Zobrazeno 1 - 10
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pro vyhledávání: ''
Autor:
Tessa Cigler, Naomi Kornhauser, Vivek Mittal, Alysia Wiener, Amy D. Willis, Maureen M. Ward, Linda T. Vahdat, JD Warren, Anne Moore, Veronica Fitzpatrick, Anna Rubinchik, S Sahota, M Cobham, D Ko, A De Laurentiis, N Prima, Sarah E. Schneider, Eleni Andreopoulou
Publikováno v:
Cancer Research. 78:P1-10
Background: Metals have emerged as a viable therapeutic target for a new generation of anti-cancer and anti-metastatic agents. Copper, an essential trace element, serves as an important catalytic cofactor in several biological functions and has emerg
Autor:
Tobias Xiao Dong, Rui Xie, Jingyu Xu, Hanxing Wan, Hui Dong, John M. Carethers, Ya-Han Fan, Jilin Wu, Bo Tang, Michael X. Zhu, Yu-Yun Wu, Jingjing Liu, Shi-Ming Yang, Suming Wang, Yu-Feng Xiao
Publikováno v:
Cancer Research. 77:6499-6512
Although dietary calcium intake has long been recommended for disease prevention, the influence of calcium in development of cancer in the upper gastrointestinal tract has not been explored. Here, we assess the roles of calcium and calcium-sensing re
Autor:
Yingjun Zhao, Jiwei Zhang, Zhixiang Hu, Ming Yao, Tao Yu, Hongyu Pan, Xianghuo He, Hechun Lin, Dandan Chu, Mingxia Yan, Jing Li, Shengli Li, Bing Chen, Zhe Li, Xiao Zhang, Lei Liu
Publikováno v:
Cancer Research. 77:5782-5794
Long noncoding RNAs (lncRNA) participate in carcinogenesis and tumor progression in lung cancer. Here, we report the identification of a lncRNA signature associated with metastasis of non–small cell lung cancer (NSCLC). In particular, elevated expr
Autor:
Valentina Labanca, Stefania Orecchioni, Francesco Bertolini, Andrea Manconi, Cristina Rabascio, Francesca Reggiani, Patrizia Mancuso, Giovanna Talarico
Publikováno v:
Cancer Research. 77:5169-5182
A cell population with progenitor-like phenotype (CD45-CD34+) resident in human white adipose tissue (WAT) is known to promote the progression of local and metastatic breast cancer and angiogenesis. However, the molecular mechanisms of the interactio
Autor:
Ling Cen, Sweta Dash, Andrew Smith, Sean Yoder, Chaomei Zhang, Tania Mesa, Guillermo N. Armaiz-Pena, Alvaro N.A. Monteiro, Jamie K. Teer
Publikováno v:
Cancer Research. 81:736-736
Chronic stress induced by repetitive activation of the sympathetic nervous system leads to rapid release of catecholamines like norepinephrine (NE). Several studies have shown that increased levels of NE can contribute to tumor progression by promoti
Publikováno v:
Cancer Research. 81:2561-2561
Breast cancer is a rare but aggressive disease in men. Approximately, 90% of all breast cancer in men are invasive carcinomas, 25% of which have distant metastasis at the time of clinical presentation. Obesity is a risk factor for breast cancer. Mono
Autor:
Finn Cilius Nielsen, Olga Oestrup, Ulrik Lassen, Hans Skovgaard Poulsen, Petra Hamerlik, Jane Skjøth-Rasmussen, Christina Westmose Yde, Dorte Schou Noeroexe
Publikováno v:
Cancer Research. 81:444-444
Introduction: Glioblastoma (GBM) is a heterogenous cancer with a high degree of intratumoral subclonality. We foresee that future treatment will be a combination of non-targeted and targeted therapies against molecular features of each patient. In or
Autor:
ES Hwang, Carlo C. Maley, Lorraine M. King, Elaine R. Mardis, Allison Hall, Y Ding, AG Rodrigo, Jeffrey R. Marks
Publikováno v:
Cancer Research. 77:P1-06
Purpose: Intratumoral heterogeneity is well recognized to be an important driver of treatment resistance and metastasis. We undertook this N of one study to measure the degree of heterogeneity in a single large preinvasive lesion with an invasive com
Publikováno v:
Cancer Research. 76:3732-3743
Tumor size is strongly correlated with breast cancer metastasis and patient survival. Increased tumor size contributes to hypoxic and metabolic gradients in the solid tumor and to an aggressive tumor phenotype. Thus, it is important to develop three-
Autor:
Martin Reck, Heimo Mairbäurl, Karin Müller-Decker, Marvin Wäsch, Torsten Goldmann, Ekkehard Vollmer, Reiner Siebert, Swetlana Scheufele, Sofia Depner, Ruth Merkle, Ole Ammerpohl, Magdalena Szczygiel, Sebastian Marwitz, Philippe Lucarelli, Maren Kröger, Christian Kugler, Ursula Klingmüller, Dmytro Dvornikov, Klaus F. Rabe
Publikováno v:
Cancer Research. 76:3785-3801
Non–small cell lung cancer (NSCLC) is characterized by early metastasis and has the highest mortality rate among all solid tumors, with the majority of patients diagnosed at an advanced stage where curative therapeutic options are lacking. In this