Zobrazeno 1 - 10
of 26
pro vyhledávání: '"11"'
Autor:
Mohamed Rahmani, Andrea Ferreira-Gonzalez, Rebecca E. Parker, Steven Grant, Xin-Yan Pei, Maciej Kmieciak, Jewel Nkwocha, Deepak Sampath, Elisa Hawkins, Joel D. Leverson
Publikováno v:
Cancer Research. 78:3075-3086
Inhibitors targeting BCL-2 apoptotic proteins have significant potential for the treatment of acute myeloid leukemia (AML); however, complete responses are observed in only 20% of patients, suggesting that targeting BCL-2 alone is insufficient to yie
Autor:
Yvonne Parker, Jennifer C Hu, Dale Grabowski, Claudiu V. Cotta, Sujatha Chilakala, James G. Phillips, Fei Zhong, Shravya Govindgari, Rebecca R Kuang, Daniel J. Lindner, Yan Xu, Babal K. Jha, Samantha Tall, Sergei Vatolin, Mitchell R. Smith, Frederic J. Reu, Clark W. Distelhorst
Publikováno v:
Cancer Research. 76:3340-3350
Multiple myeloma cells secrete more disulfide bond–rich proteins than any other mammalian cell. Thus, inhibition of protein disulfide isomerases (PDI) required for protein folding in the endoplasmic reticulum (ER) should increase ER stress beyond r
Autor:
James J. Vornov, Ying Wu, Kenichi Nomoto, Larisa Reyderman, Nancy Wong, Christopher DesJardins, Yanke Yu, Bruce A. Littlefield, Krystyna M. Wozniak, W. George Lai, Barbara S. Slusher
Publikováno v:
Cancer Research. 76:3332-3339
Chemotherapy-induced peripheral neuropathy is a dose-limiting side effect of many antineoplastic agents, but the mechanisms underlying the toxicities are unclear. At their MTDs, the microtubule-binding drugs paclitaxel and ixabepilone induce more sev
Autor:
Taku Wakabayashi, Daisuke Eino, Fumitaka Muramatsu, Keitaro Yamane, Tomohiro Iba, Kazuhiro Takara, Nobuyuki Takakura, Hiroyasu Kidoya, Hisamichi Naito
Publikováno v:
Cancer Research. 76:3200-3210
Angiogenesis plays a crucial role in tumor growth, with an undisputed contribution of resident endothelial cells (EC) to new blood vessels in the tumor. Here, we report the definition of a small population of vascular-resident stem/progenitor–like
Autor:
Li Huang, Victor G. Prieto, Menashe Bar-Eli, Einav Shoshan, Mayra E. Vasquez, Russell R. Braeuer, Takafumi Kamiya, Gabriel J. Villares, Aaron K. Mobley, Guermarie Velazquez-Torres, Cristina Ivan, Nitin Chakravarti
Publikováno v:
Cancer Research. 76:3145-3155
Nuclear factor of activated T cell (NFAT1, NFATC2) is a transcription factor that binds and positively regulates IL2 expression during T-cell activation. NFAT1 has important roles in both innate and adaptive immune responses, but its involvement in c
Autor:
Amber M. Cumpian, Soudabeh Daliri, Seyed Javad Moghaddam, Mauricio S. Caetano, Stephanie S. Watowich, Cesar E. Ochoa, Nese Unver, Humam Kadara, Huiyuan Zhang, Seon Hee Chang, Lei Gong, Carmen Behrens, Samir M. Hanash, Carlos Gil Ferreira, Cinthya Sternberg, Edwin J. Ostrin, Ignacio I. Wistuba
Publikováno v:
Cancer Research. 76:3189-3199
Activating mutations of K-ras are the most common oncogenic alterations found in lung cancer. Unfortunately, attempts to target K-ras–mutant lung tumors have thus far failed, clearly indicating the need for new approaches in patients with this mole
Publikováno v:
Cancer Research. 80:P3-03
Background: The mechanism of induction of apoptosis has been one of the features to characterize and classify anti-tumor drugs. We have standardized a mechanism-based approach to identify apoptosis in live tumor cells by triple co-fluorescence (De et
Autor:
Beat Bornhauser, Eugenia Riveiro, Francesco Bertoni, Giosuè Costa, Filippo Spriano, Chiara Tarantelli, Emanuele Zucca, Natalina Pazzi, Matilde Guala, Stefano Alcaro, Anastasios Stathis, Francesco Trapasso, Yi-Chien Tsai, Francesco Paduano, Gaetanina Golino, Antonio Lupia, Roberta Rocca, Silvia Jenni, Eugenio Gaudio, Luciano Cascione, Franco Cavalli
Publikováno v:
Cancer Research. 79:4796-4796
Introduction: Despite the improvements, still too many patients die for their lymphomas and novel compounds are needed. We present a new small molecule, EG-011 (PCT/EP2018/057678), with in vitro and in vivo anti-cancer activity in lymphoma models. Me
Autor:
Felix Sahm, Michael Platten, Gilles J. Guillemin, Bernhard Radlwimmer, Iris Oezen, Seray Adams, Christiane A. Opitz, Andreas von Deimling, Helge B. Bode, Tilman Ahrendt, Wolfgang Wick
Publikováno v:
Cancer Research. 73:3225-3234
Quinolinic acid is a product of tryptophan degradation and may serve as a precursor for NAD+, an important enzymatic cofactor for enzymes such as the DNA repair protein PARP. Pathologic accumulation of quinolinic acid has been found in neurodegenerat
Autor:
Yuan Song, Yan Wu, Lei Lei, Yonghao Liu, Dedy Sandikin, Haiyan Liu, Dandan Lin, Bo Hu, Yinsheng Zhang, Guangming Bao, Lixiang Zhao, Yu Mei, Ziqi Jin, Xiao Yu, Chunliang Liu
Publikováno v:
Cancer research. 76(11)
Hepatocellular carcinoma is a worldwide health problem with limited treatment options and poor prognosis. Inflammation associated with liver injury and hepatocyte regeneration can lead to fibrosis, cirrhosis, and eventually, hepatocellular carcinoma.