bifurcated: (1) STAT3 activated by Y705 phosphorylation (pY705) regulates target-gene expression in nucleus. (2) STAT3 activated by S727 phosphorylation (pS727) supports a electron transport complex (ETC) in mitochondria.
Autor:
Max S. Wicha, Michael D. Brooks
Publikováno v:
Cancer Research. 77:929-929
The CSC hypothesis posits that there is a subset of tumors cells driving tumor growth and metastasis and that by targeting this population, tumors can be more efficiently eradicated. Recently it was shown that there are two types of CSCs in breast ca
Autor:
Noopur Shah, Fang Liu, Hubert Maehr, Amanda K. Smolarek, Milan R. Uskokovic, Jae Young So, Nanjoo Suh
Publikováno v:
Cancer Research. 72:929-929
CD44, a transmembrane glycoprotein, is highly expressed in breast tumors, and the overexpression of CD44 has been associated with poor clinical outcome. CD44 has been known to play a key role in invasive growth of cancer by interacting with extracell
Autor:
Bradley M. Turner, Danielle E. Desa, Edward B. Brown, Brandon Buscaglia, Robert L. Strawderman, Robert L. Hill, David G. Hicks
Publikováno v:
Cancer Research. 79:P6-09
Background: Over-expression of Human Epidermal Growth Factor receptor-2 (HER2) in breast cancer is associated with an aggressive clinical course and poor prognosis. Targeting HER2 over-expression has been shown to be a remarkably effective therapeuti
Publikováno v:
Cancer Research. 79:P1-10
Background: Type II diabetes (T2D) has been found to modestly (10-20%) increase risk for breast cancer (BC) in mostly white populations. Some studies indicate that this association varies by BC receptor subtype, suggesting that T2D increases risk spe
Autor:
Romualdo Barroso-Sousa, Priti Kumari, Andrew D. Cherniack, Alice H. Berger, Deborah A. Dillon, Ethan Cerami, EP Winer, Ian E. Krop, Neal I. Lindeman, N Wagle, Ana C. Garrido-Castro, Melissa E. Hughes, Brittany L. Bychkovsky, S Di Lascio, H Guo, Nu Lin, Laura E. MacConaill, Janet Files, Elizabeth A. Mittendorf
Publikováno v:
Cancer Research. 79:PD9-01
Background: Discordance in hormone receptor (HR) status between primary (p) tumors and metastatic (m) recurrences has been widely described. Loss of estrogen and progesterone receptor expression occurs in ˜12% of asynchronous recurrences, leading to
Publikováno v:
Cancer Research. 69:4105
Abstract #4105 Introduction: The decision to treat women with hormone receptor-positive breast cancer with chemotherapy in addition to hormonal therapy is complex. Models have been developed to assist physicians in estimating survival benefit associa