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Autor:
Valentina Labanca, Stefania Orecchioni, Francesco Bertolini, Andrea Manconi, Cristina Rabascio, Francesca Reggiani, Patrizia Mancuso, Giovanna Talarico
Publikováno v:
Cancer Research. 77:5169-5182
A cell population with progenitor-like phenotype (CD45-CD34+) resident in human white adipose tissue (WAT) is known to promote the progression of local and metastatic breast cancer and angiogenesis. However, the molecular mechanisms of the interactio
Autor:
Leying Zhang, Hiroshi Yamamoto, Anna Carolina Carvalho da Fonseca, Junling Liang, Ian Y. Zhang, Shihua Wu, Behnam Badie, Xuebo Chen, Huaqing Wang, Rama Natarajan, Yasuhiko Yamamoto, Lihong Weng, Mao Ouyang
Publikováno v:
Cancer Research. 74:7285-7297
Interaction of RAGE (the receptor for advanced glycation endproducts) with its ligands can promote tumor progression, invasion, and angiogenesis. Although blocking RAGE signaling has been proposed as a potential anticancer strategy, functional contri
Autor:
Carine Michiels, Olivier Feron, Vincent Grégoire, Florence Lair, Chantal Dessy, Florence Defresne, Caroline Bouzin, Julie Saliez, Philippe Martinive
Publikováno v:
Cancer Research. 66:11736-11744
Hypoxia is a common feature in tumors associated with an increased resistance of tumor cells to therapies. In addition to O2 diffusion–limited hypoxia, another form of tumor hypoxia characterized by fluctuating changes in pO2 within the disorganize
Autor:
Neus Martínez-Bosch, Fraņ Coise Poirier, Mireia Moreno, Hans-Joachim Gabius, Pilar Navarro, Jessica Munné-Collado, Martin E. Fernandez-Zapico, Sabine André, Carmen Guerra, Elena Ortiz-Zapater, Maite G. Fernandez-Barrena, Carolina Navas, Rosa F. Hwang, Mar Iglesias
Publikováno v:
Cancer Research
Cancer Research, American Association for Cancer Research, 2014, epub ahead of print. ⟨10.1158/0008-5472.CAN-13-3013⟩
Cancer Research, American Association for Cancer Research, 2014, epub ahead of print. ⟨10.1158/0008-5472.CAN-13-3013⟩
Pancreatic ductal adenocarcinoma (PDA) is the most aggressive tumor, showing incidence and mortality values almost identical. Despite remarkable advances in PDA molecular characterization, this disease is still refractory to current treatments. Desmo
Autor:
Daniel G. Anderson, James V. McCann, Lin Xiao, Piotr S. Kowalski, Omar F. Khan, Salma H. Azam, Andrew C. Dudley, Chad V. Pecot
Publikováno v:
Cancer Research. 76:A47-A47
Tumor-associated endothelial cells (TECs) are dysfunctional and leak fibrin which is resolved (fibrinolysis) and replaced with collagen in a process that closely resembles wound healing. Because degraded perivascular fibrin also promotes angiogenesis
Publikováno v:
Cancer Research. 76:C09-C09
The breast tumor microenvironment (TME) is a diverse area where complex interactions between the extra-cellular matrix (ECM) and multiple cell types (tumor epithelial, endothelial, and inflammatory cells, fibroblasts, and adipocytes) occur resulting
Publikováno v:
Cancer Research. 76:902-902
The cellular and molecular composition of the pancreatic tumor microenvironment includes a complex matrix that encases tumor cells and presents a conundrum in respect to therapy. The dense desmoplasia that accompanies tumor growth reduces blood flow
Autor:
Xiaoli Dong, Tongchao Sun, Rongrong Wang, Chenhua Yu, Rong Xiang, Xuefei Li, Yingxi Xu, Na Li, Weijun Su
Publikováno v:
Cancer Research. 76:2499-2499
Angiogenesis plays an important role during the development of tumor. Sox2 is one of the transcription factors involved in tumorigenesis and metastasis. However, its function during the process of tumor angiogenesis and lymphogenesis is still poorly
Publikováno v:
Cancer Research. 75:429-429
Obesity has been shown to increase prostate cancer (PCa) progression and disease severity in men. In previous studies, we showed that diet-induced obesity (DIO, 60 kcal% fat) increased the incidence and severity of invasive adenocarcinomas in HiMyc t
Autor:
Gabriel Mandarini Doho, Marina Gobbe Moschetta, Thaiz Ferraz Borin, Mateus Repolês Lourenço, Bruna Victorasso Jardim-Perassi, Lívia Carvalho Ferreira, Gabriela Bottaro Gelaleti, Debora de Campos Zuccari
Publikováno v:
Cancer Research. 75:P6-04
The rapid tumor growth results in hypoxia on tumor microenvironment, leading to a cascade of events that induce angiogenesis and subsequent cancer progression. Thus, the identification of therapeutic agents that can inhibit angiogenesis is essential