Zobrazeno 1 - 10
of 10
pro vyhledávání: ''
Autor:
Kosuke Hiramatsu, Tetsuji Naka, Takayuki Enomoto, Shinya Matsuzaki, Akiko Morimoto, Satoshi Nojima, Satoshi Nakagawa, Tadashi Kimura, Eiichi Morii, Minoru Fujimoto, Kiyoshi Yoshino, Takuhei Yokoyama, Hiroshi Takemori, Yutaka Ueda, Tsuyoshi Takahashi, Yusuke Takahashi, Satoshi Serada
Publikováno v:
Cancer Research. 78:516-527
Epithelial ovarian cancer (EOC) is the most lethal gynecologic malignancy, but it still lacks effective treatment options. In this study, we utilized proteomic technology to identify lipolysis-stimulated lipoprotein receptor (LSR) as a new tumor anti
Autor:
Olivia C. Campbell, Pamela Norberg, Gordana Vlahovic, Kendra L. Congdon, Kent J. Weinhold, Elizabeth A. Reap, Katherine A. Riccione, Adam M. Swartz, James E. Herndon, Anirudh Saraswathula, Duane Mitchell, Allan H. Friedman, Darell D. Bigner, Patrick Healy, Roger E. McLendon, John H. Sampson, Henry S. Friedman, Luis Sanchez-Perez, Peter E. Fecci, John S. Yi, Smita K. Nair, Patrick C. Gedeon, Mohammed K. Hossain-Ibrahim, Carter M. Suryadevara, Taylor M. Broome, Gary E. Archer, Annick Desjardins, Robert J. Schmittling, Anastasie Dunn-Pirio, Kristen A. Batich
Publikováno v:
Cancer Research. 78:256-264
Median survival for glioblastoma (GBM) remains Significance: A randomized pilot trial in patients with GBM implicates polyfunctional T-cell responses as a biomarker for effective antitumor immunotherapy. Cancer Res; 78(1); 256–64. ©2017 AACR.
Autor:
James Waisman, Carrie Wang, Diana L. Simons, Xuyang Lu, John H. Yim, Vernon C. Maino, Maria A. Suni, Andrea K. Miyahira, Peter P. Lee, Lei Wang, Frederick M. Dirbas, Andrew Y. Chang
Publikováno v:
Cancer Research. 77:1119-1126
IL6 is a pleiotropic cytokine with both pro- and anti-inflammatory properties, which acts directly on cancer cells to promote their survival and proliferation. Elevated serum IL6 levels negatively correlate with survival of cancer patients, which is
Autor:
Einar K. Kristoffersen, Surendra Kumar, Aminur Mohummad Rahman, Morten Lund-Johansen, Andrea Gras Navarro, Gro Njølstad, Per Øyvind Enger, Stein Atle Lie, Christèle Retière, Martha Chekenya, Vessela N. Kristensen, Elling Ulvestad, Mev Dominguez–Valentin, Benedicte A. Lie
Publikováno v:
Cancer Research. 76:5326-5336
By affecting immunological presentation, the presence of cytomegalovirus in some glioblastomas may impact progression. In this study, we examined a hypothesized role for natural killer (NK) cells in impacting disease progression in this setting. We c
Autor:
Linn Gillberg, Gangning Liang, Johanna Ungerstedt, Andreas Due Ørskov, Peter A. Jones, Hitoshi Ohtani, Wanding Zhou, Eva Hellström-Lindberg, Kirsten Grønbæk, Minmin Liu, Alexandra Søgaard Helbo, Weili Sun
Publikováno v:
Cancer Res
The DNA methyltransferase inhibitors (DNMTi) 5-azacytidine and 5-aza-2-deoxycytidine have been approved for the treatment of different types of hematologic malignancies. However, only about 50% of patients respond to treatment. Therefore, a more comp
Autor:
Monique Hanse, Maurice de Wit, Ya Gao, Walter Taal, Jan Buter, Youri Hoogstrate, Peter A. E. Sillevis Smitt, Martin J. van den Bent, Annemiek M E Walenkamp, Johan M. Kros, Laurens V. Beerepoot, Bronno van der Holt, Hina Naz-Khan, Aafke H. Honkoop, Andrew P. Stubbs, René Böttcher, René M. Vernhout, Peter J. van der Spek, HM Oosterkamp, Lale Erdem-Eraslan, Pim J. French
Publikováno v:
Cancer Research, 76(3), 525-534. AMER ASSOC CANCER RESEARCH
Cancer Research, 76(3), 525-34. American Association for Cancer Research Inc.
