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Autor:
Anwesha Chaudhury, Nuria Chic, Tetiana Taran, D. Martinez, Nadia Solovieff, Karen Rodriguez-Lorenc, Fara Brasó-Maristany, Aleix Prat, Faye Su, Laia Paré, Olga Martínez, Naveen Babbar
Publikováno v:
Cancer Research. 81:GS1-04
Background: The prognostic and predictive value of the 4 main intrinsic subtypes of breast cancer (ie, luminal A [LumA], luminal B [LumB], human epidermal growth factor receptor 2 enriched [HER2E], and basal-like) in hormone receptor-positive, HER2
Autor:
Helen Piwnica-Worms, Cullen M. Taniguchi, Anirban Maitra, Sonal Gupta, Meifang Yu, Amit Deorukhkar, Marimar de la Cruz Bonilla, Yanqing Huang, Charles V. Kingsley, Laura Baseler, Daniel Lin, Lauren E. Colbert, Eugene J. Koay, Tara N. Fujimoto, Gabriel O. Sawakuchi, Jessica M. Molkentine, Peter K. Cabeceiras, Ramesh C. Tailor
Publikováno v:
Cancer Res
When pancreatic cancer cannot be removed surgically, patients frequently experience morbidity and death from progression of their primary tumor. Radiation therapy (RT) cannot yet substitute for an operation because radiation causes fatal bleeding and
Publikováno v:
Cancer Research. 81:3158-3159
Radiotherapy plays an important role in the management of pancreatic ductal adenocarcinoma (PDAC), especially when patients are not surgical candidates. Radiation-induced tumor death provokes an acute inflammation followed by a late-fibrotic response
Autor:
A-M Larsson, Kristina Aaltonen, Sara Jansson, Lisa Rydén, P-O Bendahl, Sharyn D. Baker, Michael Bergqvist
Publikováno v:
Cancer Research. 78:P3-08
Introduction: Although prognosis and treatment of metastatic breast cancer (MBC) have improved over the last years, there is still an unmet clinical need for more precise prognostic and treatment monitoring tools. Liquid-based markers are preferred s
Autor:
Tessa Cigler, Naomi Kornhauser, Vivek Mittal, Alysia Wiener, Amy D. Willis, Maureen M. Ward, Linda T. Vahdat, JD Warren, Anne Moore, Veronica Fitzpatrick, Anna Rubinchik, S Sahota, M Cobham, D Ko, A De Laurentiis, N Prima, Sarah E. Schneider, Eleni Andreopoulou
Publikováno v:
Cancer Research. 78:P1-10
Background: Metals have emerged as a viable therapeutic target for a new generation of anti-cancer and anti-metastatic agents. Copper, an essential trace element, serves as an important catalytic cofactor in several biological functions and has emerg
Autor:
Tobias Xiao Dong, Rui Xie, Jingyu Xu, Hanxing Wan, Hui Dong, John M. Carethers, Ya-Han Fan, Jilin Wu, Bo Tang, Michael X. Zhu, Yu-Yun Wu, Jingjing Liu, Shi-Ming Yang, Suming Wang, Yu-Feng Xiao
Publikováno v:
Cancer Research. 77:6499-6512
Although dietary calcium intake has long been recommended for disease prevention, the influence of calcium in development of cancer in the upper gastrointestinal tract has not been explored. Here, we assess the roles of calcium and calcium-sensing re
Autor:
Yingjun Zhao, Jiwei Zhang, Zhixiang Hu, Ming Yao, Tao Yu, Hongyu Pan, Xianghuo He, Hechun Lin, Dandan Chu, Mingxia Yan, Jing Li, Shengli Li, Bing Chen, Zhe Li, Xiao Zhang, Lei Liu
Publikováno v:
Cancer Research. 77:5782-5794
Long noncoding RNAs (lncRNA) participate in carcinogenesis and tumor progression in lung cancer. Here, we report the identification of a lncRNA signature associated with metastasis of non–small cell lung cancer (NSCLC). In particular, elevated expr
Autor:
Valentina Labanca, Stefania Orecchioni, Francesco Bertolini, Andrea Manconi, Cristina Rabascio, Francesca Reggiani, Patrizia Mancuso, Giovanna Talarico
Publikováno v:
Cancer Research. 77:5169-5182
A cell population with progenitor-like phenotype (CD45-CD34+) resident in human white adipose tissue (WAT) is known to promote the progression of local and metastatic breast cancer and angiogenesis. However, the molecular mechanisms of the interactio
Publikováno v:
Cancer Research. 77:1395-1407
Hepatocellular carcinoma (HCC) occurs more frequently and aggressively in men than women, but the mechanistic basis of this gender disparity is obscure. Chronic inflammation is a major etiologic factor in HCC, so we investigated the role of cortisol
Autor:
M Oesterholt, C.M.L. van Herpen, E.C. Mommers, Ahmad Awada, Ingrid M.E. Desar, Christian D. Rolfo, Iain R. Macpherson, Emma Dean, J.S. Lim, Udai Banerji, P. Goedings, Norbert P Koper, Philippe Aftimos
Publikováno v:
Cancer Research. 77:P6-12
Background: SYD985 is a HER2-targeting antibody-drug conjugate (ADC) based on trastuzumab and a cleavable linker-duocarmycin (vc-seco-DUBA) payload. Following proteolytic cleavage the synthetic duocarmycin prodrug is activated, binds to the minor gro