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of 258
pro vyhledávání: ''
Autor:
Sung Chul Lim, Youngnam Cho, Y. J. Kim, Seungmin Kang, Kyu Min Kim, Moon-Chang Baek, Keon Wook Kang, Miso Park, Ju Hyun Bae, Sung Baek Jeong, Jin Ki Kim, Dae Won Jun, Yong June Choi, Seung-Hyun Lee, Jiwon Kim, Wankyu Kim, HyungJae Lee, Sung Yun Cho
Publikováno v:
Cancer Research. 81:3539-3553
Extracellular vesicles (EV) in the tumor microenvironment have emerged as crucial mediators that promote proliferation, metastasis, and chemoresistance. However, the role of circulating small EVs (csEV) in cancer progression remains poorly understood
Autor:
Ke Cong, John J. Krais, Michelle Mosqueda, Sharon B. Cantor, Sumeet Nayak, Lihua Julie Zhu, Jianhong Ou, Min Peng, Matt Bere, Neil Johnson, Samuel M. Bond, Jennifer A. Calvo, Bin Deng, Nicholas J. Panzarino, Mihir B. Doshi
Publikováno v:
Cancer Res
Defects in DNA repair and the protection of stalled DNA replication forks are thought to underlie the chemosensitivity of tumors deficient in the hereditary breast cancer genes BRCA1 and BRCA2 (BRCA). Challenging this assumption are recent findings t
Autor:
Lei Bi, Fuqiong Zhou, Peng Meng, Bo Tang, Yidan Ren, Yunshan Wang, Yu-Cui Jiang, Weiping Chen, Qin Wang, Chuanxin Wang, Maoxiao Feng, Yuli Wang, Feiyan Chen, Qinlian Jiao, Lutao Du
Publikováno v:
Cancer Research. 81:2015-2028
Hepatocellular carcinoma (HCC) contains a subset of cancer stem cells (CSC) that cause tumor recurrence, metastasis, and chemical resistance. Histone deacetylase 11 (HDAC11) mediates diverse immune functions and metabolism, yet little is known about
Autor:
Ruth Meier, Michael Lübbert, Julia Stomper, Nadja Blagitko-Dorfs, Dennis Zimmer, Dietmar Pfeifer, Bettina Berberich, Julia Schüler, Björn Grüning, Olga Grishina, Dieter Weichenhan, Lea Gutenkunst, Christoph Plass, Gabriele Greve, Ulrike Bönisch
Publikováno v:
Cancer research : an official organ of the American Association for Cancer Research
Hypomethylating agents (HMA) have become the backbone of nonintensive acute myeloid leukemia/myelodysplastic syndrome (AML/MDS) treatment, also by virtue of their activity in patients with adverse genetics, for example, monosomal karyotypes, often wi
Autor:
Nicole S. Spoelstra, Jason Gertz, Britta M. Jacobsen, Jessica L. Christenson, Kathleen C. Torkko, Steffi Oesterreich, Anthony D. Elias, Rebecca B. Riggins, Andrew Goodspeed, Zheqi Li, Michelle M. Williams, Sharon Sams, Jordan Reese, Toru Hanamura, Spencer Arnesen, Kathleen I. O’Neill, Emmanuel Rosas, Jennifer K. Richer
Publikováno v:
Cancer Res
Mutations in ESR1 that confer constitutive estrogen receptor alpha (ER) activity in the absence of ligand are acquired by ≥40% of metastatic breast cancers (MBC) resistant to adjuvant aromatase inhibitor (AI) therapy. To identify targetable vulnera
Autor:
Steven A. Johnsen, Feda H. Hamdan, Elisabeth Hessmann, Christine S Gibhardt, Zeynab Najafova, Jochen Gaedcke, Philipp Ströbel, Ivan Bogeski, Volker Ellenrieder, Waltraut Kopp, Xin Wang, Ana P. Kutschat, Alexander Q. Wixom
Publikováno v:
Cancer Res
Pancreatic ductal adenocarcinoma (PDAC) displays a dismal prognosis due to late diagnosis and high chemoresistance incidence. For advanced disease stages or patients with comorbidities, treatment options are limited to gemcitabine alone or in combina
Autor:
Carsten Sticht, Carolin Mogler, Olga Ermakova, Fabian Rose, Stefan Thomann, Eduard Ryschich, Carolina De La Torre, Daniel Kazdal, Kai Breuhahn, Claudia R. Ball, Norbert Gretz, Stephanie Roessler, Simone Marquard, Sarah Fritzsche, Peter Schirmacher, S Weiler, Teng Wei, Eugen Rempel, Hanno Glimm, Marcell Tóth
Publikováno v:
Cancer Research. 80:5502-5514
The oncogene yes-associated protein (YAP) controls liver tumor initiation and progression via cell extrinsic functions by creating a tumor-supporting environment in conjunction with cell autonomous mechanisms. However, how YAP controls organization o
Autor:
Laoighse Mulrane, René Bernards, William M. Gallagher, Aisling O'Connor, Lisa Dwane, Brenton Cavanagh, Annette M.G. Dirac, Brian Mooney, Elspeth Ward, Benedikt M. Kessler, Anna M. Blümel, Adan Pinto-Fernandez, Karin Jirström, Triona Ni Chonghaile, Bruce Moran, Darran P. O'Connor, Sudipto Das
Publikováno v:
Cancer Research. 80:5076-5088
Approximately 70% of breast cancers express estrogen receptor α (ERα) and depend on this key transcriptional regulator for proliferation and differentiation. While patients with this disease can be treated with targeted antiendocrine agents, drug r
Autor:
Sanford D. Markowitz, Joel N. Saltzman, Zhenghe Wang, Martina L. Veigl, Shaveta Vinayak, Smitha S. Krishnamurthi, Yan Xu, Zhanwen Du, Yujun Hao, Gino Cioffi, J. Eva Selfridge, Jennifer R. Eads, Xiujing Feng, Neal J. Meropol, Janet Wang, Yicheng Chen, Jill S. Barnholtz-Sloan, David L. Bajor, Shashank Gorityala, Yiqing Zhao, Ronald A. Conlon
Publikováno v:
Cancer Research. 80:4815-4827
PIK3CA encodes the p110α catalytic subunit of PI3K and is frequently mutated in human cancers, including ∼30% of colorectal cancer. Oncogenic mutations in PIK3CA render colorectal cancers more dependent on glutamine. Here we report that the glutam
Publikováno v:
Cancer Research. 80:3945-3958
Malignant glioma constitutes one of the fatal primary brain tumors in adults. Such poor prognosis calls for a better understanding of cancer-related signaling pathways of this disease. Here we elucidate a MYC-miRNA-MXI1 feedback loop that regulates p