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Autor:
Anwesha Chaudhury, Nuria Chic, Tetiana Taran, D. Martinez, Nadia Solovieff, Karen Rodriguez-Lorenc, Fara Brasó-Maristany, Aleix Prat, Faye Su, Laia Paré, Olga Martínez, Naveen Babbar
Publikováno v:
Cancer Research. 81:GS1-04
Background: The prognostic and predictive value of the 4 main intrinsic subtypes of breast cancer (ie, luminal A [LumA], luminal B [LumB], human epidermal growth factor receptor 2 enriched [HER2E], and basal-like) in hormone receptor-positive, HER2
Autor:
Helen Piwnica-Worms, Cullen M. Taniguchi, Anirban Maitra, Sonal Gupta, Meifang Yu, Amit Deorukhkar, Marimar de la Cruz Bonilla, Yanqing Huang, Charles V. Kingsley, Laura Baseler, Daniel Lin, Lauren E. Colbert, Eugene J. Koay, Tara N. Fujimoto, Gabriel O. Sawakuchi, Jessica M. Molkentine, Peter K. Cabeceiras, Ramesh C. Tailor
Publikováno v:
Cancer Res
When pancreatic cancer cannot be removed surgically, patients frequently experience morbidity and death from progression of their primary tumor. Radiation therapy (RT) cannot yet substitute for an operation because radiation causes fatal bleeding and
Autor:
A-M Larsson, Kristina Aaltonen, Sara Jansson, Lisa Rydén, P-O Bendahl, Sharyn D. Baker, Michael Bergqvist
Publikováno v:
Cancer Research. 78:P3-08
Introduction: Although prognosis and treatment of metastatic breast cancer (MBC) have improved over the last years, there is still an unmet clinical need for more precise prognostic and treatment monitoring tools. Liquid-based markers are preferred s
Autor:
Tessa Cigler, Naomi Kornhauser, Vivek Mittal, Alysia Wiener, Amy D. Willis, Maureen M. Ward, Linda T. Vahdat, JD Warren, Anne Moore, Veronica Fitzpatrick, Anna Rubinchik, S Sahota, M Cobham, D Ko, A De Laurentiis, N Prima, Sarah E. Schneider, Eleni Andreopoulou
Publikováno v:
Cancer Research. 78:P1-10
Background: Metals have emerged as a viable therapeutic target for a new generation of anti-cancer and anti-metastatic agents. Copper, an essential trace element, serves as an important catalytic cofactor in several biological functions and has emerg
Autor:
Tobias Xiao Dong, Rui Xie, Jingyu Xu, Hanxing Wan, Hui Dong, John M. Carethers, Ya-Han Fan, Jilin Wu, Bo Tang, Michael X. Zhu, Yu-Yun Wu, Jingjing Liu, Shi-Ming Yang, Suming Wang, Yu-Feng Xiao
Publikováno v:
Cancer Research. 77:6499-6512
Although dietary calcium intake has long been recommended for disease prevention, the influence of calcium in development of cancer in the upper gastrointestinal tract has not been explored. Here, we assess the roles of calcium and calcium-sensing re
Autor:
Yingjun Zhao, Jiwei Zhang, Zhixiang Hu, Ming Yao, Tao Yu, Hongyu Pan, Xianghuo He, Hechun Lin, Dandan Chu, Mingxia Yan, Jing Li, Shengli Li, Bing Chen, Zhe Li, Xiao Zhang, Lei Liu
Publikováno v:
Cancer Research. 77:5782-5794
Long noncoding RNAs (lncRNA) participate in carcinogenesis and tumor progression in lung cancer. Here, we report the identification of a lncRNA signature associated with metastasis of non–small cell lung cancer (NSCLC). In particular, elevated expr
Autor:
Valentina Labanca, Stefania Orecchioni, Francesco Bertolini, Andrea Manconi, Cristina Rabascio, Francesca Reggiani, Patrizia Mancuso, Giovanna Talarico
Publikováno v:
Cancer Research. 77:5169-5182
A cell population with progenitor-like phenotype (CD45-CD34+) resident in human white adipose tissue (WAT) is known to promote the progression of local and metastatic breast cancer and angiogenesis. However, the molecular mechanisms of the interactio
Autor:
Aaron N. Hata, Sophia C. Kamran, Florian J. Fintelmann, Clemens Grassberger, Lecia V. Sequist, Harald Paganetti, Yosef E. Maruvka, Zofia Piotrowska, Henning Willers, Changran Geng, David M. McClatchy
Publikováno v:
Cancer Res
The importance of preexisting versus acquired drug resistance in patients with cancer treated with small-molecule tyrosine kinase inhibitors (TKI) remains controversial. The goal of this study is to provide a general estimate of the size and dynamics
Publikováno v:
Cancer Research. 76:3732-3743
Tumor size is strongly correlated with breast cancer metastasis and patient survival. Increased tumor size contributes to hypoxic and metabolic gradients in the solid tumor and to an aggressive tumor phenotype. Thus, it is important to develop three-
Autor:
Martin Reck, Heimo Mairbäurl, Karin Müller-Decker, Marvin Wäsch, Torsten Goldmann, Ekkehard Vollmer, Reiner Siebert, Swetlana Scheufele, Sofia Depner, Ruth Merkle, Ole Ammerpohl, Magdalena Szczygiel, Sebastian Marwitz, Philippe Lucarelli, Maren Kröger, Christian Kugler, Ursula Klingmüller, Dmytro Dvornikov, Klaus F. Rabe
Publikováno v:
Cancer Research. 76:3785-3801
Non–small cell lung cancer (NSCLC) is characterized by early metastasis and has the highest mortality rate among all solid tumors, with the majority of patients diagnosed at an advanced stage where curative therapeutic options are lacking. In this