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Autor:
Valentina Labanca, Stefania Orecchioni, Francesco Bertolini, Andrea Manconi, Cristina Rabascio, Francesca Reggiani, Patrizia Mancuso, Giovanna Talarico
Publikováno v:
Cancer Research. 77:5169-5182
A cell population with progenitor-like phenotype (CD45-CD34+) resident in human white adipose tissue (WAT) is known to promote the progression of local and metastatic breast cancer and angiogenesis. However, the molecular mechanisms of the interactio
Publikováno v:
Cancer Research. 76:P1-16
Clinical trials and epidemiological evidence show that combined estrogen (E) and progestin (P) hormone replacement therapy (HRT) increases the risk of breast cancer in postmenopausal women, whereas HRT containing E alone does not. Tumor progression i
Autor:
Leying Zhang, Hiroshi Yamamoto, Anna Carolina Carvalho da Fonseca, Junling Liang, Ian Y. Zhang, Shihua Wu, Behnam Badie, Xuebo Chen, Huaqing Wang, Rama Natarajan, Yasuhiko Yamamoto, Lihong Weng, Mao Ouyang
Publikováno v:
Cancer Research. 74:7285-7297
Interaction of RAGE (the receptor for advanced glycation endproducts) with its ligands can promote tumor progression, invasion, and angiogenesis. Although blocking RAGE signaling has been proposed as a potential anticancer strategy, functional contri
Autor:
Eun-Jin Yeo, Ian P. Lewkowich, Jiufeng Li, Bin-Zhi Qian, Yihong Wang, Richard A. Lang, Luca Cassetta, James A. Stefater, April N. Smith, Jeffrey W. Pollard, Lisa Wiechmann
Publikováno v:
Cancer Research. 74:2962-2973
Oncogenic targets acting in both tumor cells and tumor stromal cells may offer special therapeutic appeal. Interrogation of the Oncomine database revealed that 52 of 53 human breast carcinomas showed substantial upregulation of WNT family ligand WNT7
Autor:
James Brugarolas, Jeffrey A. Cadeddu, Allison Joyce, Vitali Margulis, Ananth J. Madhuranthakam, Qurratulain Yousuf, DK Dwivedi, Ivan Pedrosa, Payal Kapur, Michael Fulkerson, Asghar Hajibeigi, Aditya Bagrodia, Ze Zhang, Durga Udayakumar, Alberto Diaz de Leon, Yin Xi, Tao Wang, Matthew A. Lewis
Publikováno v:
Cancer Research. 79:1397-1397
Clear cell renal cell carcinoma (ccRCC) is primarily driven by mutation in von Hippel-Lindau (VHL) leading to constitutive hypoxia inducible factors (HIFs) upregulation promoting angiogenesis. ccRCC is the most aggressive and common histological subt
Autor:
Melody A. Swartz, Jan Liphardt, Shelley Hwang, Brian Ruffell, Irene Acerbi, C Yunn-Yi, Quanming Shi, Valerie M. Weaver, Hongmei Yu, Jennifer M. Munson, Alfred Au, Jonathan N. Lakins, LM Coussen, Janna K. Mouw, S. Zheng
Publikováno v:
Cancer Research. 73:S2-06
Tumor progression is influenced by the dynamic interplay between the genetically-modified epithelium and the associated microenvironment. We previously showed that the extra-cellular matrix (ECM) progressively stiffens as mammary tumors evolve, and t
Autor:
Laura A. Fung, Daniela F. Quail, David A. Hess, Guihua Zhang, Amber Ablack, Logan A. Walsh, John D. Lewis, Scott D. Findlay, Juan C. Moreno, Susan J. Done, Lynne-Marie Postovit
Publikováno v:
Cancer Research. 72:3851-3863
Tumor vascularization is requisite for breast cancer progression, and high microvascular density in tumors is a poor prognostic indicator. Patients bearing breast cancers expressing human embryonic stem cell (hESC)-associated genes similarly exhibit
Autor:
Donatella Regano, Lorena Zentilin, Mauro Giacca, Federica Maione, Federico Bussolino, Guido Serini, Enrico Giraudo, Stefania Capano
Publikováno v:
Cancer Research. 72:SY41-04
The critical role of angiogenesis in tumor development, progression and metastatization has long been appreciated and several anti-angiogenic inhibitors are approved for use in cancer therapy. Recently it has been reported in pre-clinical mouse model
Publikováno v:
Cancer Research. 70:8211-8221
Vascular endothelial growth factor and its receptors, including Flt-1 and Flk-1, are involved in angiogenesis under physiologic and pathologic conditions. Recently, Flt-1–expressing cells were reported to contribute to the intracranial growth of gl
Autor:
Jean-Baptiste, Vincourt, Stéphanie, Etienne, Justine, Cottet, Camille, Delaunay, Claudie Bantsimba, Malanda, Bantsimba, Malanda, Frédéric, Lionneton, François, Sirveaux, Patrick, Netter, François, Plénat, Didier, Mainard, Jean-Michel, Vignaud, Jacques, Magdalou
Publikováno v:
Cancer Research. 70:4739-4748
Chondrogenic tumors that exhibit benign or malignant behaviors synthesize variable amounts of cartilage-like extracellular matrix. To define the regulators of these phenotypes, we performed a proteomic comparison of multiple human chondrogenic tumors