Zobrazeno 1 - 10
of 90
pro vyhledávání: ''
Autor:
Yukyung Jun, Yun-Suhk Suh, SungHee Park, Jieun Lee, Jong-Il Kim, Sanghyuk Lee, Wan-Ping Lee, Olga Anczuków, Han-Kwang Yang, Charles Lee
Publikováno v:
Cancer Research. 82:543-555
Alternatively spliced RNA isoforms are a hallmark of tumors, but their nature, prevalence, and clinical implications in gastric cancer have not been comprehensively characterized. We systematically profiled the splicing landscape of 83 gastric tumors
Autor:
Shun-Qing Liang, Haibin Deng, Ren-Wang Peng, Gregor J. Kocher, Sabina Berezowska, Qinghua Zhou, Zhang Yang, Rémy Bruggmann, Sean Hall, Yanyun Gao, Duo Xu, Thomas M. Marti, Ralph A. Schmid, Haitang Yang
Publikováno v:
Cancer research, vol. 81, no. 11, pp. 3121-3133
Oncogenic activation of the FGFR pathway is frequent in lung and other cancers. However, due to drug resistance, pharmacological blockage of aberrant FGFR signaling has provided little clinical benefit in patients with FGFR-amplified tumors. The dete
Autor:
Takeshi Irie, Joshua S. Mincer, Roy Mano, Joseph R. Scarpa, Gregory W. Fischer, Fengshen Kuo, A. Ari Hakimi, Renzo G. DiNatale, Patrick J. McCormick, Andrew W. Silagy
Publikováno v:
Cancer Res
While opioids constitute the major component of perioperative analgesic regimens for surgery in general, a variety of evidence points to an association between perioperative opioid exposure and longer term oncologic outcomes. The mechanistic details
Publikováno v:
Cancer Research. 81:344-355
Circular RNAs (circRNA) are a new member of endogenously produced noncoding RNAs that have been characterized as key regulators of gene expression in a variety of malignances. However, the role of circRNA in oral squamous cell carcinoma (OSCC) remain
Autor:
Kayla J. Wolf, Jonathan Rick, Alan T. Nguyen, Sumedh S. Shah, Harsh Wadhwa, Joseph H Garcia, Sören Müller, Luke A. Gilbert, Garima Yagnik, Sanjay Kumar, Manish K. Aghi, Matheus P. Pereira, Rushikesh S. Joshi, Jung-Ming G. Lin, Jacob Weiss, Aaron Diaz, Saket Jain, William S. Chen, Arman Jahangiri, Ankush Chandra
Publikováno v:
Cancer research, vol 80, iss 7
Cancer Res
Cancer Res
Glioblastoma (GBM) responses to bevacizumab are invariably transient with acquired resistance. We profiled paired patient specimens and bevacizumab-resistant xenograft models pre- and post-resistance toward the primary goal of identifying regulators
Autor:
Wei Dong Zang, Rui Zhao, Bo Dai, Jian-Yuan Zhao, Shu Xian Zhou, Qian Zhou, Guo Hai Shi, Fu Jiang Xu, Xuan Zhang, Yi Jun Shen, Yuan-Yuan Qu, Wenhao Xu, Hai Liang Zhang, Yao Zhu, Wei Xu, Yan Lin, Yiping Zhu, Kun Chang, Ning Shao, Cheng Tao Han, Dingwei Ye, Shimin Zhao
Publikováno v:
Cancer Research. 80:319-333
The tumorigenic role and underlying mechanisms of lipid accumulation, commonly observed in many cancers, remain insufficiently understood. In this study, we identified an AMP-activated protein kinase (AMPK)–GATA-binding protein 3 (GATA3)–enoyl-Co
Autor:
Stefan Fichtner-Feigl, Lisa Marx, Eric Metzger, Mark Schmitt, Félicie Cottard, Florian R. Greten, Roland Schüle, Rebecca Kesselring, Valentina Petrocelli, Sylvia Urban, Stephan M Tirier, Karsten Rippe, Christopher Berlin, Dominica Willmann
Publikováno v:
Cancer research. 82(2)
Colorectal cancer is among the leading causes of cancer-associated deaths worldwide. Treatment failure and tumor recurrence due to survival of therapy-resistant cancer stem/initiating cells represent major clinical issues to overcome. In this study,
Autor:
Christine Desmedt, Alison Cheung, Amanda Mao, Martin J. Yaffe, Susan J. Done, Rachel Peters, Eshetu G. Atenafu, Janina Kulka, Christos Sotiriou, Melanie Dawe, Carrie X Wei, Borbála Székely, Nisha Kanwar, Shiyi Chen, Dan Wang, Fred Fu, Zaldy Balde, Ranju Nair, Yulia Yerofeyeva, Kela Liu, David R. McCready, Naoto Hirano, Manjula Maganti, Philippe L. Bedard, Sabrina Manolescu, Trevor D. McKee, John M. S. Bartlett
Publikováno v:
Kanwar, N, Balde, Z, Nair, R, Dawe, M, Chen, S, Maganti, M, Atenafu, E G, Manolescu, S, Wei, C, Mao, A, Fu, F, Wang, D, Cheung, A, Yerofeyeva, Y, Peters, R, Liu, K, Desmedt, C, Sotiriou, C, Szekely, B, Kulka, J, McKee, T D, Hirano, N, Bartlett, J, Yaffe, M J, L. Bedard, P, McCready, D & J. Done, S 2021, ' Heterogeneity of circulating tumour cell-associated genomic gains in breast cancer and its association with the host immune response. ', Cancer Research .
Tumor cells that preferentially enter circulation include the precursors of metastatic cancer. Previously, we characterized circulating tumor cells (CTC) from patients with breast cancer and identified a signature of genomic regions with recurrent co
Autor:
Jianning Zhai, Yanquan Zhang, Zengren Zhao, Junzhe Huang, Guoping Wang, Chuangen Li, Guifeng Wei, Chi Chun Wong, Liuyang Zhao, Jun Yu, Shiyan Wang, Hong Wei
Publikováno v:
Cancer Research. 79:4086-4098
Tripartite motif (TRIM) family proteins participate in a variety of important cellular processes, including apoptosis, cell-cycle arrest, DNA repair, and senescence. In this study, we demonstrated that a novel TRIM family member, TRIM67, was commonly
Publikováno v:
Cancer Research. 79:2853-2864
High temperature requirement A3 (HTRA3, long and short isoforms) is a member of the HtrA family and has been implicated as a tumor suppressor in cancer progression in multiple cancer types, yet its molecular functions in non–small cell lung cancer