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Autor:
Leying Zhang, Hiroshi Yamamoto, Anna Carolina Carvalho da Fonseca, Junling Liang, Ian Y. Zhang, Shihua Wu, Behnam Badie, Xuebo Chen, Huaqing Wang, Rama Natarajan, Yasuhiko Yamamoto, Lihong Weng, Mao Ouyang
Publikováno v:
Cancer Research. 74:7285-7297
Interaction of RAGE (the receptor for advanced glycation endproducts) with its ligands can promote tumor progression, invasion, and angiogenesis. Although blocking RAGE signaling has been proposed as a potential anticancer strategy, functional contri
Publikováno v:
Cancer Research. 70:8211-8221
Vascular endothelial growth factor and its receptors, including Flt-1 and Flk-1, are involved in angiogenesis under physiologic and pathologic conditions. Recently, Flt-1–expressing cells were reported to contribute to the intracranial growth of gl
Autor:
Robert M. Hoffman, Shan Man, Yuval Shaked, Robert S. Kerbel, Terence Tang, Chris Folkins, Christina R. Lee, Zhenping Zhu
Publikováno v:
Cancer Research. 69:7243-7251
Cancer stem cells (CSC) are predicted to be critical drivers of tumor progression due to their self-renewal capacity and limitless proliferative potential. An emerging area of research suggests that CSC may also support tumor progression by promoting
Publikováno v:
Cancer Research. 67:11760-11768
Failed therapies directed against matrix metalloproteinases (MMP) in cancer patients may be attributed, in part, to lack of diagnostic tools to differentiate between pro-MMPs and active MMPs, which indicate whether a treatment is efficacious or not.
Autor:
Carine Michiels, Olivier Feron, Vincent Grégoire, Florence Lair, Chantal Dessy, Florence Defresne, Caroline Bouzin, Julie Saliez, Philippe Martinive
Publikováno v:
Cancer Research. 66:11736-11744
Hypoxia is a common feature in tumors associated with an increased resistance of tumor cells to therapies. In addition to O2 diffusion–limited hypoxia, another form of tumor hypoxia characterized by fluctuating changes in pO2 within the disorganize
Publikováno v:
Cancer Research. 66:9202-9210
We tested the hypothesis that cell invasiveness and tumorigenesis are driven by hypomethylation of genes involved in tumor progression. Highly invasive human prostate cancer cells PC-3 were treated with either the methyl donor S-adenosylmethionine (S
Autor:
Mizue Inoue, Ippei Sugihara, Noriko Takeuchi, Hiroshi Nakada, Munetoyo Toda, Koji Maruyama, Masanobu Yoshida, Hiroaki Takagi, Tatsuro Shigenobu
Publikováno v:
Cancer Research. 66:6175-6182
Previously, we found that MUC2 mucins could activate monocytes/macrophages through a scavenger receptor leading to cyclooxygenase (COX) 2 induction and overproduction of prostaglandin E2 (PGE2). To investigate the role of mucins in the tumor-bearing
Autor:
Hellmut G. Augustin, Christian Dullin, Jelena Krneta, Jens Kroll, Claudia Prahst, Sarah Kimmina, David James Phillips, Farahnaz Sananbenesi, Frauke Alves
Publikováno v:
Cancer Research. 66:5686-5695
The transforming growth factor-β superfamily member activin and its antagonist, follistatin, act as a pleiotropic growth factor system that controls cell proliferation, differentiation, and apoptosis. Activin inhibits fibroblast growth factor 2–in
Autor:
Ichiro Yoshino, Kazunori Nakagawa, Katsuo Sueishi, Shinji Okano, Shihoko Sata, Takaomi Koga, Toshiaki Nakano, Mitsuho Onimaru, Yoshikazu Yonemitsu, Yoshihiko Maehara, Yasunori Shikada
Publikováno v:
Cancer Research. 65:7241-7248
It is widely accepted that angiogenesis is required for tumor progression. Vascular endothelial growth factor (VEGF) is a key molecule for tumor angiogenesis; however, its expressional regulation is not well understood during all stages of tumorigene
Autor:
Stephanie Filleur, Emelyn H. Shroff, Tetiana Zaichuk, Dorina Veliceasa, Yelena Mirochnik, Olga V. Volpert, S. P. Becerra, Hanhua Huang, Maria S. Aymerich, Karl Volz, Thomas Nelius, Ronald L. Yap
Publikováno v:
Cancer Research. 65:5144-5152
Pigment epithelial-derived factor (PEDF), an angiogenesis inhibitor with neurotrophic properties, balances angiogenesis in the eye and blocks tumor progression. Its neurotrophic function and the ability to block vascular leakage is replicated by the