Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Hariharan Easwaran"'
Autor:
Na Wang, Ray-Whay Chiu Yen, Hamza Khan, Malcolm V. Brock, Hariharan Easwaran, Stephen B. Baylin, Michelle Vaz
Publikováno v:
Cancer Research. 83:LB046-LB046
One of the most important goals of developing timely detection and effective intervention strategies for lung cancer is to understand the biology and molecular mechanisms involved in early-stage evolution of this disease. Chronic inflammation is a ma
Autor:
Yuba R. Bhandari, Vinod Krishna, Rachael Powers, Sehej Parmar, Sara-Jayne Thursby, Ekta Gupta, Ozlem Kulak, Prashanth Gokare, Joke Reumers, Liesbeth Van Wesenbeeck, Kurtis E. Bachman, Stephen B. Baylin, Hariharan Easwaran
Publikováno v:
Cancer Research. 82:A012-A012
Colorectal cancers (CRCs) form a heterogenous group classified into epigenetic and transcriptional subtypes. The basis for the epigenetic subtypes, exemplified by varying degrees of promoter DNA hypermethylation, and its relation to the transcription
Autor:
Anne Huber, Christine Dijkstra, Yuba Bhandari, Hariharan Easwaran, Stephen Baylin, Matthias Ernst, Moritz Eissmann
Publikováno v:
Cancer Research. 82:A008-A008
Gastric cancer (GC) remains the third leading cause of cancer-related death worldwide. While inflammation is a well-established driver of gastric tumorigenesis, only a small subset of GC patients responds to immunotherapy. One proposed mechanism of i
Autor:
Steve Baylin, Hariharan Easwaran, Vinod Krishna, Kurtis E. Bachman, Sehej Parmar, Yuba R. Bhandari, Rachael Powers
Publikováno v:
Cancer Research. 81:2107-2107
Colorectal cancer (CRC) is classified into distinct subtypes based on genetic, epigenetic and/or transcriptional subtypes. The underlying mechanisms that drive these subtypes are unknown. By integrating whole genome DNA methylation, gene expression,
Publikováno v:
Cancer Research. 80:A36-A36
Background: Tumor initiation and development occur not necessarily by genetic changes alone, but in the context of the epigenome and cell microenvironment. Growing evidence indicate that cancer risk factors, such as aging and inflammation, may primar
Autor:
Xiangqian Kong, Jie Chen, Wenbing Xie, Stephen M. Brown, Yi Cai, Kaichun Wu, Daiming Fan, Yongzhan Nie, Yong Tao, Ray-Whay Chiu Yen, Hariharan Easwaran, Michael J. Topper, Scott B. Rothbart, Limin Xia, Stephen B. Baylin
Publikováno v:
Cancer Research. 79:947-947
Reversing the DNA methylation abnormalities by targeting the maintenance DNA methylation machinery represents a sought-after therapy paradigm in both liquid and solid tumors. UHRF1, a multi-domain protein with both chromatin reader and writer functio
Autor:
Stephen B. Baylin, Subhojit Sen, Leslie Cope, Leander Van Neste, Gayle Jeannette Pageau, Kornel E. Schuebel, Hariharan Easwaran, Jeanne B. Lawrence, Helai P. Mohammad, James G. Herman
Publikováno v:
Cancer Research. 70:8015-8024
Aberrant promoter DNA-hypermethylation and repressive chromatin constitutes a frequent mechanism of gene inactivation in cancer. There is great interest in dissecting the mechanisms underlying this abnormal silencing. Studies have shown changes in th
Autor:
Helai P. Mohammad, Heather M. O'Hagan, Stephen B. Baylin, Joyce E. Ohm, Yi Cai, Hariharan Easwaran, Leander Van Neste, Kelly M. McGarvey
Publikováno v:
Cancer Research. 69:6322-6330
Epigenetic silencing of genes in association with aberrant promoter DNA hypermethylation has emerged as a significant mechanism in the development of human cancers. Such genes are also often targets of the polycomb group repressive complexes in embry
Autor:
D. Neil Watkins, Leander Van Neste, Stephen B. Baylin, Hariharan Easwaran, Mingzhou Guo, Sabine C. Glöckner, James G. Herman, Wei Zhang, Kornel E. Schuebel, Nita Ahuja, David H. Wang, Emi Ota Machida
Publikováno v:
Cancer Research. 68:2764-2772
SRY-box containing gene 17 (Sox17) is a member of the high mobility group (HMG) transcription factor superfamily, which plays critical roles in the regulation of development and stem/precursor cell function, at least partly through repression of Wnt
Autor:
Byunghak Kang, Jean Pierre J. Issa, Julie In, Stephen B. Baylin, Nicholas C. Zachos, David L. Huso, Hariharan Easwaran, Shinji Maegawa
Publikováno v:
Cancer Research. 76:4273-4273
Herein, we report a model for how BRAF mutations, in contrast to KRAS mutations, specifically associate with and induce, in mouse colon organoids without a microenvironment, the phenotype of human sporadic right-sided colon adenocarcinomas (COAD). Th