Erdem-Eraslan, L, van den Bent, M J, Hoogstrate, Y, Naz-Khan, H, Stubbs, A, van der Spek, P, Böttcher, R, Gao, Y, de Wit, M, Taal, W, Oosterkamp, H M, Walenkamp, A, Beerepoot, L V, Hanse, M C J, Buter, J, Honkoop, A H, van der Holt, B, Vernhout, R M, Sillevis Smitt, P A E, Kros, J M & French, P J 2016, ' Identification of Patients with Recurrent Glioblastoma Who May Benefit from Combined Bevacizumab and CCNU Therapy : A Report from the BELOB Trial ', Cancer Research, vol. 76, no. 3, pp. 525-34 . https://doi.org/10.1158/0008-5472.CAN-15-0776
Cancer Research, 76(3), 525-534. American Association for Cancer Research Inc.
Cancer Research, 76(3), 525-34. American Association for Cancer Research Inc.
Erdem-Eraslan, L, van den Bent, M J, Hoogstrate, Y, Naz-Khan, H, Stubbs, A, van der Spek, P, Böttcher, R, Gao, Y, de Wit, M, Taal, W, Oosterkamp, H M, Walenkamp, A, Beerepoot, L V, Hanse, M C J, Buter, J, Honkoop, A H, van der Holt, B, Vernhout, R M, Sillevis Smitt, P A E, Kros, J M & French, P J 2016, ' Identification of Patients with Recurrent Glioblastoma Who May Benefit from Combined Bevacizumab and CCNU Therapy : A Report from the BELOB Trial ', Cancer Research, vol. 76, no. 3, pp. 525-34 . https://doi.org/10.1158/0008-5472.CAN-15-0776
Cancer Research, 76(3), 525-534. American Association for Cancer Research Inc.
The results from the randomized phase II BELOB trial provided evidence for a potential benefit of bevacizumab (beva), a humanized monoclonal antibody against circulating VEGF-A, when added to CCNU chemotherapy in patients with recurrent glioblastoma
Autor:
Lei Huang, Andrew L. Mellor, Yong Zang, Li Yan, JianYue Jin, Shruti Jolly, Weili Wang, Feng-Ming Spring Kong, Huanmei Wu, Wenhu Pi, Lang Li
Publikováno v:
Cancer research. 78(3)
Host immunity influences the impact of radiotherapy (RT) in cancer, but mechanistic connections remain obscure. In this study, we investigated the relationship of indoleamine 2,3-dioxygenase (IDO) systemic activity on clinical outcomes in RT-treated
Autor:
Kranti A. Mapuskar, Bryan G. Allen, Kyle H. Flippo, Frederick E. Domann, Joshua D. Schoenfeld, Dennis P. Riley, Muhammad Furqan, Stefan Strack, John M. Buatti, Douglas R. Spitz, Prabhat C. Goswami, Varun Monga, Taher Abu Hejleh
Publikováno v:
Cancer research. 77(18)
Elderly cancer patients treated with ionizing radiation (IR) or chemotherapy experience more frequent and greater normal tissue toxicity relative to younger patients. The current study demonstrates that exponentially growing fibroblasts from elderly
Autor:
Makiko Kawaguchi, Hideki Fujita, Tomomitsu Miyagaki, Tomonori Oka, Naomi Takahashi, Hiraku Suga, Makoto Sugaya, Shinichi Sato
Publikováno v:
Cancer research. 76(21)
Thymic stromal lymphopoietin (TSLP) activates dendritic cells to induce Th2-mediated inflammation. Periostin, an extracellular matrix protein produced by fibroblasts, induces chronic inflammation by stimulating TSLP production. Recently, a reinforcin
Autor:
Gustavo Sevlever, Eva Serna, Lucía Canedo, Carolina Perez-Castro, Fiorella Sabrina Belforte, Guillermo Agustín Videla-Richardson, Horacio Martinetto, Miguel A. Riudavets, Joaquín M. Espinosa, Nazarena Eugenia Ferreyra Solari, Mario Rossi
Publikováno v:
Cancer research. 76(18)
KANSL2 is an integral subunit of the nonspecific lethal (NSL) chromatin-modifying complex that contributes to epigenetic programs in embryonic stem cells. In this study, we report a role for KANSL2 in regulation of stemness in glioblastoma (GBM), whi