Zobrazeno 31 - 40
of 1 168
pro vyhledávání: ''
Autor:
Steven A. Johnsen, Feda H. Hamdan, Elisabeth Hessmann, Christine S Gibhardt, Zeynab Najafova, Jochen Gaedcke, Philipp Ströbel, Ivan Bogeski, Volker Ellenrieder, Waltraut Kopp, Xin Wang, Ana P. Kutschat, Alexander Q. Wixom
Publikováno v:
Cancer Res
Pancreatic ductal adenocarcinoma (PDAC) displays a dismal prognosis due to late diagnosis and high chemoresistance incidence. For advanced disease stages or patients with comorbidities, treatment options are limited to gemcitabine alone or in combina
Autor:
Taylor R. Rutherford, Garhett L. Wyatt, Traci R. Lyons, Weston Porter, Lyndsey S. Crump, Jennifer K. Richer
Publikováno v:
Cancer Res
Breast cancer is a leading cause of cancer-associated death in women in the United States, and approximately 70% of all cases are estrogen receptor positive (ER+). While effective ER-targeting endocrine therapy has substantially progressed the succes
Autor:
Carsten Sticht, Carolin Mogler, Olga Ermakova, Fabian Rose, Stefan Thomann, Eduard Ryschich, Carolina De La Torre, Daniel Kazdal, Kai Breuhahn, Claudia R. Ball, Norbert Gretz, Stephanie Roessler, Simone Marquard, Sarah Fritzsche, Peter Schirmacher, S Weiler, Teng Wei, Eugen Rempel, Hanno Glimm, Marcell Tóth
Publikováno v:
Cancer Research. 80:5502-5514
The oncogene yes-associated protein (YAP) controls liver tumor initiation and progression via cell extrinsic functions by creating a tumor-supporting environment in conjunction with cell autonomous mechanisms. However, how YAP controls organization o
Autor:
Eric C. Svensson, Paul M. Ridker, Jason Baum, Bharani Bharani-Dharan, Ying A Wang, Siyan Xu, Xiaoshan Wang, Anne-Marie Martin, Margaret F. Prescott, Margaret Dugan, Michael T. Beste, Angela Silvestro, Wong Connie C, Lynne Krajkovich
Publikováno v:
Cancer Research. 80:5597-5605
In the Canakinumab Anti-inflammatory Thrombosis Outcomes Study (CANTOS), inhibition of the IL1β inflammatory pathway by canakinumab has been shown to significantly reduce lung cancer incidence and mortality. Here we performed molecular characterizat
Autor:
Laoighse Mulrane, René Bernards, William M. Gallagher, Aisling O'Connor, Lisa Dwane, Brenton Cavanagh, Annette M.G. Dirac, Brian Mooney, Elspeth Ward, Benedikt M. Kessler, Anna M. Blümel, Adan Pinto-Fernandez, Karin Jirström, Triona Ni Chonghaile, Bruce Moran, Darran P. O'Connor, Sudipto Das
Publikováno v:
Cancer Research. 80:5076-5088
Approximately 70% of breast cancers express estrogen receptor α (ERα) and depend on this key transcriptional regulator for proliferation and differentiation. While patients with this disease can be treated with targeted antiendocrine agents, drug r
Autor:
Zoila A. Lopez-Bujanda, Martha Salas, Ryota Takahashi, Gulam Abbas Manji, Catherine Do, Jarwei Fang, Timothy C. Wang, Charles G. Drake, Tamas A. Gonda, Anna Zhukovskaya, Kenneth P. Olive, Emily Hsu, Ariel Siegel, Benjamin Tycko
Publikováno v:
Cancer Res
Pancreatic ductal adenocarcinoma (PDAC) is a lethal cancer that has proven refractory to immunotherapy. Previously, treatment with the DNA hypomethylating drug decitabine (5-aza-dC; DAC) extended survival in the KPC-Brca1 mouse model of PDAC. Here we
Autor:
Sanford D. Markowitz, Joel N. Saltzman, Zhenghe Wang, Martina L. Veigl, Shaveta Vinayak, Smitha S. Krishnamurthi, Yan Xu, Zhanwen Du, Yujun Hao, Gino Cioffi, J. Eva Selfridge, Jennifer R. Eads, Xiujing Feng, Neal J. Meropol, Janet Wang, Yicheng Chen, Jill S. Barnholtz-Sloan, David L. Bajor, Shashank Gorityala, Yiqing Zhao, Ronald A. Conlon
Publikováno v:
Cancer Research. 80:4815-4827
PIK3CA encodes the p110α catalytic subunit of PI3K and is frequently mutated in human cancers, including ∼30% of colorectal cancer. Oncogenic mutations in PIK3CA render colorectal cancers more dependent on glutamine. Here we report that the glutam
Autor:
Ivan S. Alferiev, David T Guerrero, Danielle Soberman, Benjamin B. Pressly, Ferro Nguyen, Koumudi Naraparaju, Michael Chorny, Peng Guan, Venkatadri Kolla, Lauren M. Perry, Garrett M. Brodeur
Publikováno v:
Cancer Res
Camptothecins are potent topoisomerase I inhibitors used to treat high-risk pediatric solid tumors, but they often show poor efficacy due to intrinsic or acquired chemoresistance. Here, we developed a multivalent, polymer-based prodrug of a structura
Publikováno v:
Cancer Research. 80:3945-3958
Malignant glioma constitutes one of the fatal primary brain tumors in adults. Such poor prognosis calls for a better understanding of cancer-related signaling pathways of this disease. Here we elucidate a MYC-miRNA-MXI1 feedback loop that regulates p
Autor:
Yutaka Yasui, Leslie L. Robison, Carmen L. Wilson, Daniel M. Green, Yadav Sapkota, Zhaoming Wang, Melissa M. Hudson, Rikeenkumar Dhaduk, Asifa K. Zaidi, Lu Lu, Jinghui Zhang, Matthew J. Krasin, Fred B. Berry, Jessica L Baedke, Qi Liu, Wassim Chemaitilly, Klementina Fon Tacer, Wonjong Moon
Publikováno v:
Cancer Res
Exposure to high doses of alkylating agents is associated with increased risk of impaired spermatogenesis among nonirradiated male survivors of childhood cancer, but there is substantial variation in this risk. Here we conducted a genetic study for i