Zobrazeno 1 - 10
of 1 084
pro vyhledávání: ''
Publikováno v:
Cancer Res
Patients with cancer are more susceptible to be infected by SARS-CoV-2 and develop severe outcomes including ICU admittance, mechanical ventilator support, and a high rate of mortality. Like mid-to late-stage cancer, SARS-CoV-2 infection is associate
Autor:
Michael Z. Gilcrease, Jeffrey T. Chang, Lei Huo, Rosanna Lau, Helen Piwnica-Worms, Giulio Draetta, Beatriz E. Adrada, Gaiane M. Rauch, Sahil Seth, Andrew Futreal, William Fraser Symmans, S. L. Moulder
Publikováno v:
Cancer Research. 79:P3-07
Triple-negative breast cancer is a highly diverse group of cancers, with poor prognosis, and currently, there are no targeted drugs available in the clinic. In TNBC around 50% percent of the patients respond to chemotherapy, while, the other 50% perc
Autor:
S Kasimir-Bauer, M Rauner, A-K Bittner, A Goebel, Tilman D. Rachner, Oliver Hoffmann, R Kimmig, LC Hofbauer
Publikováno v:
Cancer Research. 79:P6-09
Background: Periostin, also known as osteoblast-specific factor OSF-2, functions as a ligand for integrins to support adhesion and migration of tumor cells which leads to increased cell survival, invasion, angiogenesis and metastasis in different can
Autor:
Valentina Labanca, Stefania Orecchioni, Francesco Bertolini, Andrea Manconi, Cristina Rabascio, Francesca Reggiani, Patrizia Mancuso, Giovanna Talarico
Publikováno v:
Cancer Research. 77:5169-5182
A cell population with progenitor-like phenotype (CD45-CD34+) resident in human white adipose tissue (WAT) is known to promote the progression of local and metastatic breast cancer and angiogenesis. However, the molecular mechanisms of the interactio
Autor:
Michel Bouvier, Stephan Schann, Arturo Mancini, Xavier Leroy, Florence Gross, Guilhem Dugast, Laurent Sabbagh, Hiroyuki Kobayashi
Publikováno v:
Cancer Research. 81:LB187-LB187
EGFR is involved in key biological processes and its deregulation is associated with the development of many cancers. EGFR is implicated in tumor invasion, metastasis and angiogenesis. Moreover, intrinsic and acquired mutations of EGFR have been desc
Autor:
James DeVoti, Vincent R. Bonagura, Bethany Bustamante, Chris J. Papayannakos, Gary L. Goldberg, Mohd Israr, Fung Lam, Bettie M. Steinberg
Publikováno v:
Cancer Research. 81:LB259-LB259
Background and objective: COX2, an enzyme that metabolizes arachidonic acid to prostaglandin E2 (PGE2), contributes to the development of cervical dysplasia and cancer by inhibiting the immune response in the tumor micro-environment, as well as promo
Autor:
Xin Li, Liqiu Liao, Lotfi Chouchane, Lili Tang, Tuo Zhang, Xiaojing Ma, Yihang Pan, Lixing Zhang, Mei Song
Publikováno v:
Cancer Research. 77:2090-2101
Patients with triple-negative breast cancers (TNBC) are at high risk for recurrence and metastasis at an early time despite standard treatment, underscoring the need for novel therapeutic modalities. Here, we report for the first time a distinctive a
Publikováno v:
Cancer Research. 77:P6-12
SBT-100 is a single domain antibody (sdAb), developed by Singh Biotechnology, that binds unphosphorylated signal transducer and activator of transcription 3 (STAT3) and phosphorylated STAT3 (P-STAT3). SBT-100 is approximately 13 kD or less than 1/10t
Autor:
Heather M. Kling, Beth-Ann Lesnikoski, Clodia Osipo, Gordan Srkalovic, William Audeh, Patricia A. Robinson, Josien C. Haan, Kaylan Banda, Jennifer A. Crozier
Publikováno v:
Cancer Research. 81:PS18-03
Background: Invasive lobular carcinoma (ILC) comprises 10-15% of breast tumors and is the second most common histological type after invasive ductal carcinoma (IDC). Patients with ILC are often diagnosed at an older age and more advanced stage than t
Autor:
Sei-ichiro Motegi, Akihito Uehara, Sachiko Ogino, Yuko Takeuchi, Osamu Ishikawa, Mark C. Udey, Buddhini Perera, Yoko Yokoyama, Akihiko Uchiyama, Kazuya Yamada
Publikováno v:
Cancer Research. 76:4283-4292
Secretion of the powerful angiogenic factor MFG-E8 by pericytes can bypass the therapeutic effects of anti-VEGF therapy, but the mechanisms by which MFG-E8 acts are not fully understood. In this study, we investigated how this factor acts to promote