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Autor:
Finn Cilius Nielsen, Olga Oestrup, Ulrik Lassen, Hans Skovgaard Poulsen, Petra Hamerlik, Jane Skjøth-Rasmussen, Christina Westmose Yde, Dorte Schou Noeroexe
Publikováno v:
Cancer Research. 81:444-444
Introduction: Glioblastoma (GBM) is a heterogenous cancer with a high degree of intratumoral subclonality. We foresee that future treatment will be a combination of non-targeted and targeted therapies against molecular features of each patient. In or
Autor:
Nancy Tray, Karen Hiotis, Deborah Axelrod, Victor Ty, Judith D. Goldberg, Farbod Darvishian, Maryann Kwa, Yelena Novik, Sylvia Adams, Amber A. Guth, James L. Speyer, Adriana Heguy, Douglas K. Marks
Publikováno v:
Cancer Research. 80:OT1-01
BACKGROUND: Receptor activator of NF-kB (RANK) and its ligand (RANKL) have a well-established role in osteoclast-driven bone remodeling, however RANK/RANKL expression can also be seen on mammary epithelial cells and immune cells (IC). In breast cance
Autor:
Renjie Jin, Robert J. Matusik, Tatsuki Koyama, Joseph A. Smith, Peter E. Clark, Yajun Yi, Fiona E. Yull, Timothy S. Blackwell
Publikováno v:
Cancer Research. 74:2763-2772
In many patients with prostate cancer, the cancer will be recurrent and eventually progress to lethal metastatic disease after primary treatment, such as surgery or radiation therapy. Therefore, it would be beneficial to better predict which patients
Autor:
Salvatore Panza, Stefania Catalano, Ines Barone, Gianluca Bossi, Stefania Marsico, Daniela Bonofiglio, Sebastiano Andò, Kyle R. Covington, Suzanne A. W. Fuqua, Luca Gelsomino, Cinzia Giordano
Publikováno v:
Cancer Research. 72:1416-1427
Obesity confers risks to cancer development and progression but the mechanisms underlying these risks remain unclear. In this study, we identify a role for the obesity cytokine leptin, which has been implicated previously in breast cancer development
Autor:
Takuya Murata, Tadashi Kimura, Kiyoshi Yoshino, Ichino Chinen, Hiroki Moribe, Yutaka Ueda, Hiroto Mizushima, Robert M. Hoffman, Shigeo Yagi, Eisuke Mekada, Takayuki Enomoto
Publikováno v:
Cancer Research. 71:6633-6642
Tumor stroma drives the growth and progression of cancers. A heparin-binding epidermal growth factor–like growth factor, HB-EGF, is an EGF receptor ligand that stimulates cell growth in an autocrine or paracrine fashion. While elevated expression o
Loss of E-Cadherin Promotes Ovarian Cancer Metastasis via α5-Integrin, which Is a Therapeutic Target
Autor:
S. Diane Yamada, Vinay Bhaskar, A. Reza Radjabi, Amy R. Becker, Ernst Lengyel, Emily O. Kistner, Marcus E. Peter, Hilary A. Kenny, Sujatha Jagadeeswaran, Kenjiro Sawada, Anthony G. Montag, Anirban K. Mitra, Vanitha Ramakrishnan, Maria Tretiakova
Publikováno v:
Cancer Research. 68:2329-2339
E-cadherin loss is frequently associated with ovarian cancer metastasis. Given that adhesion to the abdominal peritoneum is the first step in ovarian cancer dissemination, we reasoned that down-regulation of E-cadherin would affect expression of cell
Autor:
Yoshiki Murakumo, Maki Ishida, Naoya Asai, Masahide Takahashi, Takuya Kato, Mayumi Jijiwa, Tomoko Sato, Taisaku Hasegawa, Ping Jiang, Atsushi Enomoto
Publikováno v:
Cancer Research. 68:1310-1318
Girdin (girders of actin filaments) is a novel actin-binding Akt substrate that plays an important role in actin organization and Akt-dependent cell motility in fibroblasts. Here, we find that Girdin is expressed in a variety of cancer cell lines, in
Publikováno v:
Cancer Research. 67:8486-8493
Heparin-binding epidermal growth factor-like growth factor (HB-EGF) is a member of the EGF growth factor family. Initially synthesized as a membrane-bound precursor (pro-HB-EGF), it is cleaved at the juxtamembrane domain to release the soluble form o
Publikováno v:
Cancer Research. 66:9705-9713
Inhibition of prostaglandin E2 (PGE2) and cyclooxygenase (COX)-2 by nonsteroidal anti-inflammatory drugs reduces the progression of colon cancer. Inhibition of aldose reductase (AR; EC. 1.1.1.21.) by sorbinil or by antisense ablation prevented fibrob
Publikováno v:
Cancer Research. 64:1875-1885
Although the amplified in breast cancer 1 (AIB1) coactivator is amplified and overexpressed in breast cancers, its role in mammary carcinogenesis remains unknown. We demonstrate that during mammary development and tumorigenesis, the elevation of AIB1