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Publikováno v:
Cancer Research. 72:415-415
Recent reports revealed that endothelial progenitor cells (EPCs) isolated from bone marrow, cord blood or embryos have been experimentally utilized to deliver therapeutic agents for cancer treatment. Their potential in cancer therapy highlights the n
Publikováno v:
Cancer Research. 72:C62-C62
There are multiple pieces of evidence that the sympathetic nervous system and thyroid hormones play crucial roles in normal and cancerous development of tissues. It is well established that chronic β-adrenergic stimulation (cAMP-PKA-CREB pathway) is
Autor:
Zena Werb
Publikováno v:
Cancer Research. 71:IA11-IA11
Both extrinsic and intrinsic mechanisms regulate the development of the aberrant tumor organ and regulate its progression. We have used genetic and in vivo imaging techniques to study the interaction between epithelial cancer cells and the tumor micr
Autor:
Jeff Caplan, Renee Kirk, Christine Reilly, Maria Scrivens, Maurice Zauderer, Mark Paris, Alan Howell, Laurie A. Winter, Raymond Watkins, Sebold Torno, Holm Bussler, He Huang, Patrick Kenney, Ernest S. Smith, Terrence L. Fisher, Leslie A. Croy, Elizabeth E. Evans, Alan S. Jonason, John E. Leonard
Publikováno v:
Cancer Research. 71:3667-3667
Semaphorin 4D (SEMA4D; CD100) has been implicated in several key mechanisms of tumor progression, including neovascularization, tumor invasion, and metastasis. SEMA4D binding to its receptor plexin-B1 (PLXNB1) on endothelial cells transactivates MET
Autor:
Christina S. Kong, Donna M. Bouley, Alice Banh, Amato J. Giaccia, Albert C. Koong, Shirley Kwok, Jing Zhang, Quynh-Thu Le, Hongbin Cao
Publikováno v:
Cancer Research. 71:1557-1557
Studies have shown that Galectin-1 (Gal-1), a carbohydrate-binding protein whose secretion is enhanced under hypoxia, can promote tumor aggressiveness through its effect on angiogenesis and T-cell apoptosis. However, the importance of tumor versus ho
Autor:
Masashi Muramatsu, Feng Wang, Rika Tsuchida, Masabumi Shibuya, Tsuyoshi Osawa, Yasuhito Yuasa
Publikováno v:
Cancer Research. 71:4270-4270
Anti-angiogenesis is an effective cancer treatment, however, tumor progression and refractoriness to anti-angiogenesis are observed in both clinical and preclinical cancer models. Stress under hypoxia and nutrition deprivation might play an important
Publikováno v:
Cancer Research. 71:5143-5143
Vascular endothelial growth factor A (VEGFA) is a cytokine implicated in proliferation, migration and cell survival that mediates its effects through its major receptor, VEGFR2. VEGFA is highly induced by hypoxia and is a crucial regulator of angioge
Autor:
Motoyoshi Tanaka, Nobutaka Shimizu, Ayaka Izumi, Marco A. De Velasco, Makiko Doi, Kazuhiro Yoshikawa, Yuji Hatanaka, Kazuhiro Yoshimura, Masahiro Nozawa, Yutaka Yamamoto, Kazuto Nishio, Erina Okazaki, Hirotsugu Uemura
Publikováno v:
Cancer Research. 71:3579-3579
Background: Current estimates suggest that PI3K/Akt/mTOR signaling is upregulated in 30-50% of prostate cancers (PCa), namely through loss of Pten. Although Ras mutations in prostate cancer are infrequent, wild-type Ras is chronically activated in PC
Publikováno v:
Cancer Research. 71:3393-3393
Emerging evidence indicate that the capacity of a tumor to grow and propagate resides primarily in a small population of tumor cells, which are known as cancer stem cells. The origin of these cancer stem cells remains controversial. Hypoxia promotes
Autor:
Ralf Brandt, Paul Handley, Edward Hammond, Jessica Rowley, Keith Dredge, Christina Vincent, Ian Bytheway
Publikováno v:
Cancer Research. 71:1461-1461
PG545 is a fully synthetic heparan sulfate (HS) mimetic entering Phase I clinical trials for advanced cancer. PG545 inhibits key processes in tumor progression (a) angiogenesis – by interfering with growth factor binding and (b) metastasis – by i